Dietary polyphenols as potential nutraceuticals in management of diabetes: a review

Journal of Diabetes & Metabolic Disorders

Fereidoun Azizi¹  Parvin Mirmiran³  Zahra Bahadoran² 

[1] Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24 Parvaneh St, Yemen St, Chamran Exp, 19395-4763 Tehran, Iran;Nutrition and Endocrine Research Center, and Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24 Parvaneh St, Yemen St, Chamran Exp, 19395-4763 Tehran, Iran;Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, No 46 Arghavan-e-gharbi St, Farahzadi Blv, Shahrak-e-Ghods, 19395-4741 Tehran, Iran

关键词: Diabetes complications;    Type 2 diabetes;    Lignans;    Stilbenes;    Flavonoids;    Phenolic acids;    Polyphenols;   

Others  :  806841
DOI  :  10.1186/2251-6581-12-43

 received in 2013-04-09, accepted in 2013-08-07,  发布年份 2013

【 摘 要 】

In recent years, there is growing evidence that plant-foods polyphenols, due to their biological properties, may be unique nutraceuticals and supplementary treatments for various aspects of type 2 diabetes mellitus. In this article we have reviewed the potential efficacies of polyphenols, including phenolic acids, flavonoids, stilbenes, lignans and polymeric lignans, on metabolic disorders and complications induced by diabetes. Based on several in vitro, animal models and some human studies, dietary plant polyphenols and polyphenol-rich products modulate carbohydrate and lipid metabolism, attenuate hyperglycemia, dyslipidemia and insulin resistance, improve adipose tissue metabolism, and alleviate oxidative stress and stress-sensitive signaling pathways and inflammatory processes. Polyphenolic compounds can also prevent the development of long-term diabetes complications including cardiovascular disease, neuropathy, nephropathy and retinopathy. Further investigations as human clinical studies are needed to obtain the optimum dose and duration of supplementation with polyphenolic compounds in diabetic patients.

【 授权许可】

   
2013 Bahadoran et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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