Does continuous endurance exercise in water elicit a higher release of ANP and BNP and a higher plasma concentration of FFAs in pre-obese and obese men than high intensity intermittent endurance exercise? – Study protocol for a randomized controlled trial

Trials

Thomas Rosemann³  Joeri Gredig¹  Matthias Fenzl¹  Beat Knechtle²  Klaus Karner-Rezek⁴ 

[1] Swiss Olympic Medical Center, Medizinisches Zentrum, Bad Ragaz, Switzerland;Gesundheitszentrum St. Gallen, St. Gallen, Switzerland;Institute of General Practice and for Health Services Research, University of Zurich, Zurich, Switzerland;Private University of the Principality of Liechtenstein, Triesen, Principality of Liechtenstein

关键词: Water immersion;    Exercise intensity;    EPOC;    BNP;    ANP;    Obesity;   

Others  :  1092913
DOI  :  10.1186/1745-6215-14-328

 received in 2013-03-16, accepted in 2013-10-01,  发布年份 2013

【 摘 要 】

Background

Atrial natriuretic peptides (ANP) and Brain natriuretic peptides (BNP) stimulate fat cell plasma membrane receptors. They are potent lipolytic agents on isolated fat cells from subcutaneous adipose tissue. The physiological effects of continuous endurance exercise on ANP release and plasma free fatty acids (FFA) concentrations have been well described. The enhancement of fat metabolism using high intensity intermittent exercise protocols has been assessed in more recent investigations. The combined effects of endurance exercise and water immersion on ANP and FFA plasma concentration and the magnitude of excess post-exercise oxygen consumption (EPOC) might be further enhanced by choosing the most effective exercise protocol. Exercise modalities may play a significant role in the future prevention and treatment of obesity.

Methods/design

The two testing trials will be performed according to a randomized and cross-over design. Twenty healthy sedentary pre-obese and obese class-1 men will be scrutinized with regard to their metabolic responses to continuous exercise in water and to high intensity endurance exercise in water. Both trials will be matched for energy expenditure. After preliminary testing, the tests will be conducted as repeated measurements. The two different exercise protocols will be compared. The aims of the study are to investigate (1) whether continuous endurance exercise or high intensity intermittent endurance exercise in water elicits both a higher release of ANP and BNP and a higher plasma concentration of glycerol and (2) to determine whether continuous endurance exercise in water or a high intensity intermittent endurance exercise in water would lead to a more pronounced short term (two hours) EPOC effect.

Discussion

If our hypothesis would be confirmed, the most effective exercise protocol based on the combined effects of high intensity endurance exercise and water immersion on ANP and BNP release and glycerol plasma concentrations can be identified. Moreover, the magnitude of the EPOC effect can be augmented. Our study would provide a major contribution for creating optimized exercise modalities in the prevention and treatment of obesity.

Trial registration

Current controlled trials, ISRCTN95488515

【 授权许可】

   
2013 Karner-Rezek et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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