Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis

Cancer Cell International

Junqiang Chen³  Zhiping Chen²  Xue Qin¹  Shan Li¹  Yu Lu¹  Qiliu Peng¹  Xianjun Lao¹ 

[1] Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China;Department of Occupational Health and Environmental Health, School of Public Health at Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China;Department of Gastrointestinal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China

关键词: Meta-analysis;    Gene-gene interaction;    Glutathione S-transferase M1;    Genetic polymorphism;    Gastric cancer;   

Others  :  1121620
DOI  :  10.1186/s12935-014-0127-3

 received in 2014-10-26, accepted in 2014-11-10,  发布年份 2014

【 摘 要 】

Background

The null genotype of GSTM1 have been implicated in gastric cancer risk, but numerous individual studies showed mixed, or even conflicting results. Thus, a meta-analysis was performed.

Results

We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library. It was found that the null genotype of GSTM1 was associated with an increased gastric cancer risk (OR = 1.207, 95% CI: 1.106-1.317, P < 0.001), under the random-effects model (I² : 49.9%, P_Q <0.001). From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas null result was found in the subgroups of alcohol drinking. We also undertook gene-gene interaction analysis between GSTM1 and GSTT1 genes for gastric cancer risk, and the results indicated that the dual null genotypes of GSTM1 and GSTT1 might elevate the risk of gastric cancer (OR = 1.505, 95% CI: 1.165-1.944, P = 002).

Conclusions

This meta-analysis suggests that the null genotype of GSTM1 may be a important genetic risk factor for gastric cancer development.

【 授权许可】

   
2014 Lao et al.; BioMed Central Ltd.

【 图 表 】

Figure 1.

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Figure 3.

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