Health-related quality of life and survival in Chinese patients with chronic liver disease

Health and Quality of Life Outcomes

Jian Yu Hao¹  Zhan Min Shang¹  Guang Li¹  Ru Gao¹  Feng Gao¹ 

[1] Digestive Department, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gong Ren Ti Yu Chang Nan Road, Chao Yang District, Beijing 100020, China

关键词: Survival;    SF-36;    Chronic liver disease;    Health-related quality of life;   

Others  :  823390
DOI  :  10.1186/1477-7525-11-131

 received in 2013-03-23, accepted in 2013-07-30,  发布年份 2013

【 摘 要 】

Background

To investigate the relationship between health-related quality of life (HRQOL) and survival in Chinese patients with chronic liver disease (CLD).

Methods

HRQOL was measured with the Chinese version of Short Form 36 (SF-36). SF-36 scores, demographic and clinical data were collected at baseline and after 18 months follow-up. Kaplan-Meier and Cox Proportional Hazard Regression survival analyses were used for interpretation of data. Surviving patients were censored in the analyses.

Results

A total of 415 Chinese patients with CLD and 86 healthy controls were enrolled. During the follow-up period 50 patients died. SF-36 scores in healthy controls and surviving patients were higher compared with those in deceased patients. Scores of physical component summary (PCS) in healthy controls, surviving and deceased patients were 54.1 ± 5.2, 48.9 ± 7.7 and 33.5 ± 8.2 respectively (p < 0.001). Scores of mental component summary (MCS) in healthy controls, surviving and deceased patients were 56.6 ± 8.2, 53.0 ± 5.6 and 37.1 ± 12.1 (p < 0.001) respectively. Survival was significantly associated with PCS and MCS scores, and the presence of ascites.

Conclusions

HRQOL was associated with survival in patients with CLD. PCS and MCS scores were predictors of survival.

【 授权许可】

   
2013 Gao et al.; licensee BioMed Central Ltd.

【 图 表 】

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