Efficacy of pre-exercise low-level laser therapy on isokinetic muscle performance in individuals with type 2 diabetes mellitus: study protocol for a randomized controlled trial

Trials

Paulo de Tarso Camillo de Carvalho³  Adriane Aver Vanin³  Fernanda Colella Antonialli³  Marcelo Frigero²  Adriano Rodrigues de Oliveira²  Almir Vieira Dibai-Filho¹  Tabajara de Oliveira Gonzalez²  Fabiano Politti³  Yasmin El-Hage²  Daniela Aparecida Biasotto-Gonzalez³  Ernesto Cesar Pinto Leal-Junior³  Cid André Fidelis de Paula Gomes² 

[1] Postgraduate Program in Rehabilitation and Functional Performance, University of São Paulo, Ribeirão Preto, v. Bandeirantes, 3900 - Curso de Fisioterapia/Casa 2, Monte Alegre, São Paulo 14049-900, Brazil;Department of Physical Therapy, Universidade Nove de Julho (UNINOVE), Av. Dr. Adolfo Pinto, 109. Água Branca, São Paulo, SP 05001-100, Brazil;Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), Av. Dr. Adolfo Pinto, 109. Água Branca, São Paulo, SP 05001-100, Brazil

关键词: Physical Therapy Modalities;    Quadriceps Muscle;    Skeletal;    Muscle;    Low-Level Laser Therapy;    Diabetes Mellitus;   

Others  :  806991
DOI  :  10.1186/1745-6215-15-116

 received in 2013-10-27, accepted in 2014-03-20,  发布年份 2014

【 摘 要 】

Background

Type 2 diabetes, also known non-insulin-dependent diabetes, is the most prevalent type of the disease and involves defects in the secretion and action of insulin. The aim of the proposed study is to evaluate the efficacy of pre-exercise low-level laser therapy (LLLT) on muscle performance of the quadriceps femoris in individuals with type 2 diabetes.

Methods/Design

A double-blind, randomized, controlled clinical trial will be carried out in two treatment phases. In the first phase, quadriceps muscle performance will be evaluated using an isokinetic dynamometer and the levels of creatine kinase and lactate dehydrogenase (biochemical markers of muscle damage) will be determined. The participants will then be allocated to four LLLT groups through a randomization process using opaque envelopes: Group A (4 Joules), Group B (6 Joules), Group C (8 Joules) and Group D (0 Joules; placebo). Following the administration of LLLT, the participants will be submitted to an isokinetic eccentric muscle fatigue protocol involving the quadriceps muscle bilaterally. Muscle performance and biochemical markers of muscle damage will be evaluated again immediately after as well as 24 and 48 hours after the experimental protocol. One week after the last evaluation the second phase will begin, during which Groups A, B and C will receive the LLLT protocol that achieved the best muscle performance in phase 1 for a period of 4 weeks. At the end of this period, muscle performance will be evaluated again. The protocol for this study is registered with the World Health Organization under Universal Trial Number U1111-1146-7109.

Discussion

The purpose of this randomized clinical trial is to evaluate the efficacy of pre-exercise LLLT on the performance of the quadriceps muscle (peak torque, total muscle work, maximum power and fatigue index – normalized by body mass) in individuals with DM-2. The study will support the practice of evidence-based to the use of LLLT in improving muscle performance in Individuals with DM-2. Data will be published after the study is completed.

【 授权许可】

   
2014 Gomes et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Castaneda F, Layne JE, Castaneda C: Skeletal muscle sodium glucose co-transporters in older adults with type 2 diabetes undergoing resistance training. American Diabetes Association. Standards of medical care in diabetes. Int J Med Sci 2006, 3:84-91.
• [2]Bonadonna RC, Del Prato S, Bonora E, Saccomani MP, Gulli G, Natail A, Frascerra S, Pecori N, Ferrannini E, Bier D, Cobelli C, DeFronzo RA: Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM. Diabetes 1996, 45:915-925.
• [3]American Diabetes Association: Standards of medical care in diabetes. Diabetes Care 2005, 28(suppl 1):S4-S36.
• [4]Wallberg-Henriksson H, Rincon J, Zierath JR: Exercise in the management of non-insulin-dependent diabetes mellitus. Sports Med 1998, 25:25-35.
• [5]Dunstan DW, Daly RM, Owen N, Jolley D, Courten M, Shaw J, Zimmet P: High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care 2002, 25:1729-1736.
• [6]Camargo JL, Gross JL: Glycohemoglobin (GHb): clinical and analytical aspects. Arq Bras Endocrinol Metabol 2004, 48:451-463.
• [7]Park SW, Goodpaster BH, Strotmeyer ES, de Rekeneire N, Harris TB, Schwartz AV, Tylavsky FA, Newman AB: Decreased muscle strength and quality in older adults with type 2 diabetes: the health, aging, and body composition study. Diabetes 2006, 55:1813-1818.
• [8]Cetinus E, Buyukbese MA, Uzel M, Ekerbicer H, Karaoguz A: Hand grip strength in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2005, 70:278-286.
• [9]Fang ZY, Sharman J, Prins JB, Marwick TH: Determinants of exercise capacity in patients with type 2 diabetes. Diabetes Care 2005, 28:1643-1648.
• [10]Katoh J, Hara Y, Kurusu M, Miyaji J, Narutaki K: Cardiorespiratory function as assessed by exercise testing in patients with non-insulin dependent diabetes mellitus. J Int Med Res 1996, 24:209-213.
• [11]Church TS, Cheng YJ, Earnest CP, Barlow CE, Gibbons LW, Priest EL, Blair SN: Exercise capacity and body composition as predictors of mortality among men with diabetes. Diabetes Care 2004, 27:83-88.
• [12]Watanabe K, Miyamoto T, Tanaka Y, Fukuda K, Moritani T: Type 2 diabetes mellitus patients manifest characteristic spatial EMG potential distribution pattern during sustained isometric contraction. Diabetes Res Clin Pract 2012, 97:468-473.
• [13]Chow RT, Johnson MI, Lopes-Martins RA, Bjordal JM: Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomized placebo or active-treatment controlled trials. Lancet 2009, 374:1897-1908.
• [14]Lopes-Martins RA, Marcos RL, Leonardo PS, Prianti AC Jr, Muscara MN, Aimbire F, Frigo L, Iversen VV, Bjordal JM: Effect of low-level laser (Ga-Al-As 655 nm) on skeletal muscle fatigue induced by electrical stimulation in rats. J Appl Physiol 2006, 101:283-288.
• [15]Leal Junior EC, Lopes-Martins RA, de Almeida P, Ramos L, Iversen VV, Bjordal JM: Effect of low-level laser therapy (GaAs 904 nm) in skeletal muscle fatigue and biochemical markers of muscle damage in rats. Eur J Appl Physiol 2010, 108:1083-1088.
• [16]Sussai DA, Carvalho Pde T, Dourado DM, Belchior AC, dos Reis FA, Pereira DM: Low-level laser therapy attenuates creatine kinase levels and apoptosis during forced swimming in rats. Lasers Med Sci 2010, 25:115-120.
• [17]Liu XG, Zhou YJ, Liu TC, Yuan JQ: Effects of low-level laser irradiation on rat skeletal muscle injury after eccentric exercise. Photomed Laser Surg 2009, 27:863-869.
• [18]Ferraresi C, de Brito OT, de Oliveira ZL, de Menezes Reiff RB, Baldissera V, de Andrade Perez SE, Junior EM, Parizotto NA: Effects of low level laser therapy (808 nm) on physical strength training in humans. Lasers Med Sci 2011, 26:349-358.
• [19]Baroni BM, Leal Junior EC, De Marchi T, Lopes AL, Salvador M, Vaz MA: Low level laser therapy before eccentric exercise reduces muscle damage markers in humans. Eur J Appl Physiol 2010, 110:789-796.
• [20]Paolillo FR, Corazza AV, Borghi-Silva A, Parizotto NA, Kurachi C, Bagnato VS: Infrared LED irradiation applied during high-intensity treadmill training improves maximal exercise tolerance in postmenopausal women: a 6-month longitudinal study. Lasers Med Sci 2012, 28:415-422.
• [21]Vieira WH, Ferraresi C, Perez SE, Baldissera V, Parizotto NA: Effects of low-level laser therapy (808 nm) on isokinetic muscle performance of young women submitted to endurance training: a randomized controlled clinical trial. Lasers Med Sci 2012, 27:497-504.
• [22]Xu X, Zhao X, Liu TC, Pan H: Low-intensity laser irradiation improves the mitochondrial dysfunction of C2C12 induced by electrical stimulation. Photomed Laser Surg 2008, 26:197-202.
• [23]Manteifel V, Bakeeva L, Karu T: Ultrastructural changes in chondriome of human lymphocytes after irradiation with He-Ne laser: appearance of giant mitochondria. J Photochem Photobiol B 1997, 38:25-30.
• [24]Binkley JM, Stratford PW, Lott SA, Riddle DL: The Lower Extremity Functional Scale (LEFS): scale development, measurement properties, and clinical application. North American Orthopaedic Rehabilitation Research Network. Phys Ther 1999, 79:371-383.
• [25]Metsavaht L, Leporace G, Riberto M, Sposito MM, Del Castillo LN, Oliveira LP, Batista LA: Translation and cross-cultural adaptation of the lower extremity functional scale into a Brazilian Portuguese version and validation on patients with knee injuries. J Orthop Sports Phys Ther 2012, 42:932-939.
• [26]Correr CJ, Pontarolo R, Melchiors AC, Rossignoli P, Fernández-Llimós F, Radominski RB: Translation to Portuguese and validation of the Diabetes Quality of life measure (DQOL-Brazil). Arq Bras Endocrinol Metabol 2008, 52:515-522.
• [27]Welch G, Weinger K, Anderson B, Polonsky WH: Responsiveness of the problem areas in diabetes (PAID) questionnaire. Diabet Med 2003, 20:69-72.
• [28]Gross CC, Scain SF, Scheffel R, Gross JL, Hutz CS: Brazilian version of the Problem Areas in Diabetes Scale (B-PAID): validation and identification of individuals at high risk for emotional distress. Diabetes Res Clin Pract 2007, 6:455-459.
• [29]Huang MC, Hung CH: Quality of life: its predictors for middle-aged and elderly patients with type 2 diabetes mellitus. J Nurs Res 2007, 15:193-201.
• [30]Cruz LN, Polanczyk CA, Camey SA, Hoffmann JF, Fleck MP: Quality of life in Brazil: normative values for the WHOQOL-BREF in a Southern general population sample. Qual Life Res 2011, 20:1123-1129.
• [31]Fleck MPA, Leal OF, Louzada S, Xavier M, Chachamovich E, Vieira G, Santos L, Pinzon V: Development of the Portuguese version of the OMS evaluation instrument of quality of life. Rev Bras Psiquiatr 1999, 21:19-28.
• [32]Horn KK, Jennings S, Richardson G, Vliet DV, Hefford C, Abbott JH: The patient-specific functional scale: psychometrics, clinimetrics, and application as a clinical outcome measure. J Orthop Sports Phys Ther 2012, 42:30-42.
• [33]Bautmans I, Njemini R, Predom H, Lemper JC, Mets T: Muscle endurance in elderly nursing home residents is related to fatigue perception, mobility, and circulating tumor necrosis factor-alpha, interleukin-6, and heat shock protein 70. J Am Geriatr Soc 2008, 56:389-396.
• [34]Bautmans I, Gorus E, Njemini R, Mets T: Handgrip performance in relation to self-perceived fatigue, physical functioning and circulating IL-6 in elderly persons without inflammation. BMC Geriatr 2007, 7:5. BioMed Central Full Text
• [35]Yoshioka S, Nagano A, Hay DC, Fukashiro S: Biomechanical analysis of the relation between movement time and joint moment development during a sit-to-stand task. Biomed Eng 2009, 8:27.
• [36]Vaz MM, Costa GC, Reis JG, Junior WM, de Paula FJA, Abreu DC: Postural control and functional strength in patientes with type 2 diabetes mellitus with and without peripheral neuropathy. Arch Phys Med Rehabil 2013, 94:2465-2470.
• [37]Karuka AH, Silva JAMG, Navega MT: Analysis of agreement of assessment tools of body balance in the elderly. Rev Bras Fisioter 2011, 15:460-466.
• [38]Bischoff HA, Stähelin HB, Monsch AU, Iversen MD, Weyh A, von Dechend M, Akos R, Conzelmann M, Dick W, Theiler R: Identifying a cut-off point for normal mobility: a comparison of the timed ‘up and go’ test in community-dwelling and institutionalized elderly women. Age Ageing 2003, 32:315-320.
• [39]Maranesi E, Ghetti G, Rabini RA, Fioretti S: Functional reach test: movement strategies in diabetic subjects. Gait Posture 2014, 39:501-505.
• [40]Duncan PW, Weiner DK, Chandler J, Studenski S: Functional reach: a new clinical measure of balance. J Gerontol 1990, 45:192-197.
• [41]Brancaccio P, Limongelli FM, Maffuli N: Monitoring of serum enzymes in sport. Br J Sports Med 2006, 40:96-97.
• [42]Gojanovic B, Feihl L, Gremion G, Waeber B: Whole body vibration training elevates creatine kinase levels in sendentary subjects. Swiss Med Wkly 2011, 141:w1322.
• [43]Pires AC, Dias FG, Robles FC, Neto DL: Analysis of fingerstick capillary glycemia versus alternative site – results and patients preferences. Arq Bras Endocrinol Metabol 2009, 53:344-347.
• [44]Pincivero DM, Lephart SM, Karunakara RA: Reliability and precision of isokinetic strength and muscular endurance for the quadriceps and hamstrings. Int J Sports Med 1997, 18:113-117.
• [45]Quittan M, Wiesinger GF, Crevenna R, Nuhr MJ, Sochor A, Pacher R, Fialka-Moser V: Isokinetic strength testing in patients with chronic heart failure: a reliability study. Int J Sports Med 2001, 22:40-44.
• [46]Wessel J: Isometric strength measurements of knee extensors in women with osteoarthritis of the knee. J Rheumatol 1996, 23:328-331.
• [47]May LA, Burnham RS, Steadward RD: Assessment of isokinetic and hand-held dynamometer measures of shoulder rotator strength among individuals with spinal cord injury. Arch Phys Med Rehabil 1997, 78:251-255.
• [48]Burnett CN, Betts EF, King WM: Isokinetic profile of wrist and forearm strength in elite female junior tennis players. Br J Sports Med 2006, 40:411-414.
• [49]Amorim AM, Leme LE: Isokinetic dynamometry in elderly women undergoing total knee arthroplasty: a comparative study. Clinics 2006, 61:215-222.
• [50]Davies GJ: A Compendium of Isokinetics in Clinical Usage and Rehabilitation Techniques. 4th edition. Onalaxka, Wisconsin: S & S Publishers; 1992.
• [51]Pincivero DM, Gandaio CM, Ito Y: Gender-specific knee extensor torque, flexor torque, and muscle fatigue responses during maximal effort contractions. Eur J Appl Physiol 2003, 89:134-141.
• [52]Powers SK, Howley ET: Exercise Physiology: Theory and Application to Fitness and Performance. 5th edition. New York: McGraw-Hill; 2004:216-217.