Decreased pre-surgical CD34+/CD144+ cell number in patients undergoing coronary artery bypass grafting compared to coronary artery disease-free valvular patients

Journal of Cardiothoracic Surgery

Teresa Tejerina⁴  Christian Weber²  Enrique Rodríguez⁶  Jose Martinez-Gonzalez¹  Manuel Carnero⁶  Fernando Reguillo⁶  Antonio Gordillo-Moscoso⁵  Mihail Hristov²  Marta Ramajo⁴  Jorge Navarro-Dorado⁴  Álvaro González-Rocafort⁶  Santiago Redondo³ 

[1] Cardiovascular Research Center (CSIC-ICCC), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Klinikum der LMU, Munich, Germany;Service of Hematology, Hospital Nuestra Señora de Sonsoles, Ávila, Spain;Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain;Department of Clinical Research, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico;Service of Cardiac Surgery, Hospital Clinico San Carlos, Madrid, Spain

关键词: coronary artery disease;    endothelial progenitor cells;    cardiac surgery;   

Others  :  1153542
DOI  :  10.1186/1749-8090-7-2

 received in 2011-09-14, accepted in 2012-01-03,  发布年份 2012

【 摘 要 】

Background

Cardiovascular disease has been linked to endothelial progenitor cell (EPC) depletion and functional impairment in atherosclerosis and aortic stenosis. EPCs may play a pivotal role in vascular grafting. However, the EPC depletion in coronary artery bypass grafting (CABG) patients has not been compared to coronary artery disease-free valvular replacement patients with aortic stenosis.

Methods

We aimed to assess the basal number of CD34⁺/KDR⁺ and CD34⁺/CD144⁺ cells in CABG patients, compared to aortic stenosis valvular replacement patients. 100 patients (51 CABG and 49 valvular surgery ones) were included in the present study. All CABG or valvular patients had angiographic demonstration of the presence or the absence of coronary artery disease, respectively. Numbers of CD34⁺/KDR⁺ and CD34⁺/CD144⁺ were assessed by flow cytometry of pre-surgical blood samples.

Results

We found a lower number of CD34⁺/CD144⁺ cells in CABG patients compared to valvular patients (0.21 ± 0.03% vs. 0.47 ± 0.08%), and this difference remained statistically significant after the P was adjusted for multiple comparisons (P = 0.01428). Both groups had more EPCs than healthy controls.

Conclusions

Pre-surgical CD34⁺/CD144⁺ numbers are decreased in CABG patients, compared to valvular patients with absence of coronary disease.

【 授权许可】

   
2012 Redondo et al; licensee BioMed Central Ltd.

【 图 表 】

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