Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis

Cell & Bioscience

Kai Ge¹  Ji-Eun Lee¹ 

[1]Adipocyte Biology and Gene Regulation Section, Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA

关键词: Chromatin remodeling;    Histone methylation;    Histone acetylation;    Epigenetic regulation;    Enhancer;    Transcriptional regulation;    Adipogenesis;    PPARγ;   

Others  :  790529
DOI  :  10.1186/2045-3701-4-29

 received in 2014-04-08, accepted in 2014-05-16,  发布年份 2014

【 摘 要 】

The nuclear receptor PPARγ is a master regulator of adipogenesis. PPARγ is highly expressed in adipose tissues and its expression is markedly induced during adipogenesis. In this review, we describe the current knowledge, as well as future directions, on transcriptional and epigenetic regulation of PPARγ expression during adipogenesis. Investigating the molecular mechanisms that control PPARγ expression during adipogenesis is critical for understanding the development of white and brown adipose tissues, as well as pathological conditions such as obesity and diabetes. The robust induction of PPARγ expression during adipogenesis also serves as an excellent model system for studying transcriptional and epigenetic regulation of cell-type-specific gene expression.

【 授权许可】

   
2014 Lee and Ge; licensee BioMed Central Ltd.

【 图 表 】

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