Reduction of intraoperative air leaks with Progel in pulmonary resection: a comprehensive review

Journal of Cardiothoracic Surgery

Clark Fuller¹ 

[1] Assistant Professor of Surgery, Surgical Director, Esophageal Center, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA

关键词: Surgical equipment;    Surgery;    Perioperative care;    Outcomes;    Lung;   

Others  :  825858
DOI  :  10.1186/1749-8090-8-90

 received in 2012-03-19, accepted in 2012-11-02,  发布年份 2013

【 摘 要 】

Intraoperative alveolar air leaks (IOALs) occur in 75% of patients during pulmonary resection. Despite routine use of sutures and stapling devices, they remain a significant problem in the daily practice of thoracic surgery. Air leaks that persist beyond postoperative day 5 often result in increased costs and complications. Several large meta-analyses have determined that sealants as a class reduce postoperative air leak duration and time to chest drain removal, but these results did not necessarily correlate with a reduction in length of postoperative hospital stay. These analyses grouped surgical sealants together of necessity, but differences in efficacy may exist due to the differing product characteristics, study protocols, surgical procedures, and study endpoints. Progel, currently the only pleural surgical sealant FDA-approved for use in lung resection, has demonstrated efficacy and safety in two controlled clinical studies and superiority over standard air leak closure methods in reducing IOALs and length of hospital stay. This paper will review these findings and report on real-world experience with this recently approved pleural sealant.

【 授权许可】

   
2013 Fuller; licensee BioMed Central Ltd.

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