A clustering analysis of lipoprotein diameters in the metabolic syndrome

Lipids in Health and Disease

Donna K Arnett⁶  Jose M Ordovas⁵  Paul N Hopkins¹  Michael Y Tsai⁸  Hemant K Tiwari²  Ingrid B Borecki⁴  Edmond K Kabagambe⁶  W Timothy Garvey³  Stephen Glasser⁷  Alexis C Frazier-Wood² 

[1] Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA;Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, School of Public Health, AL, USA;Birmingham VA Medical Center, Birmingham, AL, USA;Division of Statistical Genomics, Department of Genetics, Washington University, School of Medicine, 4444 Forest Park Boulevard-Box 8506, St. Louis, MO, USA;JM-USDA-HNRCA, Tufts University, Boston, MA, USA;Nutrition Obesity Research Center, University of Alabama at Birmingham, School of Public Health, AL, USA;Department of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, AL, USA;Department of Laboratory Medicine and Pathology, University of Minnesota, MN

关键词: fasting glucose;    hypertriglyceridemia;    hypertension;    waist circumference;    GOLDN;    latent class analysis;    Metabolic Syndrome;    nuclear resonance spectroscopy;    insulin resistance;    lipoprotein particle diameter;   

Others  :  1212356
DOI  :  10.1186/1476-511X-10-237

 received in 2011-10-28, accepted in 2011-12-19,  发布年份 2011

【 摘 要 】

Background

The presence of smaller low-density lipoproteins (LDL) has been associated with atherosclerosis risk, and the insulin resistance (IR) underlying the metabolic syndrome (MetS). In addition, some research has supported the association of very low-, low- and high-density lipoprotein (VLDL HDL) particle diameters with components of the metabolic syndrome (MetS), although this has been the focus of less research. We aimed to explore the relationship of VLDL, LDL and HDL diameters to MetS and its features, and by clustering individuals by their diameters of VLDL, LDL and HDL particles, to capture information across all three fractions of lipoprotein into a unified phenotype.

Methods

We used nuclear magnetic resonance spectroscopy measurements on fasting plasma samples from a general population sample of 1,036 adults (mean ± SD, 48.8 ± 16.2 y of age). Using latent class analysis, the sample was grouped by the diameter of their fasting lipoproteins, and mixed effects models tested whether the distribution of MetS components varied across the groups.

Results

Eight discrete groups were identified. Two groups (N = 251) were enriched with individuals meeting criteria for the MetS, and were characterized by the smallest LDL/HDL diameters. One of those two groups, one was additionally distinguished by large VLDL, and had significantly higher blood pressure, fasting glucose, triglycerides, and waist circumference (WC; P < .001). However, large VLDL, in the absence of small LDL and HDL particles, did not associate with MetS features. These associations held after additionally controlling for VLDL, LDL and HDL particle concentrations.

Conclusions

While small LDL diameters remain associated with IR and the MetS, the occurrence of these in conjunction with a shift to overall larger VLDL diameter may identify those with the highest fasting glucose, TG and WC within the MetS. If replicated, the association of this phenotype with more severe IR-features indicated that it may contribute to identifying of those most at risk for incident type II diabetes and cardiometabolic disease.

【 授权许可】

   
2011 Frazier-Wood et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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