Sternal intraosseous schwannoma mimicking breast cancer metastasis

Journal of Cardiothoracic Surgery

Kimihiro Shimizu¹  Takashi Ibe¹  Natsuko Kawatani¹  Mitsuhiro Kamiyoshihara¹  Hitoshi Igai¹ 

[1] Department of General Thoracic Surgery, Maebashi Red Cross Hospital, 3-21-36 Asahi-cho, 371-0014, Maebashi, Gunma, Japan

关键词: Intraosseous schwannoma;    Sternum;   

Others  :  823192
DOI  :  10.1186/1749-8090-9-116

 received in 2014-04-22, accepted in 2014-06-23,  发布年份 2014

【 摘 要 】

The preoperative diagnosis of intraosseous schwannoma is challenging because of its rarity. We report a resected case of sternal intraosseous schwannnoma mimicking late recurrence of breast cancer.

A 60-year-old Japanese woman with a history of breast cancer was diagnosed as having a sternal tumor by chest computed tomography (CT) demonstrating a round, well-defined, low-density nodule measuring 3.3 × 2.8 cm, which was located almost at the center of the sternum and associated with bone lysis and erosion. [¹⁸ F]Fluorodeoxyglucose positron emission tomography (FDG-PET)/CT demonstrated FDG accumulation in the tumor, suggesting malignancy. Therefore, late isolated recurrence of breast cancer was suspected. Surgical resection was performed for both confirmation of the diagnosis and treatment.

Pathological examination revealed that the tumor was composed predominantly of spindle-shaped cells arranged in a typical palisading pattern, being compatible with schwannoma. Although the periosteum was intact, the tumor was found to have destroyed the cortex of the sternum and proceeded forward to the bone marrow. Additionally, immunohistochemical staining revealed that the lesion was diffusely and strongly positive for S-100 protein. Thus metastasis from breast cancer was ruled out on the basis of the features revealed by microscopy.

【 授权许可】

   
2014 Igai et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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