Early bioprosthetic valve calcification with alfacalcidol supplementation

Journal of Cardiothoracic Surgery

Jun Amano¹  Daisuke Fukui¹  Kazunori Komatsu¹  Noburou Ohashi¹  Yuko Wada¹  Takamitsu Terasaki¹  Tamaki Takano¹ 

[1] Department of Cardiovascular Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan

关键词: Bioprosthesis;    Heart valve;    Calcification;    Replacement;    Aortic valve;    Biomaterials;    Prosthesis;   

Others  :  829473
DOI  :  10.1186/1749-8090-8-11

 received in 2012-05-01, accepted in 2013-01-14,  发布年份 2013

【 摘 要 】

We report a case of early bioprosthetic valve calcification in a 76 year-old woman who had received supplementation with alfacalcidol, an analogue of vitamin D, for 3 years after her initial valve replacement. She underwent aortic valve replacement at the age of 71 and subsequently complained of shortness of breath. Ultrasonic cardiography revealed severe aortic stenosis and we performed a second aortic valve replacement with a bioprosthesis. Histopathologic and x-ray examination showed calcification on the explanted valve. She had not presented with any known risk for early bioprosthetic calcification, suggesting that vitamin D supplementation may accelerate calcification of bioprosthetic valves.

【 授权许可】

   
2013 Takano et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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