Molecular identification of Mycobacterium avium subspecies paratuberculosis in oral biopsies of Crohn’s disease patients

Gut Pathogens

Stefania Zanetti²  Pietrina Lugliè¹  Alessandra Bua²  Sara Cannas²  Aurea Lumbau¹  Antonio M Scanu³  Paola Molicotti² 

[1] Dipartimento di Scienze Chirurgiche, Microchirurgiche e Mediche. Università degli Studi di Sassari, Sassari, Italy;Dipartimento di Scienze Biomediche – Microbiologia Sperimentale e Clinica, Università degli Studi di Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy;Dipartimento di Medicina Clinica Sperimentale ed Oncologica – Sezione Clinica Chirurgica, Università degli Studi di Sassari, Sassari, Italy

关键词: PCR IS900;    Oral granulomatous lesions;    Oral lesion Crohn;    MAP;   

Others  :  821418
DOI  :  10.1186/1757-4749-5-18

 received in 2013-03-18, accepted in 2013-06-04,  发布年份 2013

【 摘 要 】

Oral lesions may be found in patients with Crohn’s disease (CD), in a percentage up to 20%. The aim of this study was to investigate a possible relationship between Mycobacterium avium subsp. paratuberculosis (MAP) and oral lesions in CD patients. 23 oral biopsies were examined performing IS900 Nested PCR; 9 of them were positive: 8 from CD patients and 1 from a control. Our purpose is to go on with this study, amplifying the number of subjects examined and testing subjects with oral lesions related to diseases other than CD to verify the specific association between MAP and oral lesions in CD patients.

【 授权许可】

   
2013 Molicotti et al.; licensee BioMed Central Ltd.

【 图 表 】

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