The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies

Cilia

Philippe Bastin⁵  Marius Ueffing¹  Peter Swoboda^1,10  Ronald Roepman⁹  Lotte B Pedersen⁴  Hannah M Mitchison⁷  Sigolène M Meilhac²  Christine Laclef³  Linda Kohl^1,13  Tess Harris⁸  Rachel H Giles^1,12  Bénédicte Durand⁶  Alexandre Benmerah^1,11 

[1] Research Unit of Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85758, Germany;CNRS URA2578, 25 rue du docteur Roux, Paris, 75015, France;INSERM, ERL1156, 9 Quai Saint Bernard, Paris, F-75005, France;Department of Biology, University of Copenhagen, Universitetsparken 13, Copenhagen, 2100, OE, Denmark;Trypanosome Cell Biology Unit, Institut Pasteur and INSERM U1201, 25 rue du Docteur Roux, Paris, 75015, France;Centre de Génétique et de Physiologie Moléculaires et Cellulaires, CNRS UMR 5534, Université Claude Bernard Lyon 1, 16 rue Dubois, Villeurbanne, Lyon F69622, France;Genetics and Genomic Medicine, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK;The Ciliopathy Alliance, 91 Royal College St, NW1 0SE, London;Department of Human Genetics, Radboud University Medical Center, Geert Grooteplein 25, Nijmegen, 6525, GA, The Netherlands;Department of Biosciences and Nutrition, Karolinska Institute, Hälsovägen 7, Huddinge, S-141 83, Sweden;Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, 24 boulevard du Montparnasse, Paris, 75015, France;Department of Nephrology, University Medical Centre Utrecht, 100 Heidelberglaan, Utrecht 3584CX, The Netherlands;UMR7245 CNRS/MNHN, Muséum National d’Histoire Naturelle, 57 rue Cuvier, Paris, 75005, France

关键词: Development;    Hedgehog;    Signalling;    Transport;    Intraflagellar;    Ciliopathies;    Centrioles;    Basal bodies;    Flagella;    Cilia;   

Others  :  1147730
DOI  :  10.1186/s13630-015-0014-0

 received in 2015-02-03, accepted in 2015-02-23,  发布年份 2015

【 摘 要 】

The Cilia 2014 conference was organised by four European networks: the Ciliopathy Alliance, the Groupement de Recherche CIL, the Nordic Cilia and Centrosome Network and the EU FP7 programme SYSCILIA. More than 400 delegates from 27 countries gathered at the Institut Pasteur conference centre in Paris, including 30 patients and patient representatives. The meeting offered a unique opportunity for exchange between different scientific and medical communities. Major highlights included new discoveries about the roles of motile and immotile cilia during development and homeostasis, the mechanism of cilium construction, as well as progress in diagnosis and possible treatment of ciliopathies. The contributions to the cilia field of flagellated infectious eukaryotes and of systems biology were also presented.

【 授权许可】

   
2015 Benmerah et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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Figure 4.

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