Cutaneous mast cell tumor (Mastocytoma): Cyto- histopathological and haematological investigations

Diagnostic Pathology

Radmehr Shafiee¹  Mobin Koohestani⁵  Najme Jaberi Moghaddam⁴  Fatemeh Emami Ghomi²  Javad Javanbakht⁷  Mohammad Hossein Jaberi Moghaddam⁵  Ali Mohammad Bahrami³  Behnam Pedram⁶  Ehsan Hosseini³ 

[1] Graduate, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran;Graduate, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran;Faculty of Para Veterinary Medicine, Ilam University, Ilam, Iran;MSc, Clinical Biochemistry, Tarbiat Modares University, Tehran, Iran;Graduate, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;Department of Pathobiology, Susangerd Branch, Islamic Azad University, Susangerd, Iran;Department of Pathobiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

关键词: Grading;    Mast cell tumor;    Dog;    Pathology;    Cytology;   

Others  :  803489
DOI  :  10.1186/1746-1596-9-9

 received in 2013-12-11, accepted in 2014-01-05,  发布年份 2014

【 摘 要 】

Cutaneous mast cell tumours (MCTs) are the most common skin tumours in dogs. Due to the prevalence of canine MCTs and the variable biologic behavior of this disease, accurate prognostication and a thorough understanding of MCT biology are critical for the treatment of this disease. A cytologic diagnosis of mast cell tumor with evidence of prior hemorrhage was made, and the masses were surgically removed. Cytological evaluation of fine-needle aspirates from the cutaneous mass from the axillary comprised many well-differentiated, highly granulated mast cells with moderate numbers of eosinophils. Nuclei were varied in size and shape with high nuclear’to’cytoplasmic ratio, prominent nucleoli, marked atypical and mitotic figures. Microscopically, mass consisted of sheets of neoplastic round cells that formed nonencapsulated nodules in the dermis and infiltrated into the adjacent dermal collagen, and also there was diffuse subcutis invasion of round to pleomorphic tumor cells. Tumor cells had moderate to abundant cytoplasm, round to ovoid nuclei with scattered chromatin, and mitotic figures. In this tumor, cytoplasmic granules showed atypical metachromasia. In addition, eosinophils were scattered among the mast cells at the periphery of the nodules. The presence of eosinophils and the observation, at high magnification, of cells with cytoplasmic metachromatic granules. Invasion of the deep subcutaneous fat or cutaneous muscles were a common feature of grade III tumour. Finally, a diagnosis of grade III cutaneous mast cell tumor was made.

Virtual slides

The virtual slide(s) of this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4755249151157024 webcite.

【 授权许可】

   
2014 Hosseini et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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