Increase of electronegative-LDL-fraction ratio and IDL-cholesterol in chronic kidney disease patients with hemodialysis treatment

Lipids in Health and Disease

Koichiro Homma²  Joe Yoshizawa²  Yasuhiko Homma³  Yuji Hirowatari¹ 

[1] Bioscience Division, TOSOH CORPORATION, 2743-1 Hayakawa Ayase-shi, Kanagawa, 252-1123, Japan;Department of Emargency Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, 160-8582, Japan;Department of Clinical Health Science, Tokai University School of Medicine, Isehara, Japan

关键词: Anion-exchange chromatographic method;    Hemodialysis;    IDL;    Electronegative-LDL;   

Others  :  1160216
DOI  :  10.1186/1476-511X-11-111

 received in 2012-08-02, accepted in 2012-09-03,  发布年份 2012

【 摘 要 】

Background

It is known that the increased level of IDL and oxidized LDL are associated with risk of cardiovascular disease, and the lipoprotein abnormalities accelerate atherosclerosis. Cardiovascular disease is a major cause of mortality in chronic kidney disease patients with hemodialysis treatment (HD-Ps). Therefore, the estimation of lipoprotein profiles is important for prevention of cardiovascular disease in HD-Ps. We previously established an anion-exchange chromatographic method for measurement of cholesterol level in subclasses of HDL and LDL, IDL, VLDL, and chylomicron. An electronegative-LDL-fraction contained minimally oxidized-LDL. Lipoprotein profile can be accurately and conveniently determined by the new method.

Finding

In this study, lipoprotein profiles in HD-Ps and age-matched healthy subjects were estimated by using our established anion-exchange chromatographic method. The ratio of electronegative-LDL-cholesterol to total LDL-cholesterol and IDL-cholesterol in HD-Ps were significant higher than those in healthy subjects.

Conclusions

The results suggest that the ratio of electronegative-LDL-cholesterol to total LDL-cholesterol and IDL-cholesterol obtained by the new method may serve as useful markers for risk of cardiovascular disease in HD-Ps.

【 授权许可】

   
2012 Hirowatari et al.; licensee BioMed Central Ltd.

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