Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance

Longevity & Healthspan

Oleh V Lushchak¹  Volodymyr I Lushchak³  Mahtab Jafari²  Ihor S Yurkevych³  Dmytro V Gospodaryov³ 

[1] Department of Zoology, Stockholm University, S-10691 Stockholm, Sweden;Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697, USA;Department of Biochemistry and Biotechnology, Vassyl Stefanyk Precarpathian National University, Ivano-Frankivsk 76025, Ukraine

关键词: Rhodiola rosea;    Macronutrient balance;    Longevity;    Fruit fly;    Fecundity;    Diet;    Adaptogen;   

Others  :  803898
DOI  :  10.1186/2046-2395-2-5

 received in 2012-04-19, accepted in 2013-02-11,  发布年份 2013

【 摘 要 】

Background

This study was conducted to evaluate the effects of rhizome powder from the herb Rhodiola rosea, a traditional Western Ukraine medicinal adaptogen, on lifespan and age-related physiological functions of the fruit fly Drosophila melanogaster.

Results

Flies fed food supplemented with 5.0 mg/ml and 10.0 mg/ml of R. rosea rhizome powder had a 14% to 17% higher median lifespan, whereas at 30.0 mg/ml lifespan was decreased by 9% to 12%. The preparation did not decrease fly fecundity.

The effect of R. rosea supplement on lifespan was dependent on diet composition. Lifespan extension by 15% to 21% was observed only for diets with protein-to-carbohydrate ratios less than 1. Lifespan extension was also dependent on total concentration of macronutrients. Thus, for the diet with 15% yeast and 15% sucrose there was no lifespan extension, while for the diet with protein-to-carbohydrate ratio 20:1 R. rosea decreased lifespan by about 10%.

Flies fed Rhodiola preparation were physically more active, less sensitive to the redox-cycling compound menadione and had a longer time of heat coma onset compared with controls. Positive effects of Rhodiola rhizome on stress resistance and locomotor activity were highest at the ‘middle age’.

Conclusions

The present data show that long-term food supplementation with R. rosea rhizome not only increases D. melanogaster lifespan, but also delays age-related decline of physical activity and increases stress resistance, what depends on protein-to-carbohydrate ratio of the diet.

【 授权许可】

   
2013 Gospodaryov et al.; licensee BioMed Central Ltd.

【 图 表 】

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