Atypical glomus tumor arising in the liver: a case report

Diagnostic Pathology

Eiichi Morii¹  Hiroshi Wada⁴  Shigeru Marubashi²  Hidetoshi Eguchi⁴  Hiroaki Nagano³  Takahiro Matsui¹  Katsutoshi Hirose¹ 

[1] Department of Pathology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita 565-0871, Osaka, Japan;Department of Regenerative Surgery, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan;Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, Ube 755-8505, Yamaguchi, Japan;Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita 565-0871, Osaka, Japan

关键词: Synaptophysin;    Atypical features;    Liver;    Glomus tumor;   

Others  :  1220743
DOI  :  10.1186/s13000-015-0355-4

 received in 2015-05-08, accepted in 2015-07-09,  发布年份 2015

【 摘 要 】

Background

Glomus tumors typically occur in the subcutaneous tissue of distal extremities, but rarely in visceral organs. Most glomus tumors are benign, while others have been reported to have malignant potential. Herein, a unique case of a liver glomus tumor with atypical histological features is reported.

Case presentation

A 39-year-old man felt fullness in the epigastrium, and an enhanced computed tomography (CT) scan of the abdomen and pelvis revealed a 21-cm solid and cystic mass in the left liver lobe. The patient underwent a left hepatic lobectomy, and the tumor was pathologically identified as a glomus tumor with atypical histological features in the liver. This case is unique for three reasons. First, cases of glomus tumors in the liver are extremely rare. Second, this is the first report of a hepatic glomus tumor with histologically atypical features. Third, immunohistochemical staining showed focal positivity for synaptophysin. A literature review revealed that glomus tumors in visceral organs positive for synaptophysin show histological atypical features in most cases.

Conclusions

This is the first case of a glomus tumor with atypical histological features arising in the liver. This unique case and literature review yielded interesting findings and enabled us to postulate that synaptophysin positivity may be indicative of atypical histological features in glomus tumors arising in visceral organs.

【 授权许可】

   
2015 Hirose et al.

【 图 表 】

Fig. 1.

Fig. 2.

Fig. 3.

Fig. 4.

Fig. 5.

【 参考文献 】

• [1]Mravic M, LaChaud G, Nguyen A, Scott MA, Dry SM, James AW. Clinical and histopathological diagnosis of glomus tumor: an institutional experience of 138 cases. Int J Surg Pathol. 2015; 23:181-8.
• [2]Miettinen M, Paal E, Lasota J, Sobin LH. Gastrointestinal glomus tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 32 cases. Am J Surg Pathol. 2002; 26:301-11.
• [3]Gaertner EM, Steinberg DM, Huber M, Hayashi T, Tsuda N, Askin FB et al.. Pulmonary and mediastinal glomus tumors--report of five cases including a pulmonary glomangiosarcoma: a clinicopathologic study with literature review. Am J Surg Pathol. 2000; 24:1105-14.
• [4]Tripodi SA, Rocca BJ, Mourmouras V, Barbanti G, Colecchia M, Ambrosio MR. Benign glomus tumor of the urinary bladder. Arch Pathol Lab Med. 2013; 137:1005-8.
• [5]Gill J, Van Vliet C. Infiltrating glomus tumor of uncertain malignant potential arising in the kidney. Hum Pathol. 2010; 41:145-9.
• [6]Masson-Lecomte A, Rocher L, Ferlicot S, Benoît G, Droupy S. High-flow priapism due to a malignant glomus tumor (glomangiosarcoma) of the corpus cavernosum. J Sex Med. 2011; 8:3518-22.
• [7]Gassel HJ, Klein I, Timmermann W, Kenn W, Gassel AM, Thiede A. Presentation of an unusual benign liver tumor: primary hepatic glomangioma. Scand J Gastroenterol. 2002; 37:1237-40.
• [8]Kenn W, Klein I, Gassel HJ, Gattenloehner S, Gassel AM, Hahn D. Primary glomangioma of the liver: imaging findings. Abdom Imaging. 2002; 27:716-9.
• [9]Jaiswal VR, Champine JG, Sharma S, Molberg KH. Primary glomangioma of the liver: a case report and review of the literature. Arch Pathol Lab Med. 2004; 128:e46-9.
• [10]Geramizadeh B, Nikeghbalian S, Shamsaifar A, Kazemi K, Tavoosi H, Sefidbakht S et al.. Primary glomus tumor of the liver: a rare case report and review of the literature. Indian J Pathol Microbiol. 2011; 54:584-7.
• [11]Amoueian S, Meibodi NT, Tavoosi H, Ekramifard VR, Attaranzadeh A, Montazer M. Primary glomus tumor of the liver. Arch Iran Med. 2011; 14:294-5.
• [12]Kihara A, Fukushima J, Horiuchi H. Glomus tumor of the liver presenting as a cystic lesion. Pathol Int. 2014; 64:295-7.
• [13]Folpe AL, Fanburg-Smith JC, Miettinen M, Weiss SW. Atypical and malignant glomus tumors: analysis of 52 cases, with a proposal for the reclassification of glomus tumors. Am J Surg Pathol. 2001; 25:1-12.
• [14]Song SE, Lee CH, Kim KA, Lee HJ, Park CM. Malignant glomus tumor of the stomach with multiorgan metastases: report of a case. Surg Today. 2010; 40:662-7.
• [15]Zhang Y, Li H, Zhang WQ. Malignant glomus tumor of the esophagus with mediastinal lymph node metastases. Ann Thorac Surg. 2013; 96:1464-6.
• [16]Lamba G, Rafiyath SM, Kaur H, Khan S, Singh P, Hamilton AM et al.. Malignant glomus tumor of kidney: the first reported case and review of literature. Hum Pathol. 2011; 42:1200-3.
• [17]Bali GS, Hartman DJ, Haight JB, Gibson MK. A rare case of malignant glomus tumor of the esophagus. Case Rep Oncol Med. 2013; 2013:287078.
• [18]Nakajima Y, Koizumi K, Haraguchi S, Kawamoto M, Kubokura H, Okada D et al.. Locally infiltrative glomus tumor of the bronchus: a case report. Ann Thorac Cardiovasc Surg. 2010; 16:113-7.
• [19]Jundi M, Lack EE, Brun EA, Esquivel J, Kumar D. Glomus tumor of the duodenum: a case report. Int J Surg Pathol. 2004; 12:411-4.