Airway transplantation: a challenge for regenerative medicine

European Journal of Medical Research

Alain Carpentier⁶  Dominique Valeyre⁷  Christophe Baillard³  Charles-Hugo Marquette⁵  Nicolas Vénissac⁸  Hervé Dutau¹  Anne Fialaire-Legendre⁴  Kader Chouahnia²  Guillaume Boddaert⁶  Dana M Radu⁶  Agathe Seguin⁶  Emmanuel Martinod⁶ 

[1] Assistance Publique-Hôpitaux de Marseille, Thoracic Oncology, Pleural Diseases and Interventional Pulmonology Department, North University Hospital, Marseille, France;Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Avicenne Hospital, Department of Oncology, Paris 13 University, Sorbonne Paris Cité, Faculty of Medicine SMBH, Bobigny, France;Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Avicenne Hospital, Department of Anesthesiology and Intensive Care, Paris 13 University, Sorbonne Paris Cité, Faculty of Medicine SMBH, Bobigny, France;Assistance Publique-Hôpitaux de Paris, Saint Antoine Hospital, EFS Ile de France, Tissue Bank, Paris, France;CHU Nice, Pasteur Hospital, Department of Pneumology, Nice, France;Alain Carpentier Foundation, EA Laboratory for Biosurgical Research, Assistance Publique-Hôpitaux de Paris, George Pompidou European Hospital, Paris Descartes University, Paris, France;Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Avicenne Hospital, Department of Pneumonology, Paris 13 University, Sorbonne Paris Cité, Faculty of Medicine SMBH, Bobigny, France;CHU Nice, Pasteur Hospital, Department of Thoracic Surgery, Nice, France

关键词: Tracheal surgery;    Tracheal disease;    Lung cancer surgery;    Homograft;    Bronchial disease;    Aorta/aortic;    Allograft;    Airway;   

Others  :  819996
DOI  :  10.1186/2047-783X-18-25

 received in 2013-01-01, accepted in 2013-06-20,  发布年份 2013

【 摘 要 】

After more than 50 years of research, airway transplantation remains a major challenge in the fields of thoracic surgery and regenerative medicine. Five principal types of tracheobronchial substitutes, including synthetic prostheses, bioprostheses, allografts, autografts and bioengineered conduits have been evaluated experimentally in numerous studies. However, none of these works have provided a standardized technique for the replacement of the airways. More recently, few clinical attempts have offered encouraging results with ex vivo or stem cell–based engineered airways and tracheal allografts implanted after heterotopic revascularization. In 1997, we proposed a novel approach: the use of aortic grafts as a biological matrix for extensive airway reconstruction. In vivo regeneration of epithelium and cartilage were demonstrated in animal models. This led to the first human applications using cryopreserved aortic allografts that present key advantages because they are available in tissue banks and do not require immunosuppressive therapy. Favorable results obtained in pioneering cases have to be confirmed in larger series of patients with extensive tracheobronchial diseases.

【 授权许可】

   
2013 Martinod et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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