Impact of gastro-oesophageal reflux disease on work productivity despite therapy with proton pump inhibitors in Germany

European Journal of Medical Research

B Brueggenjuergen¹  H Walther³  J Burkowitz¹  U Beckenbauer³  M Gross² 

[1] Alpha Care GmbH, Celle, Germany;Internistische Klinik Dr Müller, München, Germany;H-M-O Health Management Online AG, Oberhaching, Germany

关键词: Proton Pump Inhibitors;    Medical economics;    Sick leave;    Gastro-oesophageal reflux;   

Others  :  1093277
DOI  :  10.1186/2047-783X-15-3-124

 received in 2009-08-20, accepted in 2009-09-08,  发布年份 2010

【 摘 要 】

Background

Gastro-oesophageal reflux disease (GERD) is a common disorder with consequences for the patient's health-related quality of life (HRQoL). In Germany, few data are available on the impact of GERD on work-related productivity.

Aim

To study the impact of GERD on work productivity despite proton pump inhibitor (PPI) therapy and the association between productivity and symptom duration, severity, and HRQoL.

Methods

Retrospective data from randomly selected patients with chronic GERD symptoms, treated by office-based general practitioners or general internists with routine clinical care, were analyzed together with information from self-administered instruments assessing work productivity (WPAI-GERD), symptoms (RDQ), and HRQoL (QOLRAD).

Results

Reduced productivity was reported by 152 of 249 patients (61.0%), although 89.5% of them were treated with PPI. The reduction in work productivity was 18.5% in all patients and 30.3% in those with reduced productivity. Patients with impaired productivity showed a significantly lower HRQoL and more-severe symptoms of reflux disease. In all patients, the mean sick leave attributable to reflux symptoms was 0.6 hours in the previous seven days and 1.4 work days in the previous three months.

Conclusion

GERD has a substantial impact on work productivity in Germany, even in patients receiving routine clinical care and PPI therapy.

【 授权许可】

   
2010 I. Holzapfel Publishers

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