The role of peptide and DNA vaccines in myeloid leukemia immunotherapy

Cancer Cell International

Yangqiu Li¹  Chen Lin² 

[1] Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, China;Department of Microbiology and Immunology, Medical College, Jinan University, Guangzhou, 510632, China

关键词: Immunotherapy;    Myeloid leukemia;    Leukemia-associated antigen;    Peptide vaccine;    DNA vaccine;   

Others  :  794368
DOI  :  10.1186/1475-2867-13-13

 received in 2013-01-23, accepted in 2013-02-06,  发布年份 2013

【 摘 要 】

While chemotherapy and targeted therapy are successful in inducing the remission of myeloid leukemia as acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), the disease remains largely incurable. This observation is likely due to the drug resistance of leukemic cells, which are responsible for disease relapse. Myeloid leukemia vaccines may most likely be beneficial for eradicating minimal residual disease after treatment with chemotherapy or targeted therapy. Several targeted immunotherapies using leukemia vaccines have been heavily investigated in clinical and preclinical trials. This review will focus on peptides and DNA vaccines in the context of myeloid leukemias, and optimal strategies for enhancing the efficacy of vaccines based on myeloid leukemia immunization are also summarized.

【 授权许可】

   
2013 Lin and Li; licensee BioMed Central Ltd.

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