Analysis of nitric oxide synthase gene polymorphisms in neonatal respiratory distress syndrome among the Chinese Han population

Italian Journal of Pediatrics

Qiyi Zeng¹  Bin Wang¹  Jiang Du¹  Wei Shen¹ 

[1] Center of pediatrics, Zhujiang Hospital, Southern Medical university, Guangzhou, Guangdong 510282, China

关键词: Polymorphism;    Multiplex ligation detection reaction;    Preterm infants;    Respiratory distress syndrome;    Nitric oxide synthase;   

Others  :  804849
DOI  :  10.1186/1824-7288-40-27

 received in 2013-12-18, accepted in 2014-03-02,  发布年份 2014

【 摘 要 】

Aim

To evaluate the association of NOS1 and NOS3 gene polymorphisms with the risk/severity of neonatal respiratory distress syndrome (RDS) among preterm infants.

Methods

The patient group was 189 preterm infants diagnosed with RDS. The control group was 227 preterm neonates who did not develop RDS. NOS genotyping was performed using an improved multiplex ligation detection reaction (iMLDR) technique based on LDR.

Results

It was found that genotype and allele frequencies of rs2682826 of the NOS1 gene and rs1799983 of the NOS3 gene were not significantly different between the RDS group and the control group. However, when the preterm infants were divided into two and three groups based on gestational age and birth weight, a study of the SNP rs1799983 of the NOS3 gene showed that the GG genotype and G allele frequencies were significantly increased in the RDS groups, the GT genotype and A allele were less frequent among the RDS groups in 26–32.9 weeks of gestational age and in a birth weight subgroup of <1.5 Kg.

Conclusion

Our study raises the possibility that a genetic variation of NOS3 could be implicated in the pathophysiology of RDS in the Chinese Han population, especially in very preterm and very low birth weight infants.

【 授权许可】

   
2014 Shen et al.; licensee BioMed Central Ltd.

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