Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13800 patients and 23340 controls in 19 observational studies

Lipids in Health and Disease

Demosthenes B Panagiotakos⁴  Meletios Dimopoulos³  Dimitrios Haidopoulos¹  Rena I Kosti²  Theodora Psaltopoulou² 

[1] Department of Obstetrics and Gynaecology, "Alexandra" Hospital, School of Medicine, University of Athens, Vas.Sofias 80, Goudi, 11528, Athens, Greece;Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, M. Asias 75, Goudi, 11527, Athens, Greece;Department of Clinical Therapeutics, "Alexandra" Hospital, School of Medicine, University of Athens, Vas.Sofias 80, Goudi, 11528, Athens, Greece;Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou str., Kallithea, 17671, Athens, Greece

关键词: meta-analysis;    systematic;    review;    Mediterranean diet;    olive oil;    cancer;   

Others  :  1212572
DOI  :  10.1186/1476-511X-10-127

 received in 2011-06-19, accepted in 2011-07-30,  发布年份 2011

【 摘 要 】

Dietary fat, both in terms of quantity and quality, has been implicated to cancer development, either positively or negatively. The aim of this work was to evaluate whether olive oil or monounsaturated fat intake was associated with the development of cancer. A systematic search of relevant studies, published in English, between 1990 and March 1, 2011, was performed through a computer-assisted literature tool (i.e., Pubmed). In total 38 studies were initially allocated; of them 19 case-control studies were finally studied (13800 cancer patients and 23340 controls were included). Random effects meta-analysis was applied in order to evaluate the research hypothesis. It was found that compared with the lowest, the highest category of olive oil consumption was associated with lower odds of having any type of cancer (log odds ratio = -0.41, 95%CI -0.53, -0.29, Cohran's Q = 47.52, p = 0.0002, I-sq = 62%); the latter was irrespective of the country of origin (Mediterranean or non-Mediterranean). Moreover, olive oil consumption was associated with lower odds of developing breast cancer (logOR = -0,45 95%CI -0.78 to -0.12), and a cancer of the digestive system (logOR = -0,36 95%CI -0.50 to -0.21), compared with the lowest intake. The strength and consistency of the findings states a hypothesis about the protective role of olive oil intake on cancer risk. However, it is still unclear whether olive oil's monounsaturated fatty acid content or its antioxidant components are responsible for its beneficial effects.

【 授权许可】

   
2011 Psaltopoulou et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Perez-Jimenez F, Alvarez de Cienfuegos G, Badimon L, Barja G, Battino M, Blanco A, Bonanome A, Colomer R, Corella-Piquer D, Covas I, Chamorro-Quiros J, Escrich E, Gaforio JJ, Garcia Luna PP, Hidalgo L, Kafatos A, Kris-Etherton PM, Lairon D, Lamuela-Raventos R, Lopez-Miranda J, Lopez-Segura F, Martinez-Gonzalez MA, Mata P, Mataix J, Ordovas J, Osada J, Pacheco-Reyes R, Perucho M, Pineda-Priego M, Quiles JL, Ramirez-Tortosa MC, Ruiz-Gutierrez V, Sanchez-Rovira P, Solfrizzi V, Soriguer-Escofet F, de la Torre-Fornell R, Trichopoulos A, Villalba-Montoro JM, Villar-Ortiz JR, Visioli F: International conference on the healthy effect of virgin olive oil. Eur J Clin Invest 2005, 35:421-424. Review
• [2]Giacosa A: The Mediterranean diet and its protective role against cancer. Eur J Cancer Prev 2004, 13:155-157.
• [3]Kushi L, Giovanucci E: Dietary fat and cancer. Am J Clin Nutr 2002, 113:63-70.
• [4]Lipworth L, Martinez ME, Angell J, Hsieh CC, Trichopoulos D: Olive oil and human cancer: an assessment of the evidence. Prev Med 1997, 26:181-190.
• [5]Owen RW, Giacosa A, Hull WE, Haubner R, Spiegelhalder B, Bartsch H: The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. Eur J Cancer 2000, 36:1235-1247.
• [6]Owen RW, Giacosa A, Hull WE, Haubner R, Würtele G, Spiegelhalder B, Bartsch H: Olive-oil consumption and health: the possible role of antioxidants. Lancet Oncol 2000, 1:107-112. Review
• [7]Visioli F, Grande S, Bogani P, Galli C: The role of antioxidants in the Mediterranean diets: focus on cancer. Eur J Cancer Prev 2004, 13:337-343. Review
• [8]Martin-Moreno JM: The role of olive oil in lowering cancer risk: is this real gold or simply pinchbeck? J Epidemiol Community Health 2000, 54:726-727.
• [9]Stroup D, Berlin J, Morton S, Olkin I, Williamson G, Rennie D, Moher D, Becker B, Sipe T, Thacker S, for the Meta-analysis of Observational Studies in Epidemiology (MOOSE) Group: Meta-analysis of Observational Studies in Epidemiology. A proposal for reporting. JAMA 2000, 283:2008-2012.
• [10]Trichopoulou A, Katsouyanni K, Stuver S, Tzala L, Gnardellis C, Rimm E, Trichopoulos D: Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. J Natl Cancer Inst 1995, 87:110-116.
• [11]Katsouyanni K, Trichopoulou A, Stuver S, Garas Y, Kritselis A, Kyriakou G, Stoïkidou M, Boyle P, Trichopoulos D: The association of fat and other macronutrients with breast cancer: a case-control study from Greece. Br J Cancer 1994, 70:537-541.
• [12]Trichopoulou A, Bamia C, Lagiou P, Trichopoulos D: Conformity to traditional Mediterranean diet and breast cancer risk in the Greek EPIC (European Prospective Investigation into Cancer and Nutrition) cohort. Am J Clin Nutr 2010, 92:620-625.
• [13]Martin-Moreno JM, Willett WC, Gorgojo L, Banegas JR, Rodriguez-Artalejo F, Fernandez-Rodriguez JC, Maisonneuve P, Boyle P: Dietary fat, olive oil intake and breast cancer risk. Int J Cancer 1994, 58:774-80.
• [14]Landa MC, Frago N, Tres A: Diet and the risk of breast cancer in Spain. Eur J Cancer Prev 1994, 3:313-320.
• [15]García-Segovia P, Sánchez-Villegas A, Doreste J, Santana F, Serra-Majem L: Olive oil consumption and risk of breast cancer in the Canary Islands: a population-based case-control study. Public Health Nutr 2006, 9:163-167.
• [16]La Vecchia C, Negri E, Franceschi S, Decarli A, Giacosa A, Lipworth L: Olive oil, other dietary fats and the risk of breast cancer (Italy). Cancer Causes Control 1995, 6:545-550.
• [17]Sieri S, Krogh V, Pala V, Muti P, Micheli A, Evangelista A, Tagliabue G, Berrino F: Dietary patterns and risk of breast cancer in the ORDET cohort. Cancer Epidemiol Biomarkers Prev 2004, 13:567-572.
• [18]Bessaoud F, Daurès JP, Gerber M: Dietary factors and breast cancer risk: a case control study among a population in Southern France. Nutr Cancer 2008, 60:177-187.
• [19]Cottet V, Touvier M, Fournier A, Touillaud MS, Lafay L, Clavel-Chapelon F, Boutron-Ruault MC: Postmenopausal breast cancer risk and dietary patterns in the E3N-EPIC prospective cohort study. Am J Epidemiol 2009, 170:1257-1267.
• [20]Richardson S, Gerber M, Cenée S: The role of fat, animal protein and some vitamin consumption in breast cancer: a case control study in southern France. Int J Cancer 1991, 48:1-9.
• [21]Simonsen NR, Fernandez-Crehuet Navajas J, Martin-Moreno JM, Strain JJ, Huttunen JK, Martin BC, Thamm M, Kardinaal AF, van't Veer P, Kok FJ, Kohlmeier L: Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. Am J Clin Nutr 1998, 68:134-141.
• [22]Howe GR, Aronson KJ, Benito E, Castelleto R, Cornée J, Duffy S, Gallagher RP, Iscovich JM, Deng-ao J, Kaaks R, Kune GA, Kune S, Lee HP, Lee M, Miller AB, Peters RK, Potter JD, Riboli E, Slattery ML, Trichopoulos D, Tuyns A, Tzonou A, Watson LF, Whittemore AS, Shu Z: The relationship between dietary fat intake and risk of colorectal cancer: evidence from the combined analysis of 13 case-control studies. Cancer Causes Control 1997, 8:215-228.
• [23]Nkondjock A, Shatenstein B, Maisonneuve P, Ghadirian P: Specific fatty acids and human colorectal cancer: an overview. Cancer Detect Prev 2003, 27:55-66.
• [24]Giovannucci E, Willett WC: Dietary factors and risk of colon cancer. Ann Med 1994, 26:443-452.
• [25]Braga C, La Vecchia C, Franceschi S, Negri E, Parpinel M, Decarli A, Giacosa A, Trichopoulos D: Olive oil, other seasoning fats and the risk of colorectal carcinoma. Cancer 1998, 82:448-453.
• [26]Franceschi S: Nutrients and food groups and large bowel cancer in Europe. Eur J Cancer Prev 1999, 8(Suppl 1):49-52.
• [27]Franceschi S, Favero A: The role of energy and fat in cancers of the breast and colon-rectum in a southern European population. Ann Oncol 1999, 10(Suppl 6):61-63.
• [28]Franceschi S, La Vecchia C, Russo A, Favero A, Negri E, Conti E, Montella M, Filiberti R, Amadori D, Decarli A: Macronutrient intake and risk of colorectal cancer in Italy. Int J Cancer 1998, 76:321-324.
• [29]Benito E, Stiggelbout A, Bosch FX, Obrador A, Kaldor J, Mulet M, Muñoz N: Nutritional factors in colorectal cancer risk: a case-control study in Majorca. Int J Cancer 1991, 49:161-167.
• [30]Galeone C, Talamini R, Levi F, Pelucchi C, Negri E, Giacosa A, Montella M, Franceschi S, La Vecchia C: Fried foods, olive oil and colorectal cancer. Ann Oncol 2007, 18:36-39.
• [31]Levi F, Pasche C, Lucchini F, La Vecchia C: Macronutrient and colorectal cancer: a Swiss case-control study. Ann Oncol 2002, 13:369-373.
• [32]Jarvinen R, Knekt P, Hakulinen T, Rissanen H, Heliovaara M: Dietary fat, cholesterol and colorectal cancer in a prospective study. Br J Cancer 2001, 85:357-361.
• [33]Gaard M, Tretli S, Loken EB: Dietary factors and risk of colon cancer: a prospective study of 50,535 young Norwegian men and women. Eur J Cancer Prev 1996, 5:445-454.
• [34]Tzonou A, Signorello LB, Lagiou P, Wuu J, Trichopoulos D, Trichopoulou A: Diet and cancer of the prostate: a case-control study in Greece. Int J Cancer 1999, 80:704-708.
• [35]Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM: Men who consume vegetable oils rich in monounsaturated fat: their dietary patterns and risk of prostate cancer (New Zealand). Cancer Causes Control 2000, 11:609-615.
• [36]Hodge A, English D, McCredie M, Severi G, Boyle P, Hopper JL, Giles GG: Foods, nutrients and prostate cancer. Cancer Causes and Control 2004, 15:11-20.
• [37]Kristal AR, Cohen JH, Qu P, Stanford JL: Associations of energy, fat, calcium, and vitamin D with prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2002, 11:719-725.
• [38]Kim DJ, Gallagher RP, Hislop TG, Holowaty EJ, Howe GR, Jain M, McLaughlin JR, Teh CZ, Rohan TE: Premorbid diet in relation to survival from prostate cancer (Canada). Cancer Causes Control 2000, 11:65-77.
• [39]Andersson SO, Wolk A, Bergstrom R, Giovanucci E, Lindgren C, Baron J, Adami HO: Energy, nutrient intake and prostate cancer risk: a population-based case-control study in Sweden. Int J Cancer 1996, 68:716-722.
• [40]Gallus S, Bosetti C, Francescho S, Levi F, Negri E, La Vecchia C: Laryngeal cancer in women. Tobacco, alcohol, nutritional and hormonal factors. Cancer Epidemiol Biom Prev 2003, 12:514-517.
• [41]Crosignani P, Russo A, Tagliabue G, Berrino F: Tobacco and diet as determinants of survival in male laryngeal cancer patients. Int J Cancer 1996, 65:308-313.
• [42]Russo A, Crosignani P, Berrino F: Tobacco smoking, alcohol drinking and dietary factors as determinants of new primaries among male laryngeal cancer patients: a case-cohort study. Tumori 1996, 82:519-525.
• [43]Bosetti C, La Vecchia C, Talamini R, Negri E, Levi F, Dal Maso L, Franceschi S: Food groups and laryngeal cancer risk: a case-control study from Italy and Switzerland. Int J Cancer 2002, 100:355-360.
• [44]Lagiou P, Talamini R, Samoli E, Lagiou A, Ahrens W, Pohlabeln H, Benhamou S, Bouchardy C, Slamova A, Schejbalova M, Merletti F, Richiardi L, Kjaerheim K, Agudo A, Castellsague X, Macfarlane TV, Macfarlane GJ, Biggs AM, Barzan L, Canova C, Simonato L, Lowry RJ, Conway DI, McKinney PA, Znaor A, McCartan BE, Healy CM, Marron M, Hashibe M, Brennan P: Diet and upper-aerodigestive tract cancer in Europe: the ARCAGE study. Int J Cancer 2009, 124:2671-2676.
• [45]Garavello W, Lucenteforte E, Bosetti C, La Vecchia C: The role of foods and nutrients on oral and pharyngeal cancer risk. Minerva Stomatol 2009, 58:25-34.
• [46]Franceschi S, Favero A, Conti E, Talamini R, Volpe R, Negri E, Barzan L, La Vecchia C: Food groups, oils and butter, and cancer of the oral cavity and pharynx. Br J Cancer 1999, 80:614-620.
• [47]Nesić V, Sipetić S, Vlajinac H, Stosić-Divjak S, Jesić S: Risk factors for the occurrence of undifferentiated carcinoma of nasopharyngeal type: a case-control study. Srp Arh Celok Lek 2010, 138:6-10.
• [48]Petridou E, Zavras A, Lefatzis D, Conti E, Talamini R, Volpe R, Negri E, Barzan L, La Vecchia C: The role of diet and specific micronutrients in the etiology of oral carcinoma. Cancer 2002, 94:2981-2988.
• [49]Samoli E, Lagiou A, Nikolopoulos E, Lagogiannis G, Barbouni A, Lefantzis D, Trichopoulos D, Brennan P, Lagiou P: Mediterranean diet and upper aerodigestive tract cancer: the Greek segment of the Alcohol-Related Cancers and Genetic Susceptibility in Europe study. Br J Nutr 2010, 101:369-374.
• [50]Tzonou A, Lipworth L, Garidou A, Signorello LB, Lagiou P, Hsieh C, Trichopoulos D: Diet and risk of esophageal cancer by histologic type in a low-risk population. Int J Cancer 1996, 68:300-304.
• [51]Bosetti C, La Vecchia C, Talamini R, Negri E, Levi F, Dal Maso L, Franceschi S: Food groups and risk of squamous cell esophageal cancer in northern Italy. Int J Cancer 2000, 87:289-294.
• [52]Franceschi S, Bidoli E, Negri E, Zambon P, Talamini R, Ruol A, Parpinel M, Levi F, Simonato L, La Vecchia C: Role of macronutrients, vitamins and minerals in the aetiology of squamous-cell carcinoma of the oesophagus. Int J Cancer 2000, 86:626-631.
• [53]Launoy G, Milan C, Day NE, Pienkowski MP, Gignoux M, Faivre J: Diet and squamous-cell cancer of the oesophagus: a French multicenter case-control study. Int J Cancer 1998, 76:7-12.
• [54]Palli D, Russo A, Ottini L, Masala G, Saieva C, Amorosi A, Cama A, D'Amico C, Falchetti M, Palmirotta R, Decarli A, Mariani Costantini R, Fraumeni JF Jr: Red meat, family history, and increased risk of gastric cancer with microsatellite instability. Cancer Res 2001, 61:5415-5419.
• [55]Buiatti E, Palli D, Decarli A, Amadori D, Avellini C, Bianchi S, Bonaguri C, Cipriani F, Cocco P, Giacosa A: A case-control study of gastric cancer and diet in Italy: II. Association with nutrients. Int J Cancer 1990, 45:896-901.
• [56]Fortes C, Forastiere F, Farchi S, Mallone S, Trequattrinni T, Anatra F, Schmid G, Perucci CA: The protective effect of the Mediterranean diet on lung cancer. Nutr Cancer 2003, 46:30-37.
• [57]Smith-Warner SA, Ritz J, Hunter DJ, Albanes D, Beeson WL, van den Brandt PA, Colditz G, Folsom AR, Fraser GE, Freudenheim JL, Giovannucci E, Goldbohm RA, Graham S, Kushi LH, Miller AB, Rohan TE, Speizer FE, Virtamo J, Willett WC: Dietary fat and risk of lung cancer in a pooled analysis of prospective studies. Cancer Epidemiol Biomarkers Prev 2002, 11(10 Pt 1):987-992.
• [58]Bandera EV, Freudenheim JL, Marshall JR, Zielezny M, Priore RL, Brasure J, Baptiste M, Graham S: Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States). Cancer Causes Control 1997, 8:828-840.
• [59]Veierød MB, Laake P, Thelle DS: Dietary fat intake and risk of lung cancer: a prospective study of 51452 Norwegian men and women. Eur J Cancer Prev 1997, 6:540-549.
• [60]Tzonou A, Hsieh CC, Polychronopoulou A, Kaprinis G, Toupadaki N, Trichopoulou A, Karakatsani A, Trichopoulos D: Diet and ovarian cancer: a case-control study in Greece. Int J Cancer 1993, 55:411-414.
• [61]Bosetti C, Negri E, Franceschi S, Talamini R, Montella M, Conti E, Lagiou P, Parazzini F, La Vecchia C: Olive oil, seed oils and other added fats in relation to ovarian cancer (Italy). Cancer Causes Control 2002, 13:465-470.
• [62]Bidoli E, La Vecchia C, Montella M, Maso LD, Conti E, Negri E, Scarabelli C, Carbone A, Decarli A, Franceschi S: Nutrient intake and ovarian cancer: an Italian case-control study. Cancer Causes Control 2002, 13:255-261.
• [63]Pan SY, Ugnat AM, Mao Y, Wen SW, Johnson KC, Canadian Cancer Registries Epidemiology Research Group: Association of cigarette smoking with the risk of ovarian cancer. Int J Cancer 2004, 111:124-130.
• [64]Bertone ER, Rosner BA, Hunter DJ, Stampfer MJ, Speizer FE, Colditz GA, Willett WC, Hankinson SE: Dietary fat intake and ovarian cancer in a cohort of US women. Am J Epidemiol 2002, 156:22-31.
• [65]Levi F, Franceschi S, Negri E, La Vecchia C: Dietary factors and the risk of endometrial cancer. Cancer 1993, 71:3575-3581.
• [66]Tzonou A, Lipworth L, Kalandidi A, Trichopoulou A, Gamatsi I, Hsieh CC, Notara V, Trichopoulos D: Dietary factors and the risk of endometrial cancer: a case-control study in Greece. Br J Cancer 1996, 73:1284-1290.
• [67]Petridou E, Kedikoglou S, Koukoulomatis P, Dessypris N, Trichopoulos D: Diet in relation to endometrial cancer risk: a case-control study in Greece. Nutr Cancer 2002, 44:16-22.
• [68]Kalapothaki V, Tzonou A, Hsieh CC, Karakatsani A, Trichopoulou A, Toupadaki N, Trichopoulos D: Nutrient intake and cancer of the pancreas: a case-control study in Athens, Greece. Cancer Causes Control 1993, 4:383-389.
• [69]Soler M, Chatenoud L, La Vecchia C, Francheschi S, Negri E: Diet, alcohol, coffee and pancreatic cancer: final results from an Italian study. Eur J Cancer Prev 1998, 7:455-460.
• [70]La Vecchia C, Negri : Fats in seasoning and the relationship to pancreatic cancer. Eur J Cancer Prev 1997, 6:370-373.
• [71]Nkondjock A, Krewski D, Johnson KC, Ghadirian P, Canadian Cancer Registries Epidemiology Research Group: Specific fatty acid intake and the risk of pancreatic cancer in Canada. Br J Cancer 2005, 92:971-977.
• [72]Michaud DS, Giovannucci E, Willett WC, Colditz GA, Fuchs CS: Dietary meat, dairy products, fat, and cholesterol and pancreatic cancer risk in a prospective study. Am J Epidemiol 2003, 157:1115-1125.
• [73]Stolzenberg-Solomon RZ, Pietinen P, Taylor PR, Virtamo J, Albanes D: Prospective study of diet and pancreatic cancer in male smokers. Am J Epidemiol 2002, 155:783-792.
• [74]Brinkman MT, Buntinx F, Kellen E, Van Dongen MC, Dagnelie PC, Muls E, Zeegers MP: Consumption of animal products, olive oil and dietary fat and results from the Belgian case-control study on bladder cancer risk. Eur J Cancer 2011, 47:436-442.
• [75]Riboli E, González CA, López-Abente G, Errezola M, Izarzugaza I, Escolar A, Nebot M, Hémon B, Agudo A: Diet and bladder cancer in Spain: a multi-centre case-control study. Int J Cancer 1991, 49:214-219.
• [76]Comba A, Maestri DM, Berra MA, Garcia CP, Das UN, Eynard AR, Pasqualini ME: Effect of ω-3 and ω-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model. Lipids Health Dis 2010, 9:112. BioMed Central Full Text
• [77]Sofi F, Cesari F, Abbate R, Gensini GF, Casini A: Adherence to Mediterranean diet and health status: meta-analysis. BMJ 2008, 337:1136-1144.
• [78]Trichopoulou A, Costacou T, Bamia C, Trichopoulos D: Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003, 348:2599-2608.
• [79]Trichopoulou A, Lagiou P, Kuper H, Trichopoulos D: Cancer and Mediterranean dietary traditions. Cancer Epidemiol Biomarkers Prev 2000, 9:869-873. Review
• [80]Stoneham M, Goldacre M, Seagroatt V, Gill L: Olive oil, diet and colorectal cancer: an ecological study and a hypothesis. J Epidemiol Community Health 2000, 54:756-760.
• [81]Saadatian-Elahi M, Norat T, Goudable J, Riboli E: Biomarkers of dietary fatty acids intake and the risk of breast cancer: a meta-analysis. Int J Cancer 2004, 111:584-591.
• [82]Owen RW, Haubner R, Wurtele G, Hull E, Spiegelhalder B, Bartsch H: Olives and olive oil in cancer prevention. Eur J Cancer Prev 2004, 13:319-326.