Phylloquinone supplementation improves glycemic status independent of the effects of adiponectin levels in premonopause women with prediabetes: a double-blind randomized controlled clinical trial

Journal of Diabetes & Metabolic Disorders

Hajieh Shahbazian³  Azadeh Saki¹  Mehdi Zarei⁴  Majid Mohammadshahi²  Mohammad-Taha Jalali⁵  Majid Karandish²  Hamid Rasekhi² 

[1] Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran;Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

关键词: Prediabetes;    Adiponectin;    Osteocalcin;    Vitamin K1;    Phylloquinone;   

Others  :  1133303
DOI  :  10.1186/s40200-014-0127-9

 received in 2014-07-06, accepted in 2014-12-28,  发布年份 2015

【 摘 要 】

Background

Vitamin K, as a cofactor in the gamma carboxylation of certain glutamic acid (Gla) residues, has been related to glucose metabolism and insulin sensitivity. Osteocalcin, also known as bone γ-carboxyglutamic acid, increases β-cell proliferation as well as insulin and adiponectin secretion, which improve glucose tolerance and insulin sensitivity. Thus, the purpose of the present study was to examine the possible role of adiponectin as a mediator of glucose homeostasis following phylloquinone supplementation in premonopause women with prediabetes.

Methods

Eighty two women were randomized to consume vitamin k1 supplement (n = 39) or placebo (n = 43) for four weeks. Participants in vitamin K1 treatment group received one pearl softgel capsule containing 1000 micrograms phylloquinone while the placebo group received one placebo capsules daily for four weeks. The Blood samples were collected at baseline and after a four-week intervention to quantify osteocalcin, adiponectin, leptin and relevant variables.

Results

Phylloquinone supplementation significantly increased serum adiponectin concentration (1.24 ± 1.90 compared with −0.27 ± 1.08 μg/ml), and did not alter total osteocalcin (0.50 ± 4.11 compared with 0.13 ± 1.85 ng/ml) and leptin (−0.29 ± 8.23 compared with −1.15 ± 5.25 ng/ml) compared with placebo. Adjustments for total osteocalcin and adiponectin using analysis of covariance (ANCOVA) did not affect the association of glycemic status with related variables.

Conclusions

In conclusion our study demonstrated that phylloquinone supplementation improved glycemic status in premonopausal prediabetic women independent of adiponectin.

Trial registration

This trial was registered in Iranian Registry of Clinical Trials with ID number of IRCT2013120915724N1 webcite.

【 授权许可】

   
2015 Rasekhi et al.; licensee BioMed Central.

【 参考文献 】

• [1]Shanahan CM, Proudfoot D, Farzaneh-Far A, Weissberg PL: The role of Gla proteins in vascular calcification. Critical reviews in eukaryotic gene expression 1998, 8(3–4):357-375.
• [2]Ferron M, Hinoi E, Karsenty G, Ducy P: Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A 2008, 105(13):5266-5270.
• [3]Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G: Endocrine regulation of energy metabolism by the skeleton. Cell 2007, 130(3):456-469.
• [4]Booth SL, Lichtenstein AH, O’Brien-Morse M, McKeown NM, Wood RJ, Saltzman E, Gundberg CM: Effects of a hydrogenated form of vitamin K on bone formation and resorption. Am J Clin Nutr 2001, 74(6):783-790.
• [5]Beulens JW, van der A D, Grobbee DE, Sluijs I, Spijkerman AM, van der Schouw YT: Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes. Diabetes Care 2010, 33(8):1699-1705.
• [6]Pan Y, Jackson RT: Dietary phylloquinone intakes and metabolic syndrome in US young adults. J Am Coll Nutr 2009, 28(4):369-379.
• [7]Yoshida M, Booth SL, Meigs JB, Saltzman E, Jacques PF: Phylloquinone intake, insulin sensitivity, and glycemic status in men and women. Am J Clin Nutr 2008, 88(1):210-215.
• [8]Yoshida M, Jacques PF, Meigs JB, Saltzman E, Shea MK, Gundberg C, Dawson-Hughes B, Dallal G, Booth SL: Effect of vitamin K supplementation on insulin resistance in older men and women. Diabetes Care 2008, 31(11):2092-2096.
• [9]Ibarrola-Jurado N, Salas-Salvado J, Martinez-Gonzalez MA, Bullo M: Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr 2012, 96(5):1113-1118.
• [10]Juanola-Falgarona M, Salas-Salvado J, Estruch R, Portillo MP, Casas R, Miranda J, Martinez-Gonzalez MA, Bullo M: Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk. Cardiovascular diabetology. 2013, 12:7. BioMed Central Full Text
• [11]American Diabetic Associations: Diagnosis and classification of diabetes mellitus Diab Care 2011, 34(Suppl 1):62-69.
• [12]International Physical Activity Questionnaire. IPAQ Research Committee Guidelines for the Data Processing and Analysis of the International Physical Activity Questionnaire (IPAQ)-Short and Long Forms. 2005. www.ipaq.ki.se/scoring.pdf. Accessed 10 Jun 2014
• [13]Moghaddam MHBAF, Jafarabadi MA, Allahverdipour H, Nikookheslat SD, Safarpour S: The Iranian Version of International Physical Activity Questionnaire (IPAQ) in Iran: content and construct validity, factor structure, internal consistency and stability. World Applied Sciences Journal 2012, 18(8):1073-1080.
• [14]Suh HS, Hwang IC, Lee KS, Kim KK: Relationships between serum osteocalcin, leptin and the effect of weight loss by pharmacological treatment in healthy, nonsmoking Korean obese adults. Clin Chim Acta. 2013, 418:17-21.
• [15]Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28(7):412-419.
• [16]Duncan MH, Singh BM, Wise PH, Carter G, Alaghband-Zadeh J: A simple measure of insulin resistance. Lancet 1995, 346(8967):120-121.
• [17]Knapen MH, Schurgers LJ, Shearer MJ, Newman P, Theuwissen E, Vermeer C: Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight. Br J Nutr 2012, 108(6):1017-1024.
• [18]Choi HJ, Yu J, Choi H, An JH, Kim SW, Park KS, Jang HC, Kim SY, Shin CS: Vitamin K2 supplementation improves insulin sensitivity via osteocalcin metabolism: a placebo-controlled trial. Diabetes Care 2011, 34(9):e147.
• [19]Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, Kurioka S, Yano S, Sugimoto T: Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int 2011, 22(1):187-194.
• [20]Reinehr T, Roth CL: A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss. Int J Obes (Lond) 2010, 34(5):852-858.
• [21]Abseyi N, Siklar Z, Berberoglu M, Hacihamdioglu B, Savas Erdeve S, Ocal G: Relationships between osteocalcin, glucose metabolism, and adiponectin in obese children: Is there crosstalk between bone tissue and glucose metabolism? Journal of clinical research in pediatric endocrinology 2012, 4(4):182-188.
• [22]Shea MK, Gundberg CM, Meigs JB, Dallal GE, Saltzman E, Yoshida M, Jacques PF, Booth SL: Gamma-carboxylation of osteocalcin and insulin resistance in older men and women. Am J Clin Nutr 2009, 90(5):1230-1235.
• [23]Chen X, Wu Y, Liu L, Tian H, Yu X: Osteocalcin is inversely associated with glucose levels in middle-aged Tibetan men with different degrees of glucose tolerance. Diabetes Metab Res Rev 2014, 30(6):476-482.
• [24]Hwang YC, Jeong IK, Ahn KJ, Chung HY: Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level. Osteoporos Int 2012, 23(4):1337-1342. doi: 10.1007/s00198-011-1679-x. Epub 2011 Jun 9