Innovative method using circulating tumor cells for prediction of the effects of induction therapy on locally advanced non-small cell lung cancer

Journal of Cardiothoracic Surgery

Hiroyasu Yokomise¹  Shinya Ishikawa¹  Tetsuhiko Go¹  Masaya Okuda¹  Natsumi Matsuura¹  Yoshitaka Kasai¹  Masashi Gotoh¹  Shintaro Tarumi¹ 

[1] Department of general thoracic, breast and Endocrinological surgery, Faculty of medicine Kagawa University, Kagawa, Japan

关键词: CellSearch;    Surgery;    Induction chemoradiotherapy;    Non-small cell lung cancer;    Circulating tumor cells;   

Others  :  824242
DOI  :  10.1186/1749-8090-8-175

 received in 2013-05-08, accepted in 2013-07-11,  发布年份 2013

【 摘 要 】

Background

The existence of circulating tumor cells (CTCs) in patients with lung cancer has been reported. The purpose of this study was to assess whether CTCs are predictive of the pathological effects of induction chemoradiotherapy for patients with non-small cell lung cancer.

Methods

Patients who underwent induction chemoradiotherapy followed by surgery were compared with those who underwent surgery alone. Peripheral and pulmonary venous blood samples from the involved lobe were collected intraoperatively, and the number of CTCs was counted using the CellSearch™ system, an epithelial cell adhesion molecule-based immunomagnetic technique.

Results

Of the 9 patients who underwent induction therapy, 4 achieved pathological CR, 4 achieved major response, and 1 achieved minor response. All patients who underwent induction therapy and surgery alone were negative for CTCs in peripheral blood. In the induction therapy group, 4 patients showing pathological CR were negative for CTCs in pulmonary venous blood (pvCTCs) and 5 showing major/minor response were positive (mean, 57.8 cells). The numbers of CTCs in patients showing major/minor response were significantly higher than those in patients showing pathological CR (p = 0.012, Mann–Whitney U test). All 6 patients undergoing surgery alone were positive for pvCTCs (mean, 207.5 cells), showing a significant difference from those undergoing induction therapy (p = 0.038).

Conclusions

The existence of CTCs in pulmonary venous blood reflects pathological non-CR, and therapeutic pathological response may be predicted by pvCTC measurement.

【 授权许可】

   
2013 Tarumi et al.; licensee BioMed Central Ltd.

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