Polymorphic variants of SLCO1B1 in neonatal hyperbilirubinemia in China

Italian Journal of Pediatrics

Yuyuan Luo¹  Xiaoyan Fang¹  Shaofang Zhang¹  Jun Long¹  Jiebo Liu¹ 

[1] Department of Pediatrics, The Fifth People’s Hospital of Shenzhen, No. 47 Friendship Road, Luohu District, Shenzhen, 518001, China

关键词: Organic anion transport polypeptide C;    Case-control study;    Neonatal hyperbilirubinemia;    Polymorphisms;   

Others  :  825007
DOI  :  10.1186/1824-7288-39-49

 received in 2013-05-13, accepted in 2013-08-10,  发布年份 2013

【 摘 要 】

Background

To evaluate the association between the genetic polymorphism of the solute carrier organic anion transporter family member 1B1 (SLCO1B1, also known as organic anion transport polypeptide C) and hyperbilirubinemia in Chinese neonates.

Methods

183 infants with hyperbilirubinemia and 192 control subjects from the Fifth People’s Hospital of Shenzhen were recruited. Polymerase chain reaction, restriction fragment length polymorphisms and agarose gel electrophoresis techniques were used to detect genetic variants of SLCO1B1.

Results

The study revealed that SLCO1B1 388 G > A occurred significantly more frequently in neonates with hyperbilirubinemia than in controls (RR = 1.50; 95% CI: 1.13–2.00). There were no significant differences in SLCO1B1 521 T > C between the hyperbilirubinemia and the control group (RR, 1.00; 95% CI, 0.72–1.40). No carriage of the C to A substitution at nucleotide 463 was detected.

Conclusion

The SLCO1B1 388 G > A variant is associated with neonatal hyperbilirubinemia in Chinese neonates.

【 授权许可】

   
2013 Liu et al.; licensee BioMed Central Ltd.

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