Low HDL cholesterol is correlated to the acute ischemic stroke with diabetes mellitus

Lipids in Health and Disease

Yun Xu²  Junfeng Zhang¹  Jingwei Li²  Yun Luo¹ 

[1] School of Life Science, Nanjing University, Nanjing 210093, China;Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

关键词: High density lipoprotein cholesterol;    Ischemic stroke;    Diabetes mellitus;   

Others  :  1145606
DOI  :  10.1186/1476-511X-13-171

 received in 2014-08-22, accepted in 2014-10-21,  发布年份 2014

【 摘 要 】

Background

To clarify the role of lipid composition in the occurrence of acute ischemic stroke (AIS) with diabetes mellitus (DM) and its influence factors.

Methods

Data was collected from the patients hospitalization in Affiliated Drum Tower Hospital of Nanjing University Medical School from October 2008 to May 2012, which included AIS and non-AIS consist of transient ischemic attack (TIA) and Vertigo or dizzy. Lipid and other risk factors including blood glucose (BG), uric acid (UA), hypertension, DM and atrial fibrillation (AF) were investigated in relation to occurrence of AIS.

Results

The level of high density lipoprotein (HDL) cholesterol was decreased obviously in the DM group compared to the non-DM group and low level of HDL cholesterol was prevalent in the AIS patients with DM. logistic regression demonstrated that decreased HDL cholesterol was correlated to the AIS with DM, not all AIS, and the relative risk of ischemic stroke in low HDL cholesterol level group was 2.113 (95% CI = 1.191-3.749, P = 0.011) compared to the high level group. Furthermore, age has the obviously impact on it. HDL cholesterol was correlated to the AIS with DM just in the populations of aged ≦70 years (OR = 0.192, P = 0.000), low level of HDL cholesterol had more high risk of ischemic stroke than that in the high level group (OR = 6.818, P = 0.002).

Conclusion

Decreased HDL cholesterol was correlated to the occurrence of AIS with DM, especially in the populations of aged ≦70 years.

【 授权许可】

   
2014 Luo et al.; licensee BioMed Central Ltd.

【 图 表 】

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