A rare case of intravascular epithelioid hemangioendothelioma of the cephalic vein treated with surgery and postoperative radiation therapy: a case report and review of the literature

Journal of Medical Case Reports

Marco Lioce¹  Gabriele Matichecchia¹  Antonio Pascali¹  Raffaella Caponio¹  Maria Paola Ciliberti¹ 

[1] U.O. Radioterapia - National Cancer Research Centre - Istituto Tumori “Giovanni Paolo II”, viale Orazio Flacco, Bari, 65-70124, Italy

关键词: Review;    Cephalic vein;    Radiotherapy;    Intravascular;    Vascular;    Epithelioid hemangioendothelioma;   

Others  :  1204626
DOI  :  10.1186/s13256-015-0565-0

 received in 2014-10-26, accepted in 2015-03-04,  发布年份 2015

【 摘 要 】

Introduction

Epithelioid hemangioendothelioma (EHE) is a rare endothelial tumor with an intermediate grade of malignancy. Few cases of primary vascular hemangioendothelioma have been described in the literature. Surgery is the treatment of choice, but radiation therapy and chemotherapy should also be considered in particular cases.

Case presentation

We present the case of a 44-year-old Caucasian woman affected by EHE of the cephalic vein, treated by complete surgical removal of the mass and postoperative local radiation therapy. At 5-year follow-up, our patient is alive, with no signs of local or distant relapse and with no late radiation-related effects.

Conclusions

Postoperative radiotherapy may play a role in cases in which tumor margins are close or cannot be assessed or when high-risk features are present.

【 授权许可】

   
2015 Ciliberti et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F. World Health Organization Classification of tumours of soft tissue and bone. 4th ed. IARC Press, Lyon; 2013.
• [2]Trombetta D, Magnusson L, von Steyern FV, Hornick JL, Fletcher CD, Mertens F. Translocation t(7;19)(q22;q13) – a recurrent chromosome aberration in pseudomyogenic hemangioendothelioma? Cancer Genet. 2011; 204:211-5.
• [3]Requena L, Kutzner H. Hemangioendothelioma. Semin Diagn Pathol. 2013; 30:29-44.
• [4]Fernández Y, Bernabeu-Wittel M, García-Morillo JS. Kaposiform hemangioendothelioma. Eur J Intern Med. 2009; 20:106-13.
• [5]Zhang G, Qianjin L, Yin H, Wen H, Yuwen S, Li D et al.. A case of retiform-hemangioendothelioma with unusual presentation and aggressive clinical features. Int J Clin Exp Pathol. 2010; 3:528-33.
• [6]Calonje E, Fletcher CD, Wilson-Jones E, Rosai J. Retiform hemangioendothelioma. A distinctive form of low-grade angiosarcoma delineated in a series of 15 cases. Am J Surg Pathol. 1994; 18:115-25.
• [7]McNab PM, Quigley BC, Glass LF, Jukic DM. Composite hemangioendothelioma and its classification as a low-grade malignancy. Am J Dermatopathol. 2013; 35:517-22.
• [8]Deyrup AT, Tighiouart M, Montag AG, Weiss SW. Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol. 2008; 32:924-7.
• [9]Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 1982; 50:970-81.
• [10]Makhlouf HR, Ishak KG, Goodman ZD. Epithelioid hemangioendothelioma of the liver: a clinicopathologic study of 137 cases. Cancer. 1999; 85:562-82.
• [11]Evans HL, Raymond AK, Ayala AG. Vascular tumors of bone: a study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid hemangioendothelioma, and high-grade angiosarcoma. Hum Pathol. 2003; 34:680-9.
• [12]Christodoulou A, Symeonidis PD, Kapoutsis D, Iordanidis F. Primary epithelioid hemangioendothelioma of the lumbar spine. Spine J. 2008; 8:385-90.
• [13]Corrin B, Manners B, Millard M, Weaver L. Histogenesis of the so-called “intravascular bronchioloalveolar tumour”. J Pathol. 1979; 128:163-7.
• [14]de Albuquerque AKA C, de Oliveira Romano S, Eisenberg ALA. Epithelioid hemangioendothelioma: 15 years at the National Cancer Institute. Literature review. J Bras Patol Med Lab. 2013; 49:119-25.
• [15]Weissferdt A, Moran C. Primary vascular tumors of the lungs: a review. Ann Diagn Pathol. 2010; 14:296e308.
• [16]Gill R, O’Donnell RJ, Horvai A. Utility of immunohistochemistry for endothelial markers in distinguishing epithelioid hemangioendothelioma from carcinoma metastatic to bone. Arch Pathol Lab Med. 2009; 133:967-72.
• [17]Fujii T, Zen Y, Sato Y, Sasaki M, Enomae M, Minato H et al.. Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. Mod Pathol. 2008; 21:125-30.
• [18]Naqvi J, Ordonez NG, Luna MA, Williams MD, Weber RS, El-Naggar AK. Epithelioid hemangioendothelioma of the head and neck: role of podoplanin in the differential diagnosis. Head Neck Pathol. 2008; 2:25-30.
• [19]Kösemehmetoğlu K, Gedikoğlu G, Ruacan S. Morphological and immunohistochemical features of malignant vascular tumors with special emphasis on GlUT1, and FkBP12 expressions. Turkish J Pathology. 2011; 27:57-67.
• [20]Higgins JP, Montgomery K, Wang L, Domanay E, Warnke RA, Brooks JD et al.. Expression of FKBP12 in benign and malignant vascular endothelium: an immunohistochemical study on conventional sections and tissue microarrays. Am J Surg Pathol. 2003; 27:58-64.
• [21]Mendlick MR, Nelson M, Pickering D, Johansson SL, Seemayer TA, Neff JR et al.. Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma. Am J Surg Pathol. 2001; 25:684-68.
• [22]Errani C, Zhang L, Shao SY, Hajdu M, Singer S, Maki RG et al.. A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosomes Cancer. 2011; 50:644-53.
• [23]Antonescu CR, Le Loarer F, Mosquera JM, Sboner A, Zhang L, Chen CL et al.. Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma. Genes Chromosomes Cancer. 2013; 52:775-84.
• [24]Osawa S, Saito A, Shimizu H, Ogawa T, Watanabe M, Tominaga T. A case of intravascular epithelioid hemangioendothelioma occurring 14 years after coil embolization for an extracranial internal carotid artery aneurysm. J Vasc Surg. 2012; 55:230-3.
• [25]Mentzel T, Beham A, Calonje E, Katenkamp D, Fletcher CD. Epithelioid hemangioendothelioma of skin and soft tissues: clinicopathologic and immunohistochemical study of 30 cases. Am J Surg Pathol. 1997; 21:363-74.
• [26]Palsson B. Epitheloid hemangioendothelioma. Acta Oncol. 1999; 38:659-61.
• [27]Castelli P, Caronno R, Piffaretti G, Tozzi M. Epithelioid hemangioendothelioma of the radial artery. J Vasc Surg. 2005; 41:151-4.
• [28]Harris EJ, Taylor LM, Porter JM. Epithelioid hemangioendothelioma of the external iliac vein: a primary vascular tumor presenting as traumatic venous obstruction. J Vasc Surg. 1989; 10:693-9.
• [29]Ravi V, Patel S. Vascular sarcomas. Curr Oncol Rep. 2013; 15:347-55.
• [30]Treglia G, Ceriani L, Paone G, Rusca T, Bongiovanni M, Giovanella L. Multifocal epithelioid hemangioendothelioma of the lower limbs detected by 18F-FDG PET/MRI. Clin Nucl Med. 2015; 40:352-4.
• [31]Kerrya G, Marxa O, Krausb D, Vogelc M, Kaiserd A, Ruedingera C et al.. Multifocal epithelioid hemangioendothelioma derived from the spine region: case report and literature review. Case Rep Oncol. 2012; 5:91-8.
• [32]Tsuneyoshi M, Dorfman HD, Bauer TW. Epithelioid hemangioendothelioma of bone. Am J Surg Pathol. 1986; 10:754-64.
• [33]Mehrabi A, Kashfi A, Fonouni H, Schemmer P, Schmied BM, Hallscheidt P et al.. Primary malignant hepatic epithelioid hemangioendothelioma: a comprehensive review of the literature with emphasis on the surgical therapy. Cancer. 2006; 107:2108-21.
• [34]Jinghong X, Lirong C. Pulmonary epithelioid hemangioendothelioma accompanied by bilateral multiple calcified nodules in lung. Diagn Pathol. 2011; 6:21.
• [35]Jang KY, Jin GY, Lee YC, Lee HB, Kang MJ, Choi HY et al.. Pulmonary epithelioid hemangioendothelioma: a tumor presented as a single cavitary mass. J Korean Med Sci. 2003; 18:599-602.
• [36]Resnik KS, Kantor GR, Spielvogel RL, Ryan E. Cutaneous epithelioid hemangioendothelioma without systemic involvement. Am J Dermatopathol. 1993; 15:272-6.
• [37]Quante M, Patel NK, Hill S, Merchant W, Courtauld E, Newman P et al.. Epithelioid hemangioendothelioma presenting in the skin: a clinicopathologic study of eight cases. Am J Dermatopathol. 1998; 20:541-6.
• [38]Nora FE, Scheithauer BW. Primary epithelioid hemangioendothelioma of the brain. Am J Surg Pathol. 1996; 20:707-14.
• [39]Baehring JM, Dickey PS, Bannykh SI. Epithelioid hemangioendothelioma of the suprasellar area: a case report and review of the literature. Arch Pathol Lab Med. 2004; 128:1289-93.
• [40]Zheng J, Liu L, Wang J, Wang S, Cao Y, Zhao J. Primary intracranial epithelioid hemangioendothelioma: a low-proliferation tumor exhibiting clinically malignant behavior. J Neurooncol. 2012; 110:119-27.
• [41]Zheng J, Li P, Ma S, Geng M. Epithelioid hemangioendothelioma of the meninges mimicking metastatic carcinoma: a case report. Clin Neuropathol. 2013; 32:324-7.
• [42]Robinson AA, Tolentino LF, Uyanne J, Melrose R, Calhoun CC. Malignant epithelioid hemangioendothelioma of the lip: a case report and comprehensive literature review. J Oral Maxillofac Surg. 2014; 72:695-701.
• [43]Gordón-Núñez MA, Silva LM, Lopes MF, de Oliveira-Neto SF, Maia AP, Galvão HC. Intraoral epithelioid hemangioendothelioma: a case report and review of the literature. Med Oral Patol Oral Cir Bucal. 2010; 15:e340-6.
• [44]Wesley RK, Mintz SM, Wertheimer FW. Primary malignant hemangioendothelioma of the gingiva. Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol. 1975; 39:103-12.
• [45]Panda NK, Rao SS, Karuppiah S, Vaiphei K, Singh P. Epithelioid hemangioendothelioma of middle ear masquerading as glomus tumor. Am J Otolaryngol. 2007; 28:69-71.
• [46]Krisch K, Holzner JH, Kokoschka R, Jakesz R, Niederle B, Roka R. Hemangioendothelioma of the thyroid gland–true endothelioma or anaplastic carcinoma? Pathol Res Pract. 1980; 170:230-42.
• [47]Yoruk O, Erdem H, Mutlu V, Erdogan F, Altas E, Kantarci M. Epithelioid hemangioendothelioma of the submandibular gland. Auris Nasus Larynx. 2008; 35:157-9.
• [48]Drazin D, Gandhi R, Slodkowska E, Boulos AS. Epithelioid hemangioendothelioma of the mastoid: resection for recurrence and adjuvant radiation with 8-year followup. Case Rep Surg. 2013 (2013):469201, PMC. Web. 18 Mar. 2015 (Online publication only).
• [49]Semino L, Pagella F, Delù G, Todeschini A, Luinetti O, Zappoli F et al.. Endoscopic treatment of ethmoidal hemangioendothelioma: case report and review of the literature. Am J Otolaryngol. 2006; 27:287-90.
• [50]Park SY, Lee JK, Jo S, Huh CH, Cho KH, Na JI. Cutaneous epithelioid hemangioendothelioma presented as an ulcerated areolar mass. J Dermatol. 2014; 41:112-3.
• [51]Márquez-Medina D, Samamé-Pérezvargas JC, Tuset-DerAbrain N, Montero-Fernández A, Taberner-Bonastre T, Porcel JM. Pleural epithelioid hemangioendothelioma in an elderly patient. A case report and review of the literature. Lung Cancer. 2011; 73:116-9.
• [52]Lee YJ, Chung MJ, Jeong KC, Hahn CH, Hong KP, Kim YJ et al.. Pleural epithelioid hemangioendothelioma. Yonsei Med J. 2008; 49:1036-40.
• [53]Lazarus A, Fuhrer G, Malekiani C, McKay S, Thurber J. Primary pleural epithelioid hemangioendothelioma (EHE) – two cases and review of the literature. Clin Respir J. 2011; 5(1):e1-5.
• [54]Donato G, Conforti F, Allegra E. A rare case of primary nodal hemangioendothelioma. Oncol Lett. 2013; 6:1759-61.
• [55]Mansour Z, Neuville A, Massard G. Mediastinal epithelioid haemangioendothelioma: a rare mediastinal tumour. Interact Cardiovasc Thorac Surg. 2010; 10:122-4.
• [56]Blanco M, Gil P, Jove P. Hemangioendotelioma epitelioide mediastínico simulando un teratoma. Arch Bronconeumol. 2011; 47:376-7.
• [57]Moulai N, Chavanon O, Guillou L, Noirclerc M, Blin D, Brambilla E et al.. Atypical primary epithelioid hemangioendothelioma of the heart. J Thorac Oncol. 2006; 1:188-9.
• [58]Messias P, Bernardo J, Antunes MJ. Primary left atrial haemangioendothelioma. Interact Cardiovasc Thorac Surg. 2008; 7:945-6.
• [59]Safirstein J, Aksenov S, Smith F. Cardiac epithelioid hemangioendothelioma with 8-year follow-up. Cardiovasc Pathol. 2007; 16:183-6.
• [60]Lisy M, Beierlein W, Müller H, Bültmann B, Ziemer G. Left atrial epithelioid hemangioendothelioma. J Thorac Cardiovasc Surg. 2007; 133:803-4.
• [61]Marchiano D, Fisher F, Hofstetter S. Epithelioid hemangioendothelioma of the heart with distant metastases. A case report and literature review. J. Cardiovasc Surg (Torino). 1993; 34:529-33.
• [62]Iimuro Y, Nakai N, Asano Y, Uyama N, Suzumura K, Nakai M et al.. Primary epithelioid hemangioendothelioma of the retroperitoneum: report of a case. Surg Today. 2012; 42:1026-31.
• [63]Akosa AB, Ali MH. Epithelioid hemangioendothelioma of terminal ileum after therapeutic irradiation. J Clin Pathol. 1989; 42:889-90.
• [64]Li H, Shah D, Shah A, Qiu X, Cao D. Ileal malignant hemangioendothelioma as a hypervascular lesion on computed tomography scan. Int J Surg Case Rep. 2014; 5:19-21.
• [65]Yasuda S, Hashimoto T, Kanaizumi T, Kuwata H, Matsumoto I, Shiratori T. A case of hemangioendothelioma of the small intestine. Jpn J Surg. 1989; 19:67-9.
• [66]Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru V. Rare diffuse peritoneal malignant neoplasms: CT findings in two cases. Abdom Imaging. 2003; 28:827-30.
• [67]Tsolos C, Polychronidis A, Sivridis E, Kelidis G, Simopoulos C. Epithelioid hemangioendothelioma of the testis. J Urol. 2001; 166:1834.
• [68]Geramizadeh B, Banani A, Foroutan H, Aminsharifi A, Karimi M. Malignant epithelioid hemangioendothelioma of the bladder: the first case report in a child. J Pediatr Surg. 2009; 44:1443-5.
• [69]Jain D, Sharma MC, Epari S, Gupta NP, Kolla SB. Hemangioendothelioma of urinary bladder - report of rare case. Urology. 2009; 73:1259-61.
• [70]Gharajeh A, Siemens DR, Isotalo PA, Nascimento AG, Borth CS. Multifocal penile epithelioid hemangioendothelioma masquerading as superficial penile vein thrombosis. Urology. 2006; 68:673.
• [71]da Silva BB, Lopes-Costa PV, Furtado-Veloso AM, Borges RS. Vulvar epithelioid hemangioendothelioma. Gynecol Oncol. 2007; 105:539-41.
• [72]Haap M, Kötter I, Horger M, Thamer C, Wehrmann M, Häring HU et al.. Disseminated epitheloid hemangioendothelioma mimicking symptoms of systemic vasculitis. Onkologie. 2005; 28:429-32.
• [73]Minyi Y, Xintian H, Weimin L, Mier J. Intravascular epithelioid hemangioendothelioma. Int Angiol. 2011; 30:181-4.
• [74]Reix T, Sevestre H, Sevestri-Pietri MA, Szychta P, Pietri J. Primary malignant tumors of the venous system in the lower extremities. Ann Vasc Surg. 1998; 12:589-96.
• [75]Louail B, Vautier-Rodary R, Gondry-Jouet C, Westeel A, Filloux-Morfaux V, Auquier M et al.. Value of imaging in early diagnosis of peripheral vein tumors. J Radiol. 1998; 79:1387-91.
• [76]Shijubo N, Nakata H, Sugaya F, Imada A, Suzuki A, Kudoh K et al.. Malignant hemangioendothelioma of the aorta. Intern Med. 1995; 34:1126-9.
• [77]Traverse JH, Lesser JR, Flygenring BP, Bracken TH, Olevsky OM, Nicoloff DM et al.. Epithelioid hemangioendothelioma of the thoracic aorta resulting in aortic obstruction and congestive heart failure. Circulation. 1999; 100:564-5.
• [78]Delin A, Johansson G, Silfverswärd C. Vascular tumours in occlusive disease of the iliac-femoral vessels. Eur J Vasc Surg. 1990; 4:539-42.
• [79]Gundara JS, Gill AJ, Neale M, Collins PJ, Hugh TJ, Samra JS. Inferior vena cava epithelioid hemangioendothelioma. J Vasc Surg. 2013; 1:75-7.
• [80]Henriquez CR, Cazes A, Fabiani JN, Bruneval P. Epithelioid hemangioendothelioma of the inferior vena cava. Ann Pathol. 2011; 31:218-21.
• [81]Scordi-Bello IA, Snyder A, Schwartz M, Fallon JT. Intravascular epithelioid hemangioendothelioma of the inferior vena cava: case report of an unusual and unpredictable vascular tumor. Cardiovasc Pathol. 2009; 18:243-6.
• [82]Lahon B, Fabre D, De Montpreville V, Dartevelle P. Epithelioid haemangioendothelioma of the superior vena cava. Interact Cardiovasc Thorac Surg. 2012; 15:186-7.
• [83]Namaoui RY, Marcheix B, Zohra MF, Bonnet V, Delisle MB, Gomez-Brouchet A. An exceptional tumor of the vena cava. Ann Pathol. 2011; 31:406-8.
• [84]Ferretti GR, Chilles C, Woodruff RD, Choplin RH. Epithelioid hemangioendothelioma of the superior vena cava: computed tomography demonstration and review of the literature. J Thorac Imaging. 1998; 13:45-8.
• [85]Yousem SA, Hochholzer L. Unusual thoracic manifestations of epithelioid hemangioendothelioma. Arch Pathol Lab Med. 1987; 111:459-63.
• [86]de Verbizier G, Gasquet C, Barret D, Drouineau J, Poncin E, Touchard G et al.. Epithelioid hemangioendothelioma of the liver and superior vena cava. Radiological results apropos of a case in an adult. J Radiol. 1987; 68:55-9.
• [87]Li XM, Lin XY, Xu HT, Yu JH, Wang L, Fan CF et al.. Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma. Diagn Pathol. 2013; 8:103.
• [88]Isowa N, Hasegawa S, Mino M, Morimoto K, Wada H. Mediastinal epithelioid hemangioendothelioma resected by hemi-plastron window technique. Ann Thorac Surg. 2002; 74:567-9.
• [89]Moreno A, Asunción Cañadas M, Minguella J, Torras J. Histiocytoid hemangioma of the innominate vein. Pathol Res Pract. 1988; 183:785-91.
• [90]Toursarkissian B, O’Connor WN, Dillon ML. Mediastinal epithelioid hemangioendothelioma. Ann Thorac Surg. 1990; 49:680-5.
• [91]Nataf P, Regnard JF, Solvignon F, Bruneval P, Faucher JN, Levasseur P. Epithelioid hemangioendothelioma of the azygos vein. Arch Mal Coeur Vaiss. 1989; 82:1919-22.
• [92]De Palma A, Pagliarulo V, Ardò N, Loizzi D. Surgical treatment of a rare case of epithelioid hemangioendothelioma of the azygos vein. Interact Cardiovasc Thorac Surg. 2012; 14:91-3.
• [93]Lamovec J, Sobel HJ, Zidar A, Jerman J. Epithelioid hemangioendothelioma of the anterior mediastinum with osteoclast-like giant cells. Light microscopic, immunohistochemical, and electron microscopic study. Am J Clin Pathol. 1990; 93:813-7.
• [94]Jain A, Fulton JJ. A rare vascular tumor presenting as persistent pain at the site of a chronic DVT. J Vasc Surg. 2011; 54(6):1861.
• [95]Charette S, Nehler MR, Whitehill TA, Gibbs P, Foulk D, Krupski WC. Epithelioid hemangioendothelioma of the common femoral vein: case report and review of the literature. J Vasc Surg. 2001; 33:1100-3.
• [96]Mlynski J, Domont A, Mallios S, Bonvalot S. Fukui. Epithelioid hemangioendothelioma of the femoral vein in a 22-year-old female. EJVES Extra. 2013; 25:e1-2.
• [97]Kugai T. Epithelioid hemangioendothelioma of the remnant femoral vein associated with a persistent sciatic vein. Jpn J Vasc Surg. 2006; 15:387-90.
• [98]Schröder A, Peters A, Riepe G, Larena A, Meierling S, Mentzel T et al.. Vascular tumors simulating occlusive disease. Vasa. 2001; 30:62-6.
• [99]Aydin H, Koçer B, Erekul S, Sakinci U. Epithelioid hemangioendothelioma on left femoral artery after multiple femoral artery interventions. EJVES Extra. 2006; 11:112-4.
• [100]Muñoz A, Diaz-Perez JA, Romero-Rojas AE, Hernandez E, Martin-Berdazco F. Report of 2 cases of primary epithelioid hemangioendothelioma of the external iliac vein. Vasc Endovascular Surg. 2013; 47:474-8.
• [101]Ludwikowski B, Jones N. Epithelioid hemangioendothelioma of external iliac vein with multiple metachronous localisations in liver and lung. Abstract book of the 9th International Danube Symposuium of Pediatric Surgery; 2005 20-22 Oct; Vienna, Austria. Available on http://www.kidsdoc.at/va_donausymposium_abstracts.html.
• [102]Deedar-Ali-Khawaja R, Fatimi SH, Shahabuddin S. Epithelioid hemangioendothelioma of axillary vein: an imminent vascular tumor? Am Surg. 2010; 76:e176-7.
• [103]Zingale A, Bruno G, Giuffrè F, Carpinteri M, Albanese V. Hemangioendothelioma mimicking a median nerve neoplasm. Case report. J Neurosurg Sci. 1993; 37:119-22.
• [104]Akashi K, Yasuda M, Suto R, Fukuda H, Itoh J, Tsutsumi Y et al.. A case of epithelioid hemangioendothelioma associated with an artery. Tokai J Exp Clin Med. 1997; 22:65-9.
• [105]Henton JM, Kang N. Epithelioid hemangioendothelioma: occasionally encountered and potentially harmful. J Plast Reconstr Aesthet Surg. 2013; 66:131-3.
• [106]Zhang J, Wang Y, He X, Lu N, Xu D. Epithelioid hemangioendothelioma adjacent to the axilla: a case report. Chin Ger J Clin Oncol. 2010; 9:359-61.
• [107]Nuthakki S, Fessell D, Lal N, Shirkhoda A, Irwin T, Irwin R. Epithelioid hemangioendothelioma mimicking a nerve sheath tumor clinically and on MR imaging. Skeletal Radiol. 2007; 36 Suppl 1:S58-62.
• [108]Heldenberg E, Rabin I, Cheyn D, Lorber J, Elkabetz E, Sandbank J et al.. Epithelioid hemangioendothelioma as a rare cause of blue toe syndrome. J Vasc Surg. 2011; 54:854-6.
• [109]Wu XN, Chen MJ, Li DQ, Hu JG, Yu FL. Pulmonary artery pseudoaneurysm caused by a rare vascular tumor: epithelioid hemangioendothelioma. Thorac Cardiovasc Surg. 2014; 62:92-4.
• [110]Tayeb T, Bouzaiene M. Epithelioid hemangioendothelioma mimicking an occipital artery aneurysm. Rev Stomatol Chir Maxillofac. 2007; 108:451-4.
• [111]El Demellawy D, Nasr A, Alowami S. Epithelioid hemangioendothelioma of the temporal artery presenting as temporal arteritis: case report and literature review. Rare Tumors. 2009; 1:e20.
• [112]Koh YC, Yoo H. Epithelioid haemangioendothelioma of the sphenoid bone. J Clin Neurosci. 2001; Suppl 1:63-6.
• [113]Hampers DA, Tomaino MM. Malignant epithelioid hemangioendothelioma presenting as an aneurysm of the superficial palmar arch: a case report. J Hand Surg Am. 2002; 27:670-3.
• [114]Cronin P, Arenberg D. Pulmonary epithelioid hemangioendothelioma: an unusual case and a review of the literature. Chest. 2004; 125:789-93.
• [115]Bouslama K, Houissa F, Rejeb MB, Bouzaidi S, Moualhi L, Mekki H et al.. Malignant epithelioid hemangioendothelioma: a case report. Oman Med J. 2013; 28:135-7.
• [116]Akça S, Süleymanlar I, Dinçer D, Demirbaş A, Gelen T, Gürkan A et al.. Hepatic epithelioid hemangioendothelioma treated with orthotopic liver transplantation: a case report. Turk J Gastroenterol. 2002; 13:221-5.
• [117]Samuel M, Spitz L. Infantile hepatic hemangioendothelioma: the role of surgery. J Pediatr Surg. 1995; 30:1425-9.
• [118]Aflatoon K, Staals E, Bertoni F, Bacchini P, Donati D, Fabbri N et al.. Hemangioendothelioma of the spine. Clin Orthop Relat Res. 2004; 418:191-7.
• [119]Soloman R, Gabizon AA. Clinical pharmacology of liposomal anthracyclines: focus on pegylated liposomal doxorubicin. Clin Lymphoma Myeloma. 2008; 8:21-32.
• [120]Grenader T, Vernea F, Reinus C, Gabizon A. Malignant epithelioid hemangioendothelioma of the liver successfully treated with pegylated liposomal doxorubicin. J Clin Oncol. 2011; 29:e722-4.
• [121]Niemelä M, Mäenpää H, Salven P, Summanen P, Poussa K, Laatikainen L, Jääskeläinen J, Joensuu H. Interferon alpha-2a therapy in 18 hemangioblastomas. Clinical Cancer Res. 2001; 7:510-6.
• [122]Palmieri G, Montella L, Martignetti A, Bianco AR. Interferon α-2b at low doses as long-term antiangiogenic treatment of a metastatic intracranial hemangioendothelioma: a case report. Oncol Rep. 2000; 7:145-9.
• [123]Calabrò L, Di Giacomo AM, Altomonte M, Fonsatti E, Mazzei MA, Volterrani L et al.. Primary hepatic epithelioid hemangioendothelioma progressively responsive to interferon-alpha: is there room for novel anti-angiogenetic treatments? J Exp Clin Cancer Res. 2007; 26:145-50.
• [124]Gaur S, Torabi A, O’Neill TJ. Activity of angiogenesis inhibitors in metastatic epithelioid hemangioendothelioma: a case report. Cancer Biol Med. 2012; 9:133-6.
• [125]Agulnik M, Yarber JL, Okuno SH, von Mehren M, Jovanovic BD, Brockstein BE et al.. An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas. Ann Oncol. 2013; 24:257-63.
• [126]Raphael C, Hudson E, Williams L, Lester JF, Savage PM. Successful treatment of metastatic hepatic epithelioid hemangioendothelioma with thalidomide: a case report. J Med Case Rep. 2010; 4:413.
• [127]Mascarenhas RC, Sanghvi AN, Friedlander L, Geyer SJ, Beasley HS, Van Thiel DH. Thalidomide inhibits the growth and progression of hepatic epithelioid hemangioendothelioma. Oncology. 2004; 67:471-5.
• [128]Sumrall A, Fredericks R, Berthold A, Shumaker G. Lenalidomide stops progression of multifocal epithelioid hemangioendothelioma including intracranial disease. J Neurooncol. 2010; 97:275-7.
• [129]Ye B, Li W, Feng J, Shi JX, Chen Y, Han BH. Treatment of pulmonary epithelioid hemangioendothelioma with combination chemotherapy: report of three cases and review of the literature. Oncol Lett. 2013; 5:1491-6.
• [130]Chevreau C, Le Cesne A, Ray-Coquard I, Italiano A, Cioffi A, Isambert N et al.. Sorafenib in patients with progressive epithelioid hemangioendothelioma: a phase 2 study by the French Sarcoma Group (GSF/GETO). Cancer. 2013; 119:2639-44.
• [131]Laçın S, Küçük O, Oz I, Bılgıç S. Selective intra-arterial Y-90 microsphere therapy in hemangioendothelioma. Turk J Gastroenterol. 2011; 22:89-92.
• [132]Biswal BM, Rath GK, Sandhu M, Rastogi S. Radiotherapy in symptomatic skeletal hemangiomas. Indian J Radiol Imaging. 1995; 5:157e159.
• [133]Brennan J, Midha R, Ang L, Perez-Ordonez B. Epithelioid hemangioendothelioma of the spine presenting as cervical myelopathy: case report. Neurosurgery. 2001; 48:1166-9.
• [134]Scott M, Indelicato DJ, Morris CG, Gibbs C, Scarborough MT, Reith JD et al.. Radiotherapy for hemangioendothelioma: the University of Florida experience. Int J Radiat Oncol Biol Phys. 2011; 81:S634-5.
• [135]Yin KL, Sumathi VP, Spooner D. Radiotherapy as an effective primary treatment for epithelioid hemangioendothelioma of the cervical spine. Anticancer Res. 2012; 32:4597-600.
• [136]Gherman CD, Fodor D. Epithelioid hemangioendothelioma of the forearm with radius involvement. Case report. Diagn Pathol. 2011; 6:120.
• [137]Watanabe T, Saito N, Shimaguchi H, Fujimaki H, Kamiya M, Nakazato Y et al.. Primary epithelioid hemangioendothelioma originating in the lower petroclival region: case report. Surg Neurol. 2003; 59:429-33.
• [138]Themistocleus GS, Papagelopoulos PJ, Petraki KD, Stilianessi EV, Partsnevelos AA, Sapkas GS. A 23-year-old woman with complete paraplegia and anesthesia below the T8 level. Clin Orthop Relat Res. 2005; 430:258-65.
• [139]Kleer CG, Unni KK, McLeod RA. Epithelioid hemangioendothelioma of bone. Am J Surg Pathol. 1996; 20:1301-11.
• [140]Wold LE, Unni KK, Beabout JW, Ivins JC, Bruckman JE, Dahlin DC. Hemangioendothelial sarcoma of bone. Am J Surg Pathol. 1982; 6:59-70.