T helper cell mediated-tolerance towards fetal allograft in successful pregnancy

Clinical and Molecular Allergy

Philippe Le Bouteiller¹  Sergio Romagnani²  Ornela Kullolli²  Federica Logiodice²  Letizia Lombardelli²  Marie-Pierre Piccinni² 

[1] INSERM UMR1043, CNRS UMR5282, Université de Toulouse III, Centre de Physiopathologie Toulouse-Purpan, Toulouse 31024, France;Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, Florence 50134, Italy

关键词: Allograft;    Abortion;    Pregnancy;    Th17;    Th2;    Th1;    T helper cells;   

Others  :  1212277
DOI  :  10.1186/s12948-015-0015-y

 received in 2015-01-30, accepted in 2015-03-16,  发布年份 2015

【 摘 要 】

Trophoblast HLA-C antigens from paternal origins, which liken the trophoblast to a semiallograft, could be presented by the maternal APCs to the specific maternal CD4+ T helper cells, which could release various cytokines in response to these alloantigens. On the basis of the cytokines produced, these cells can be classified in Th1, Th2 and Th17 cells. Th1 and Th17 cells, known to be responsible for acute allograft rejection, could be involved in miscarriage and Th2 cells together with regulatory CD4+ T cells, known to be involved in allograft tolerance, could be responsible, at least in part, for the success of pregnancy. In this review we focus the role effector CD4+ T cells Th1, Th2 and Th17 cells on the fetal allograft tolerance.

【 授权许可】

   
2015 Piccinni et al.; licensee BioMed.

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