An unusual case of giant cell myocarditis missed in a Heartmate-2 left ventricle apical-wedge section: a case report and review of the literature

Journal of Cardiothoracic Surgery

Anique Ducharme²  Michel White²  Normand Racine²  Mark Liszkowski²  Guy B Pelletier²  Philippe Romeo¹  Michel Carrier³  Kim Anderson² 

[1] Department of Pathology, Montreal Heart Institute, University of Montreal, 5000, Belanger East, Montreal, QC, H1T 1C8, Canada;Department of Medicine, Montreal Heart Institute, University of Montreal, 5000, Belanger East, Montreal, QC, H1T 1C8, Canada;Department of Cardiac Surgery, Montreal Heart Institute, University of Montreal, 5000, Belanger East, Montreal, QC, H1T 1C8, Canada

关键词: Left ventricular assist device;    Endomyocardial biopsy;    Heart transplant;    Immunosuppression;    Lymphoma;    Lymphocytic myocarditis;    Giant cell myocarditis;   

Others  :  829456
DOI  :  10.1186/1749-8090-8-12

 received in 2012-09-19, accepted in 2013-01-11,  发布年份 2013

【 摘 要 】

Herein we present a case of fulminant myocarditis in a woman previously treated for B-cell lymphoma. While the clinical context was suggestive of adriamycin-induced cardiomyopathy, the initial pathology of the Heartmate-2 apical core showed lymphocytic myocarditis. After 8 months of stability, the patient presented with progressive heart failure and recurrent ventricular arrhythmias. An endomyocardial biopsy revealed findings typical of giant cell myocarditis (GCM); poor response to immunosuppressive therapy and marked hemodynamic instability led to urgent transplantation. To our knowledge, this is the first reported case of GCM following an acute lymphocytic myocarditis and the second GCM case associated with B-cell lymphoma.

【 授权许可】

   
2013 Anderson et al.; licensee BioMed Central Ltd.

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