Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice

Journal of Translational Medicine

Vincent Minville²  Jean-Pierre Girolami²  Bernard Francès⁴  Ivan Tack²  Olivier Fourcade¹  Lionel Mouledous⁵  Nelly Blaes²  Anne Gomez-Brouchet³ 

[1] Department of Anaesthesiology and Intensive Care, Toulouse University Hospital, Toulouse, 31432, France;Institute of Metabolic and Cardiovascular Diseases, I2MC, INSERM, U1048, Université Paul Sabatier, Toulouse, 31432, France;Service d’Anatomie Pathologique et Histologie-Cytologie, IUCT Oncopôle, 1 Avenue du Juliot Curie, Toulouse Cedex 9, 31059, France;Université de Toulouse, Centre de Recherches sur la Cognition Animale, CNRS, UMR 5169, Université Paul Sabatier, 118 Route de Narbonne, Toulouse, 31062, France;CNRS, IPBS, Institut de Pharmacologie et de Biologie Structurale, 205 Route de Narbonne, Toulouse, 31077, France

关键词: Sufentanil;    Regional anaesthesia;    Plantar incision;    Pain;    Opioid induced hyperalgesia;    Naloxone;    Levobupivacaine;    Diabetes;   

Others  :  1221480
DOI  :  10.1186/s12967-015-0575-0

 received in 2014-12-12, accepted in 2015-06-16,  发布年份 2015

【 摘 要 】

Background

Diabetic neuropathy is one of the most common complications of diabetes and causes various problems in daily life. The aim of this study was to assess the effect of regional anaesthesia on post surgery opioid induced hyperalgesia in diabetic and non-diabetic mice.

Methods

Diabetic and non-diabetic mice underwent plantar surgery. Levobupivacaine and sufentanil were used before surgery, for sciatic nerve block (regional anaesthesia) and analgesia, respectively. Diabetic and non-diabetic groups were each randomly assigned to three subgroups: control, no sufentanil and no levobupivacaine; sufentanil and no levobupivacaine; sufentanil and levobupivacaine. Three tests were used to assess pain behaviour: mechanical nociception; thermal nociception and guarding behaviours using a pain scale.

Results

Sufentanil, alone or in combination with levobupivacaine, produced antinociceptive effects shortly after administration. Subsequently, sufentanil induced hyperalgesia in diabetic and non-diabetic mice. Opioid-induced hyperalgesia was enhanced in diabetic mice. Levobupivacaine associated to sufentanil completely prevented hyperalgesia in both groups of mice.

Conclusion

The results suggest that regional anaesthesia can decrease opioid-induced hyperalgesia in diabetic as well as in non-diabetic mice. These observations may be clinically relevant for the management of diabetic patients.

【 授权许可】

   
2015 Gomez-Brouchet et al.

【 图 表 】

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