Neoadjuvant treatment of melanoma: case reports and review

Experimental Hematology & Oncology

Eddy C Hsueh²  Kevin A Brueske²  Shachar Laks¹ 

[1] Columbia Surgical Associates, Columbia, Missouri and the Division of General Surgery, Saint Louis University, St. Louis, Missouri, USA;Department of Surgery, Saint Louis University, 3635 Vista at Grand Blvd., St. Louis, Missouri 63110, USA

关键词: Neoadjuvant therapy;    Ipilimumab;    Vemurafenib;    Metastatic melanoma;   

Others  :  810666
DOI  :  10.1186/2162-3619-2-30

 received in 2013-08-28, accepted in 2013-11-04,  发布年份 2013

【 摘 要 】

Neoadjuvant therapy is an under-utilized regimen for the treatment of metastatic melanoma. The use of this approach has been increasing in other tumor types. Neoadjuvant therapy may reduce occult circulating tumor cell burden in the face of bulky disease and afford a real time evaluation of treatment effectiveness. Neoadjuvant approach can also provide preoperative histologic and molecular analysis of treated tissue that may guide the postoperative treatment planning in patients with resectable metastatic melanoma lesions. The putative benefits of better margin control and clearance of occult systemic disease would theoretically improve surgical outcome. With the advent of effective agents against metastatic melanoma, this common approach to the treatment of rectal cancer, metastatic colon cancer, and breast cancer should also be evaluated as a viable treatment strategy for advanced stage melanoma.

【 授权许可】

   
2013 Laks et al.; licensee BioMed Central Ltd.

【 图 表 】

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