Motor development of infants exposed to maternal human immunodeficiency virus (HIV) but not infected

International Archives of Medicine

Luiz Carlos de Abreu²  Adriana G Oliveira²  Cícero Cruz Macedo²  Sophia Motta Gallo¹  Carlos Mendes Tavares³  Vitor E Valenti⁴  Carlos Bandeira de Mello Monteiro²  Mahmi Fujimori²  Paulo Rogério Gallo¹  Dafne Herrero² 

[1] Departamento de Saúde Materno-Infantil da Faculdade de saúde, Pública da Universidade de São Paulo, São Paulo, Brasil;Laboratório de Delineamento e Escrita Científica. Departamento de Ciências Básicas, Faculdade de Medicina do ABC, Av. Príncipe de Gales, 821, 09060-650, Santo André, SP, Brasil;Universidade da Integração Internacional da Lusofonia Afro-Brasileira, Instituto de Ciências Sociais Aplicadas, Campus da Liberdade Centro, 62790000, Redenção, CE, Brasil;Departamento de Fonoaudiologia, Faculdade de Filosofia e Ciências, UNESP, Av. Hygino Muzzi Filho, 737, 17525-900, Marília, SP, Brasil

关键词: Physiotherapy;    Early intervention;    HIV/AIDS;    Assessment;    Motor development;   

Others  :  802848
DOI  :  10.1186/1755-7682-6-45

 received in 2012-11-28, accepted in 2013-10-28,  发布年份 2013

【 摘 要 】

Background

To assess the motor development of infants exposed to maternal human immunodeficiency virus (HIV).

Methods

Thirty infants were assessed in the period from November 2009 to March 2010 at the AIDS Reference and Training Centre, in São Paulo, Brazil. The assessment instrument used in the research was the Alberta Infant Motor Scale (AIMS). All 30 infants used the antiretroviral drug properly for 42 consecutive days, in accordance with the protocol of the World Health Organization.

Results

Out of the total number of infants, 27 (90%) had proper motor performance and 3 (10%) presented motor delay, according to the AIMS.

Discussion

This study demonstrated that only 10% of the assessed group had developmental delay and no relation with environmental variables was detected, such as maternal level of education, social and economic issues, maternal practices, attendance at the day care center, and drug use during pregnancy. It is important to emphasize the necessity of studies with a larger number of participants.

【 授权许可】

   
2013 Herrero et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Ratnayake EC, Caldera M, Perera P, Gamage R: Isolated trigeminal nerve palsy with motor involvement as a presenting manifestation of multiple sclerosis in an equatorial region - a case report. Int Arch Med 2012, 5:17. BioMed Central Full Text
• [2]Silva F, Arias-Carrión O, Teixeira S, Velasques B, Peressutti C, Paes F, Basile LF, Menéndez-González M, Murillo-Rodríguez E, Cagy M, Piedade R, Nardi AE, Machado S, Ribeiro P: Functional coupling of sensorimotor and associative areas during a catching ball task: a qEEG coherence study. Int Arch Med 2012, 5:9. BioMed Central Full Text
• [3]Ribacoba R, Menéndez-González M, Calleja S, Salas-Puig J, de la Vega V: Partial motor status epilepticus as a clinical manifestation of carotid stenosis. Int Arch Med 2010, 3:18. BioMed Central Full Text
• [4]Manoel EJ: Motor Development: changing patterns, increasing complexity. Rev Paul Educ Fis 2000, 3:35-54.
• [5]Brum EHM, Scherman L: Ties and early childhood development: theoretical approach at-risk birth. Ciência e saúde coletiva 2004, 9:457-467.
• [6]Silva PL, Santos DCC, Gonçalves VMG: Influence of maternal practices in the motor development of infants from 6 to 12 months of life. Rev Bras fisioter 2006, 10:225-231.
• [7]Flehmig I: Normal development and deviations in its infancy. São Paulo: Livraria Atheneu; 2000:09-45.
• [8]Brazelton TB: Climaxes of child development. São Paulo: Martins Fonseca; 1994:339.
• [9]Tecklin JS: Pediatric Physical Therapy. Porto Alegre: Artmed; 2002:570p.
• [10]Rouquayrol MZ: Epidemiology and Health. Rio de Janeiro: MEDSI; 2003:527p.
• [11]Marcondes E: Environmental factors of the growth of the child. J Hum Growth Develop 1991, 1:15-43.
• [12]Al-Khindi T, Zakzanis KK, Van Gorp WG: Does antiretroviral therapy improve HIV-associated cognitive impairment? A quantitative review of the literature. J Int Neuropsychol Soc 2011, 17:956-969.
• [13]Ndikom CM, Onibokun A: Knowledge and behaviour of nurse/midwives in the prevention of vertical transmission of HIV in Owerri, Imo State. Nigeria: a cross-sectional study. BMC Nurs 2007, 6:9. BioMed Central Full Text
• [14]Newell ML: Reducing childhood mortality in poor countries. Transactions of Trans R Soc Trop Med Hyg 2003, 97:22-24.
• [15]Moodley D, Moodley J: HIV-1 infection: an indication for caesarean section? Int J Obstetric Anesthesia 2000, 9:221-224.
• [16]Yoshimoto CE, Diniz EMA, Vaz FAC: Clinical and laboratory evolution of newborns of HIV-positive mothers. Rev Assoc Med Bras 2005, 51:100-105.
• [17]UNAids: The WHO and the response to AIDS in Brazil. Brazil: Joint United Nations Programme on Hiv/Aids; 2008:32p.
• [18]Matida LH: Transmission of HIV, Syphilis and Hepatitis B in the state of São Paulo. São Paulo: Instituto de Saúde; 2010:p.203.
• [19]Fernandes RCSC, Ribas GF, Pires SD, Gomes AM, Medina AE: Persistent operational challenges not determine the reduction of mother to child transmission of HIV. J Pediatr 2010, 86:503-508.
• [20]Matida LH, Ramos NA Jr, Moncau JEC, Marcopito LF, Marques HHS, Succi RMC: AIDS through vertical transmission: survival analysis of cases followed between 1983 and 2002 in different regions of Brazil. Cad Saude Publica 2007, 23:435-444.
• [21]Silva EB, Grotto HZW, Vilela MM: Clinical aspects and complete blood counts in children exposed to HIV-1: comparison between patients infected and uninfected. J Pediatria 2001, 77:503-511.
• [22]Ivers LC, Appleton SC, Wang B, Jerome JG, Cullen KA, Smith Fawzi MC: HIV-free survival and morbidity among formula-fed infants in a prevention of mother-to-child transmission of HIV program in rural Haiti. AIDS Res Ther 2011, 8:37. BioMed Central Full Text
• [23]Brito AM, Sousa JL, Luna CF, Dourado I: Trend of vertical transmission of AIDS after antiretroviral therapy in Brazil. Rev Saude Publica 2006, 4:18-22.
• [24]Smith R, Malee K, Charurat M, Magder L, Mellins C, Macmillan C, Hittleman J, Lasky T, Llorente A, Moye J: Timing of perinatal human immunodeficiency virus type 1 infection and rate of neurodevelopment. The Women and Infant Transmission Study Group. Pediatr Infect Dis J 2000, 19:862-871.
• [25]Piper MC, Darrah J: Alberta Infant Motor Scale. Philadelphia: WB Sauders; 1994.
• [26]Negrini SFBM: Study neurodevelopment of children born to HIV positive mothers in Ribeirão Preto, Brazil. Dissertation: Master of Science; 2004.
• [27]Ribeiro J, Beltrame TS: Features and neuromotor biopsicossocias of infants with a history of biological risk. Fisioter mov 2010, 23:25-34.
• [28]Pretti LC, Milan JC, Foschiani MA, Raniero EP, Pereira K: Characterization of environmental factors and neck control in infants born preterm. Fisioter mov 2010, 23:239-250.
• [29]Paiva SS, Galvão MTG, Pagliuca LMF, Almeida PC: Nonverbal communication mother / son in the presence of maternal HIV in an experimental setting. Rev Latino-Am Enfermagem 2010, 18:41-47.
• [30]Galvão MTG, Cunha GH, Machado MMT: Dilemmas and conflicts of being a mother in the presence of HIV / AIDS. Rev Bras Enferm 2010, 63:371-376.
• [31]Eyler FD, Behnke M: Early development of infants exposed to drugs prenatally. Clin Perinatol 1999, 26:107-150.
• [32]Jelsma J, Davids N, Ferguson G: The motor development of orphaned children with and without HIV: pilot exploration of foster care and residential placement. BMC Pediatr 2011, 11:11. BioMed Central Full Text
• [33]Reger M, Welsh R, Razani J, Martin DJ, Boone KB: A meta-analysis of the neuropsychological sequelae of HIV infection. J Inter Neuropsycholog Soc 2002, 8:410-424.
• [34]Machado MMT, Galvão MTG, Lindsay AC, Cunha AJLA, Leite AJM, Leite RD: Sociodemographic conditions of children aged zero to two years of mothers with HIV / AIDS, Fortaleza, CE, Brazil. Rev Bras Saúde Mater Infant 2010, 10:377-382.
• [35]Culnane M, Fowler MG, Lee SS, McSherry G, Brady M, O’Donell K: Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. JAMA 1999, 281:151-157.
• [36]Haidar FH, Oliveira UF, Nascimento LFC: Maternal education: correlation with obstetric indicators. Cad Saude Publica 2001, 17:1025-1029.
• [37]Barcellos C, Acosta LMW, Lisboa E, Bastos FI: Surveillance of HIV transmission: socioeconomic indicators and health care coverage. Rev Saude Publica 2009, 43:1006-1014.
• [38]De Vries MW: Babies brain and culture: optimizing neurodevelopment on the savanna. Acta Pediatric Suppl 1999, 429:43-48.
• [39]Santos DCC: Motor development during the first year of life: a comparison between a group of Brazilian and American infants. Campinas (SP): Universidade Estadual de Campinas; 2001.
• [40]Capute AJ: Normal gross motor development: the influences of races, sex and socio- economic status. Dev Med Child Neurol 1985, 27:635-643.
• [41]Mei J: The northern chinese custom of rearing babies in sandbags. In Motor Development: aspects of normal and delayed development. Edited by Van Rossum JHA, Laszlo JI. Amsterdã: VU University Press; 1994.
• [42]Rezende MA, Beteli VC, Santos JLF: Follow-up of the child’s motor abilities in day-care centers and pre-schools. Rev Latino-Am Enfermagem 2010, 13:619-625.
• [43]Hermanides HS, Vught LA, Voigt R, Muskiet FD, Durand A, Osch GV, Wever SK, Gerstenbluth I, Smit C, Duits AJ: Developing quality indicators for the care of HIV-infected pregnant women in the Dutch Caribbean. AIDS Res Ther 2011, 8:32. BioMed Central Full Text