Sustained choroid plexus function in human elderly and Alzheimer’s disease patients

Fluids and Barriers of the CNS

Conrad E Johanson²  Reynold Spector¹ 

[1] Department of Medicine, Robert Wood Johnson Medical School, 105 Stone Hill Road, Colts Neck, NJ 07722, USA;Department of Neurosurgery, Alpert Medical School at Brown University, 593 Eddy Street, Providence, RI 02903, USA

关键词: CSF formation rate;    CSF vitamins;    Blood-CSF barrier;    Choroidal epithelium;    Sodium vitamin C transporter 2;    Na-K-Cl cotransporter;    Reduced folate carrier;    Methyltetrahydrofolate carrier;    CSF K homeostasis;    CSF pH and bicarbonate;    CSF acid–base balance;    Cerebrospinal fluid;    Albumin;    Transthyretin;    Folate;    Ascorbic acid;   

Others  :  806435
DOI  :  10.1186/2045-8118-10-28

 received in 2013-07-29, accepted in 2013-09-18,  发布年份 2013

【 摘 要 】

We and other investigators have postulated deterioration of essential choroid plexus (CP) functions in some elderly and especially Alzheimer’s disease patients based on apparent anatomical, histological and pathological changes in CP. We have termed this putative phenomenon CP failure. By focusing on four essential energy-requiring CP functions, specifically ascorbic acid (AA) and folate transport from blood into CSF, transthyretin synthesis and secretion into CSF, and electrolyte/acid–base balance in CSF, we were able to evaluate the hypothesis of CP failure by reviewing definitive human data. In both healthy elderly and Alzheimer’s disease patients, the CP functions normally to transport AA and folates actively from blood into CSF, synthesize and secrete transthyretin into CSF, and maintain CSF acid–base balance and ion concentrations. These human CSF compositional data provide no support for the notion of CP failure in elderly humans and Alzheimer’s disease patients.

【 授权许可】

   
2013 Spector and Johanson; licensee BioMed Central Ltd.

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