Nek family of kinases in cell cycle, checkpoint control and cancer

Cell Division

Vuk Stambolic³  Nasir Haider²  Previn Dutt³  Larissa Moniz¹ 

[1] Centre for Cell Signalling, Barts Cancer Institute, Queen Mary University of London (QMUL), London EC1M 6BQ, UK;Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada;Ontario Cancer Institute/University Health Network, Toronto, Ontario, M5G 2M9, Canada

关键词: cancer;    cilia;    checkpoint control;    cell cycle;    Nek family;   

Others  :  792979
DOI  :  10.1186/1747-1028-6-18

 received in 2011-10-14, accepted in 2011-10-31,  发布年份 2011

【 摘 要 】

Early studies in lower Eukaryotes have defined a role for the members of the NimA related kinase (Nek) family of protein kinases in cell cycle control. Expansion of the Nek family throughout evolution has been accompanied by their broader involvement in checkpoint regulation and cilia biology. Moreover, mutations of Nek family members have been identified as drivers behind the development of ciliopathies and cancer. Recent advances in studying the physiological roles of Nek family members utilizing mouse genetics and RNAi-mediated knockdown are revealing intricate associations of Nek family members with fundamental biological processes. Here, we aim to provide a comprehensive account of our understanding of Nek kinase biology and their involvement in cell cycle, checkpoint control and cancer.

【 授权许可】

   
2011 Moniz et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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