Xtreme Everest 2: unlocking the secrets of the Sherpa phenotype?

Extreme Physiology & Medicine

Michael PW Grocott³  Michael G Mythen²  Rajendra Kumar BC¹  Kay Mitchell³  Denny ZH Levett³  Edward Gilbert-Kawai²  Daniel S Martin² 

[1] Nepal Health Research Council, Ramshah Path, Kathmandu 44601, Nepal;NIHR University College London Hospitals Biomedical Research Centre Research & Development, Maple House 1st floor 149 Tottenham Court Road, London W1T 7NF, UK;NIHR Southampton Respiratory Biomedical Research Unit, Southampton SO16 5ST, UK

关键词: Epigenetics;    Nitric Oxide;    Mitochondrion;    Microcirculation;    Intensive care;    Critical care;    Sherpa;    Hypoxia;    Oxygen;    Altitude;   

Others  :  820108
DOI  :  10.1186/2046-7648-2-30

 received in 2013-05-08, accepted in 2013-09-12,  发布年份 2013

【 摘 要 】

Xtreme Everest 2 (XE2) was part of an ongoing programme of field, laboratory and clinical research focused on human responses to hypoxaemia that was conducted by the Caudwell Xtreme Everest Hypoxia Research Consortium. The aim of XE2 was to characterise acclimatisation to environmental hypoxia during a standardised ascent to high altitude in order to identify biomarkers of adaptation and maladaptation. Ultimately, this may lead to novel diagnostic and treatment strategies for the pathophysiological hypoxaemia and cellular hypoxia observed in critically ill patients. XE2 was unique in comparing participants drawn from two distinct populations: native ancestral high-altitude dwellers (Sherpas) and native lowlanders. Experiments to study the microcirculation, mitochondrial function and the effect that nitric oxide metabolism may exert upon them were focal to the scientific profile. In addition, the genetic and epigenetic (methylation and histone modification) basis of observed differences in phenotype was explored. The biological samples and phenotypic metadata already collected during XE2 will be analysed as an independent study. Data generated will also contribute to (and be compared with) the bioresource obtained from our previous observational high-altitude study, Caudwell Xtreme Everest (2007).

【 授权许可】

   
2013 Martin et al.; licensee BioMed Central Ltd.

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