Estrogen and androgen receptor expression in surface epithelium and inclusion cyst in the ovary of premenopausal and postmenopausal women

Journal of Ovarian Research

Enrique Pedernera³  Horacio Lopez-Basave²  Azucena Hernandez-Martinez¹  Clementina Espinola-Zetina¹  Maria J Gomora³  Delia Perez-Montiel²  Flavia Morales-Vasquez²  Carmen Mendez³ 

[1] Hospital Militar de Especialidades de la Mujer y Neonatologia. Secretaria de la Defensa Nacional, Mexico, DF, Mexico;FMV Departamento de Oncologia Medica, Instituto Nacional de Cancerologia, DPM Departamento de Anatomia Patologica, HLB Departamento de Cirugia Oncologica, Mexico, DF, Mexico;Departamento de Embriologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510, Mexico, DF, Mexico

关键词: Cervical carcinoma;    Menopause;    Androgen receptor;    Estrogen receptor;    Human ovary;    Ovarian surface epithelium;    Epithelial inclusion cysts;   

Others  :  803742
DOI  :  10.1186/1757-2215-6-85

 received in 2013-09-13, accepted in 2013-11-23,  发布年份 2013

【 摘 要 】

Background

The importance of surface epithelium and epithelial inclusion cysts in the ovary arises from studies demonstrating that these structures are susceptible to epithelial ovarian cancer development. The expression of estrogen receptor alpha (ER alpha), androgen receptor (AR), in epithelial cells of the ovary from premenopausal and postmenopausal women is interesting because sexual steroid hormones are involved in cell growth and differentiation.

Methods

The presence of ER alpha, AR, and the orphan G protein-coupled receptor 30 (GPR30) was demonstrated by immunofluorescence in ovaries obtained from 79 pre and postmenopausal patients, undergoing histero-salpingo-oophorectomy for proliferative gynecological diseases. The proportion of patients that displayed positive reaction for estrogen and androgen receptors in epithelial cells of the ovary was evaluated according to menopausal status and associated pathology.

Results

The proportion of patients that displayed a positive receptor expression in the epithelial cells of the ovarian surface and cortical inclusion cysts shows that ER alpha is present in 20 of 79 patients (0.25), AR in 33 of 79 (0.42) and GPR30 in 38 of 55 (0.69). There are no differences in ER alpha, AR, and GPR30 expression between pre and postmenopausal patients and considering the associated pathology, proportions for ER alpha and GPR30 are similar. The patients with cervical cancer show a higher proportion of AR expression in epithelial cells of the ovary, which is statistically significant (P < 0.01) compared with patients with other proliferative diseases.

Conclusions

The presence of ER alpha, AR, and GPR30 in the surface epithelial ovarian cells and its derivatives are observed with a proportion that is specific for each receptor. The proportion of expression for these receptors in the epithelial cells of the ovary does not change after menopause. The proportion of ovaries with AR positive epithelial cells in patients with cervical squamous carcinoma is higher compared with other gynecological pathologies.

【 授权许可】

   
2013 Mendez et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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