Superficial epithelioma with sebaceous differentiation involving the eyelid: a case report

Journal of Medical Case Reports

Miguel N Burnier²  Conrad C Kavalec³  Vasco Bravo-Filho²  Natalia Vila²  Mohammed F Qutub²  Patrick T Logan²  Pablo Zoroquiain²  Sultan S Aldrees¹ 

[1] Department of Ophthalmology, King Saud University, Riyadh, Saudi Arabia;Henry C. Witelson Ocular Pathology Laboratory, McGill University, 3775 Rue University, Room 216, Montreal, Quebec, Canada;Department of Ophthalmology, McGill University, Montreal, Canada

关键词: Superficial epithelioma with sebaceous differentiation;    Muir–Torre syndrome;    Eyelid;   

Others  :  1180840
DOI  :  10.1186/1752-1947-8-466

 received in 2014-08-21, accepted in 2014-12-01,  发布年份 2014

【 摘 要 】

Introduction

Superficial epithelioma with sebaceous differentiation is a rare benign epithelial neoplasm. It usually involves the head, neck or the back of a middle-age person. To the best of our knowledge, two ocular cases have been reported in the literature.

Case presentation

A 46-year-old man of Italian descent, with a known history of testicular seminoma treated by orchiectomy with chemotherapy and radiotherapy, presented with a tan-colored lesion measuring 4mm in diameter in his right upper lid that had been growing over 10 months. It was clinically diagnosed as papilloma. An excisional biopsy was done. On histological examination, the lesion was a well-circumscribed and sharply demarcated epithelial tumor attached to the overlying epidermis and characterized by plate-like proliferation of basaloid to squamous cells with clusters of mature sebaceous cells and foci of ductal differentiation. After a follow-up period of 5 months, no recurrence of the lesion has been documented.

Conclusions

Superficial epithelioma with sebaceous differentiation is part of the differential diagnoses of eyelid lesions. Arguments in the literature about the correct nomenclature of superficial epithelioma with sebaceous differentiation have resulted in under-diagnosed cases. The benign histological features and the lack of recurrence support its benign nature. Although no clear association has linked superficial epithelioma with sebaceous differentiation with Muir–Torre syndrome, further clinical correlation and close follow up for patients are recommended.

【 授权许可】

   
2014 Aldrees et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Rothko K, Farmer ER, Zeligman I: Superficial epithelioma with sebaceous differentiation. Arch Dermatol 1980, 116(3):329-331.
• [2]Kato N, Ueno H: Superficial epithelioma with sebaceous differentiation. J Dermatol 1992, 19(3):190-194.
• [3]Leboeuf NR, Mahalingam M: Acanthomatous superficial sebaceous hamartoma? A study of six cases with clarification of the nomenclature. J Cutan Pathol 2007, 34(11):865-870.
• [4]Akasaka T, Imamura Y, Tomichi N, Kon S: A case of superficial epithelioma with sebaceous differentiation. J Dermatol 1994, 21(4):264-267.
• [5]Friedman KJ, Boudreau S, Farmer ER: Superficial epithelioma with sebaceous differentiation. J Cutan Pathol 1987, 14(4):193-197.
• [6]Lee MJ, Kim YC, Lew W: A case of superficial epithelioma with sebaceous differentiation. Yonsei Med J 2003, 44(2):347-350.
• [7]Sachez Yus E, Requena L, Simon P, del Rio E: Sebomatricoma: a unifying term that encompasses all benign neoplasms with sebaceous differentiation. Am J Dermatopathol 1995, 17(3):213-221.
• [8]Sanchez Yus E, Requena L, Simon P, Sanchez M: Complex adnexal tumor of the primary epithelial germ with distinct patterns of superficial epithelioma with sebaceous differentiation, immature trichoepithelioma, and apocrine adenocarcinoma. Am J Dermatopathol 1992, 14(3):245-252.
• [9]Vaughan TK, Sau P: Superficial epithelioma with sebaceous differentiation. J Am Acad Dermatol 1990, 23(4 Pt 1):760-762.
• [10]Kawachi Y, Fujisawa Y, Furuta J, Nakamura Y, Ishii Y, Otsuka F: Superficial epithelioma with sebaceous differentiation: immunohistochemical study of keratinocyte differentiation markers. Eur J Dermatol: EJD 2011, 21(6):1016-1017.
• [11]Requena L, Kuztner H, Farina MC: Pigmented and nested sebomatricoma or seborrheic keratosis with sebaceous differentiation? Am J Dermatopathol 1998, 20(4):383-388.
• [12]Haake DL, Minni JP, Nowak M, Abenoza P, Nousari CH: Reticulated acanthoma with sebaceous differentiation. Lack of association with Muir-Torre syndrome. Am J Dermatopathol 2009, 31(4):391-392.
• [13]Shalin SC, Lyle S, Calonje E, Lazar AJ: Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications. Histopathology 2010, 56(1):133-147.