期刊论文详细信息
BMC Veterinary Research
Serum amyloid A (SAA) concentration after training sessions in Arabian race and endurance horses
Anna Winnicka3  Antoni Schollenberger3  Ewa Szarska2  Lucjan Witkowski1  Anna Cywinska3 
[1] Laboratory of Veterinary Epidemiology and Economic Faculty of Veterinary Medicine, Warsaw University of Life Sciences – SGGW, Warsaw, Poland;Military Institute of Hygiene and Epidemiology, Warsaw, Poland;Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Warsaw, Poland
关键词: Training;    Endurance horses;    Race horses;    Serum amyloid A;   
Others  :  1119547
DOI  :  10.1186/1746-6148-9-91
 received in 2013-01-29, accepted in 2013-04-26,  发布年份 2013
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【 摘 要 】

Background

Serum amyloid A (SAA) is the major acute phase protein in horses. Its concentration increases in various pathologies but also in response to prolonged, strenuous effort. The purpose of this study was to establish whether routine race and endurance training produces changes in the SAA level in Arabian horses. Additionally, the differences between SAA response in experienced endurance horses and endurance horses that were beginning their career were investigated.

Results

There were no changes in SAA concentrations after race training and endurance training in experienced horses. In horses that were beginning their endurance training, exercise produced an increase in SAA level as compared with rest level.

Conclusion

In Arabians, the SAA concentration seems to be a good indicator of endurance training but is useless in race training. The routine training of experienced horses, which were prepared for long distance rides, did not promote any changes in the SAA level. In contrast, a significant increase in the SAA concentration was observed in horses that were beginning their endurance training and were only prepared for moderate distance rides and underwent the same effort. Further research is needed to elucidate whether this difference reflects too heavy training or adaptation to an increasing workload. Additionally, the adaptation to long distance rides in Arabians may include a reduced acute phase response.

【 授权许可】

   
2013 Cywinska et al.; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1]Tizard IR: Veterinary immunology an introduction. 8th edition. St. Louis, Missouri: Saunders Elsevier; 2009.
  • [2]Eckersall PD: Acute phase proteins as biomarkers of disease in companion and laboratory animals. In Proceedings of the 57th Annual Meeting of the American College of Veterinary Pathologists and American Society for Veterinary Clinical Pathology. Tucson, Arizona; 2006:47-52.
  • [3]Petersen HH, Nielsen JP, Heegaard PMH: Application of acute phase protein measurements in veterinary clinical chemistry. Vet Res 2004, 35:163-187.
  • [4]Gruys E, Toussaint MJM, Niewold TA, Koopmans SJ: Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B 2005, 11:1045-1056.
  • [5]Crisman MV, Scarratt WK, Zimmerman KL: Blood proteins and inflammation in the horse. Vet Clin North Am Equine Pract 2008, 24:285-297.
  • [6]Cray C: Acute phase proteins in animals. Prog Mol Biol Transl Sci 2012, 105:113-150.
  • [7]Jacobsen S, Andersen PH: The acute phase protein serum amyloid A (SAA) as a marker of inflammation in horses. Equine Vet Educ 2007, 19:38-46.
  • [8]Hulten C, Tulamo RM, Suominen MM, Burvaqll K, Marhaug G, Forsberg M: A noncompetitive chemiluminescence enzyme immunoassay for the equine acute phase protein serum amyloid A (SAA) – a clinically useful inflammatory marker in the horse. Vet Immunol Immunopathol 1999, 68:267-281.
  • [9]Hulten C, Gronlund U, Hirvonen J, Tulamo RM, Suominen MM, Marhaug G, Forsberg M: Dynamics in serum of the inflammatory markers serum amyloid A (SAA), haptoglobin, fibrinogen and α2 – globulins during induced non – infectious arthritis in the horse. Equine Vet J 2002, 34:699-704.
  • [10]Pepys MB, Baltz ML, Tennent GA: Serum amyloid A protein (SAA) in horses: objective measurement of the acute phase response. Equine Vet J 1989, 21:106-109.
  • [11]Jacobsen S, Nielsen JV, Kjelgaard-Hansen M, Toelboell T, Fjeldborg J, Halling-Thomsen M, Martinussen T, Thoefner MB: Acute phase response to surgery of varying intensity in horses: a preliminary study. Vet Surg 2009, 38:762-769.
  • [12]Jacobsen S, Jensen JC, Frei S, Jensen AL, Thoefner MB: Use of serum amyloid A and other acute phase reactants to monitor the inflammatory response after castration in horses: a field study. Equine Vet J 2005, 37:552-556.
  • [13]Pollock PJ, Prendergast M, Schumacher J, Bellenger CR: Effects of surgery on the acute phase response in clinically normal and diseased horses. Vet Rec 2005, 156:538-542.
  • [14]Copas VE, Durham AE, Stratford CH, McGorum BC, Waggett B, Pirie RS: In equine grass sickness, serum amyloid A and fibrinogen are elevated, and can aid differential diagnosis from non-inflammatory causes of colic. Vet Rec 2013.
  • [15]Nunokawa Y, Fujinaga T, Taira T, Okumura M, Yamashita K, Tsunoda N, Hagio M: Evaluation of serum amyloid A protein as an acute-phase reactive protein in horses. J Vet Med Sci 1993, 55:1011-1016.
  • [16]Vandenplas ML, Moore JN, Barton MH, Roussel AJ, Cohen ND: Concentrations of serum amyloid A and lipopolysaccharide-binding protein in horses with colic. Am J Vet Res 2005, 66:1509-1516.
  • [17]Hulten C, Demmers S: Serum amyloid A (SAA) as an aid in the management of infectious disease in foal: comparison with total leukocyte count, neutrophil count and fibrinogen. Equine Vet J 2002, 34:693-698.
  • [18]Hobo S, Niwa H, Anzai T: Evaluation of serum amyloid A and surfactant protein D in sera for identification of the clinical condition of horses with bacterial pneumonia. J Vet Med Sci 2007, 69:827-830.
  • [19]Hulten C, Sandgren B, Skioldebrand E, Klingeborn B, Marhaug G, Forsberg M: The acute phase protein serum amyloid A (SAA) as an inflammatory marker in equine influenza virus infection. Acta Vet Scand 1999, 40:323-333.
  • [20]Casella S, Fazio F, Giannetto C, Giusdice E, Piccione G: Influence of transportation on serum concentrations of acute phase proteins in horse. Res Vet Sci 2012, 93:914-917.
  • [21]Kjelgaard-Hansen M, Jacobsen S: Assay validation and diagnostic applications of major acute-phase protein testing in companion animals. Clin Lab Med 2011, 31:51-70.
  • [22]Eckersall PD: Recent advances and future prospects for the use of acute phase proteins as markers of disease in animals. Vet Med Rev 2000, 151:577-584.
  • [23]Fallon KE, Fallon SK, Boston T: The acute phase response and exercise: court and field sports. Br J Sports Med 2001, 35:170-173.
  • [24]Wakshlag JJ, Stokol T, Geske SM, Greger CE, Angle CT, Gillette RL: Evaluation of exercise – induced changes in concentrations of C – reactive protein and serum biochemical values in sled dogs competing a long – distance endurance race. Am J Vet Res 2010, 71:1207-1213.
  • [25]Cywinska A, Gorecka R, Szarska E, Witkowski L, Dziekan P, Schollenberger A: Serum amyloid A as a potential indicator of the status of endurance horses. Equine Vet J 2010, 42(Suppl 38):23-27.
  • [26]Cywińska A, Szarska E, Gorecka R, Witkowski L, Hecold M, Berezowski A, Schollenberger A, Winnicka A: Acute phase protein concentrations after limited distance and long distance endurance rides in horses. Res Vet Sci 2012, 93:1402-1406.
  • [27]Ducharme NG, Fortier LA, Kraus MS, Hobo S, Mohammed HO, McHugh MP, Hackett RP, Soderholm LV, Mitchell LM: Effect of a tart cherry juice blend on exercise-induced muscle damage in horses. Am J Vet Res 2009, 70:758-763.
  • [28]Liburt NR, Adams AA, Betancourt A, Horohov DW, McKeever KH: Exercise-induced increases in inflammatory cytokines in muscle and blood of horses. Equine Vet J 2010, 42(Suppl 38):280-288.
  • [29]Horohov DW, Sinatra ST, Chopra RK, Jankowitz S, Betancourt A, Bloomer RJ: The effect of exercise and nutritional supplementation on proinflammatory cytokine expression in young racehorses during training. J Equine Vet Sci 2012, 32:805-815.
  • [30]McBride S, Mills D: Psychological factors affecting equine performance. BMC Vet Res 2012, 8:180. BioMed Central Full Text
  • [31]Smith BP: Large Animal Internal Medicine. 4th edition. St. Louis, Missouri: Elsevier; 2008.
  • [32]Fazio F, Assenza A, Tosto F, Casella S, Piccione G, Caola G: Training and haematochemical profile in Thoroughbreds and Standardbreds: A longitudinal study. Livestock Sci 2011, 141:221-226.
  • [33]Hinchcliff H, Kaneps A, Geor R: Equine Sports Medicine and Surgery. Edinburgh: Saunders; 2004.
  • [34]Iversen PO, Stokland A, Rolstad B, Benestad HB: Adrenaline-induced leukocytosis: recruitment of blood cells from rat spleen, bone marrow and lymphatics. Eur J Appl Physiol Occup Physiol 1994, 68:219-227.
  • [35]Gabriel H, Müller HJ, Kettler K, Brechtel L, Urhausen A, Kindermann W: Increased phagocytic capacity of the blood, but decreased phagocytic activity per individual circulating neutrophil after an ultradistance run. Eur J Appl Physiol Occup Physiol 1995, 71:281-284.
  • [36]Korhonen PA, Lilius EM, Hyyppä S, Räsänen LA, Pösö AR: Production of reactive oxygen species in neutrophils after repeated bouts of exercise in standardbred trotters. J Vet Med A 2000, 47:565-573.
  • [37]Rossdale PD, Burguez PN, Cash RSG: Changes in blood neutrophil/lymphocyte ratio related to adrenocortical function in the horse. Equine Vet J 1982, 14:293-298.
  • [38]Cywińska A, Wyszyńska Z, Górecka R, Szarska E, Witkowski L, Dziekan P, Winnicka A, Schollenberger A: The effect of the 162 km endurance ride on equine peripheral blood neutrophil and lymphocyte functions. Pol J Vet Sci 2010, 13:279-285.
  • [39]Jacobsen S, Kjelgaard-Hansen M, Hagbard Petersen H, Jensen AL: Evaluation of a commercially available human serum amyloid A (SAA) turbidometric imunoassay for determination of equine SAA concentrations. Vet J 2006, 172:315-319.
  • [40]Meyer T, Gabriel HH, Rätz M, Müller HJ, Kindermann W: Anaerobic exercise induces moderate acute phase response. Med Sci Sports Exerc 2001, 33:549-555.
  • [41]Beaufort Cottage Laboratories reference ranges. http://www.rossdales.com/downloads/rossdalesci21_ref_ranges7.pdf webcite
  • [42]Mattusch F, Dufaux B, Heine O, Mertens I, Rost R: Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. Int J Sports Med 2000, 21:21-24.
  • [43]Fazio F, Assenza A, Tosto F, Casella S, Piccione G, Caola G: Modifications of some acute phase proteins and the white blood cell count in thoroughbreds during training. Vet Rec 2010, 167:370-372.
  • [44]Woods JA, Vieira VJ, Keylock KT: Exercise, inflammation and innate immunity. Immunol Allergy Clin North Am 2009, 29:381-393.
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