期刊论文详细信息
Cancer Cell International
Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties
Hsueh-Wei Chang4  Jen-Yang Tang6  Chi-Chen Yeh5  Fang-Rong Chang5  Hurng-Wern Huang1  Ming-Feng Hou3  Jin-Ching Lee2 
[1] Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan;Department of Biotechnology, College of Life Science Kaohsiung Medical University, Kaohsiung, Taiwan;Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan;Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
关键词: Anti-cancer;    Antinociceptive;    Inflammation;    Antioxidant;    ROS;    Algae;   
Others  :  793648
DOI  :  10.1186/1475-2867-13-55
 received in 2013-04-07, accepted in 2013-05-27,  发布年份 2013
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【 摘 要 】

For their various bioactivities, biomaterials derived from marine algae are important ingredients in many products, such as cosmetics and drugs for treating cancer and other diseases. This mini-review comprehensively compares the bioactivities and biological functions of biomaterials from red, green, brown, and blue-green algae. The anti-oxidative effects and bioactivities of several different crude extracts of algae have been evaluated both in vitro and in vivo. Natural products derived from marine algae protect cells by modulating the effects of oxidative stress. Because oxidative stress plays important roles in inflammatory reactions and in carcinogenesis, marine algal natural products have potential for use in anti-cancer and anti-inflammatory drugs.

【 授权许可】

   
2013 Lee et al.; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1]Arif JM, Al-Hazzani AA, Kunhi M, Al-Khodairy F: Novel marine compounds: Anticancer or genotoxic? J Biomed Biotechnol 2004, 2004(2):93-98.
  • [2]MacArtain P, Gill CI, Brooks M, Campbell R, Rowland IR: Nutritional value of edible seaweeds. Nutr Rev 2007, 65(12 Pt 1):535-543.
  • [3]Cerna M: Seaweed proteins and amino acids as nutraceuticals. Adv Food Nutr Res 2011, 64:297-312.
  • [4]Misurcova L, Skrovankova S, Samek D, Ambrozova J, Machu L: Health benefits of algal polysaccharides in human nutrition. Adv Food Nutr Res 2012, 66:75-145.
  • [5]Tabarsa M, Rezaei M, Ramezanpour Z, Waaland JR: Chemical compositions of the marine algae Gracilaria salicornia (Rhodophyta) and Ulva lactuca (Chlorophyta) as a potential food source. J Sci Food Agric 2012, 92(12):2500-2506.
  • [6]Rajapakse N, Kim SK: Nutritional and digestive health benefits of seaweed. Adv Food Nutr Res 2011, 64:17-28.
  • [7]Souza BW, Cerqueira MA, Martins JT, Quintas MA, Ferreira AC, Teixeira JA, Vicente AA: Antioxidant potential of two red seaweeds from the Brazilian coasts. J Agric Food Chem 2011, 59(10):5589-5594.
  • [8]Coura CO, de Araujo IW, Vanderlei ES, Rodrigues JA, Quindere AL, Fontes BP, de Queiroz IN, de Menezes DB, Bezerra MM, e Silva AA, et al.: Antinociceptive and anti-inflammatory activities of sulphated polysaccharides from the red seaweed Gracilaria cornea. Basic Clin Pharmacol Toxicol 2012, 110(4):335-341.
  • [9]Yeh ST, Lin YC, Huang CL, Chen JC: White shrimp Litopenaeus vannamei that received the hot-water extract of Gracilaria tenuistipitata showed protective innate immunity and up-regulation of gene expressions after low-salinity stress. Fish Shellfish Immunol 2010, 28(5–6):887-894.
  • [10]Genovese G, Tedone L, Hamann MT, Morabito M: The Mediterranean red alga Asparagopsis: a source of compounds against Leishmania. Mar Drugs 2009, 7(3):361-366.
  • [11]Yeh CC, Tseng CN, Yang JI, Huang HW, Fang Y, Tang JY, Chang FR, Chang HW: Antiproliferation and induction of apoptosis in Ca9-22 oral cancer cells by ethanolic extract of Gracilaria tenuistipitata. Molecules 2012, 17(9):10916-10927.
  • [12]Badal S, Gallimore W, Huang G, Tzeng TR, Delgoda R: Cytotoxic and potent CYP1 inhibitors from the marine algae Cymopolia barbata. Org Med Chem Lett 2012, 2(1):21. BioMed Central Full Text
  • [13]da Matta CB, de Souza ET, de Queiroz AC, de Lira DP, de Araujo MV, Cavalcante-Silva LH, de Miranda GE, de Araujo-Junior JX, Barbosa-Filho JM, de Oliveira Santos BV, et al.: Antinociceptive and anti-inflammatory activity from algae of the genus Caulerpa. Mar Drugs 2011, 9(3):307-318.
  • [14]Wijesinghe WA, Jeon YJ: Exploiting biological activities of brown seaweed Ecklonia cava for potential industrial applications: a review. Int J Food Sci Nutr 2012, 63(2):225-235.
  • [15]Pak W, Takayama F, Mine M, Nakamoto K, Kodo Y, Mankura M, Egashira T, Kawasaki H, Mori A: Anti-oxidative and anti-inflammatory effects of spirulina on rat model of non-alcoholic steatohepatitis. J Clin Biochem Nutr 2012, 51(3):227-234.
  • [16]Ku CS, Pham TX, Park Y, Kim B, Shin MS, Kang I, Lee J: Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-kappaB pathway in macrophages and splenocytes. Biochim Biophys Acta 2013, 1830(4):2981-2988.
  • [17]Romay C, Armesto J, Remirez D, Gonzalez R, Ledon N, Garcia I: Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae. Inflamm Res 1998, 47(1):36-41.
  • [18]Li Y, Zhang X: Recombinant Microcystis viridis lectin as a potential anticancer agent. Pharmazie 2010, 65(12):922-923.
  • [19]Faulkner DJ: Marine natural products. Nat Prod Rep 2002, 19(1):1-48.
  • [20]Liu M, Hansen PE, Lin X: Bromophenols in marine algae and their bioactivities. Mar Drugs 2011, 9(7):1273-1292.
  • [21]Bhakuni DS, Rawat DS (Eds): Bioactive marine natural products. Netherlands: Springer; 2005.
  • [22]Kim SK, Ta QV: Potential beneficial effects of marine algal sterols on human health. Adv Food Nutr Res 2011, 64:191-198.
  • [23]Jimenez-Escrig A, Gomez-Ordonez E, Ruperez P: Seaweed as a source of novel nutraceuticals: sulfated polysaccharides and peptides. Adv Food Nutr Res 2011, 64:325-337.
  • [24]Kim SK, Li YX: Medicinal benefits of sulfated polysaccharides from sea vegetables. Adv Food Nutr Res 2011, 64:391-402.
  • [25]Hsu BY, Tsao CY, Chiou TK, Hwang PA, Hwang DF: HPLC determination for prostaglandins from seaweed Gracilaria gigas. Food Control 2007, 18(6):639-645.
  • [26]Kim SK, Pangestuti R: Biological activities and potential health benefits of fucoxanthin derived from marine brown algae. Adv Food Nutr Res 2011, 64:111-128.
  • [27]Turkez H, Gurbuz H, Aydin E, Aslan A, Dirican E: The evaluation of the genotoxic and oxidative damage potentials of Ulothrix tenuissima (Kutz.) in vitro. Toxicol Ind Health 2012, 28(2):147-151.
  • [28]Pavia H, Aberg P: Spatial variation in polyphenolic content of Ascophyllum nodosum (Fucales, Phaeophyta). Hydrobiologia 1996, 327:199-203.
  • [29]Jung KJ, Jung CH, Pyeun JH, Choi YJ: Changes of food components in Mesangi (Capsosiphon fulvescens), Gashiparae (Enteromorpha prolifera), and Cheonggak (Codium fragile) depending on harvest times. J Korean Soc Food Sci Nutr 2005, 34:687-693.
  • [30]Grunewald N, Groth I, Alban S: Evaluation of seasonal variations of the structure and anti-inflammatory activity of sulfated polysaccharides extracted from the red alga Delesseria sanguinea (Hudson) Lamouroux (Ceramiales, Delesseriaceae). Biomacromolecules 2009, 10(5):1155-1162.
  • [31]Kelman D, Posner EK, McDermid KJ, Tabandera NK, Wright PR, Wright AD: Antioxidant activity of Hawaiian marine algae. Mar Drugs 2012, 10(2):403-416.
  • [32]Heo SJ, Jeon YJ, Lee J, Kim HT, Lee KW: Antioxidant effect of enzymatic hydrolyzate from a Kelp. Ecklonia cava. Algae 2003, 18(4):341-347.
  • [33]Heo SJ, Lee KW, Song CB, Jeon YJ: Antioxidant activity of enzymatic extracts from brown seaweeds. Algae 2003, 18:71-81.
  • [34]Heo SJ, Park EJ, Lee KW, Jeon YJ: Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresour Technol 2005, 96(14):1613-1623.
  • [35]Kang KA, Bu HD, Park DS, Go GM, Jee Y, Shin T, Hyun JW: Antioxidant activity of ethanol extract of Callophyllis japonica. Phytother Res 2005, 19(6):506-510.
  • [36]Yang JI, Yeh CC, Lee JC, Yi SC, Huang HW, Tseng CN, Chang HW: Aqueous extracts of the edible Gracilaria tenuistipitata are protective against H2O2-induced DNA damage, growth inhibition, and cell cycle arrest. Molecules 2012, 17(6):7241-7254.
  • [37]Chakraborty K, Paulraj R: Sesquiterpenoids with free-radical-scavenging properties from marine macroalga Ulva fasciata Delile. Food Chem 2010, 122:31-41.
  • [38]Meenakshi S, Gnanambigai DM, Mozhi ST, Arumugam M, Balasubramanian T: Total flavanoid and in vitro antioxidant activity of two seaweeds of Rameshwaram coast. Global J Pharmacol 2009, 3(2):59-62.
  • [39]Balaji Raghavendra Rao H, Sathivel A, Devaki T: Antihepatotoxic nature of Ulva reticulata (Chlorophyceae) on acetaminophen-induced hepatoxicity in experimental rats. J Med Food 2004, 7(4):495-497.
  • [40]Shibata T, Ishimaru K, Kawaguchi S, Yoshikawa H, Hama Y: Antioxidant activities of phlorotannins isolated from Japanese Laminariaceae. J Appl Phycol 2008, 20(5):705-711.
  • [41]O’Sullivan AM, O’Callaghan YC, O’Grady MN, Queguineur B, Hanniffy D, Troy DJ, Kerrya JP, O’Brien NM: In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland. Food Chem 2011, 126:1064-1070.
  • [42]O’Sullivan AM, O’Callaghan YC, O’Grady MN, Queguineur B, Hanniffy D, Troy DJ, Kerry JP, O’Brien NM: Assessment of the ability of seaweed extracts to protect against hydrogen peroxide and tert-butyl hydroperoxide induced cellular damage in Caco-2 cells. Food Chem 2012, 134(2):1137-1140.
  • [43]Pant G, Kumar G, Karthik L, Prasuna RG, Rao KVB: Antioxidant activity of methanolic extract of blue green algae Anabaena sp. (Nostocaceae). Eur J Exp Bio 2011, 1(1):156-162.
  • [44]Pinero Estrada JE, Bermejo Bescos P, Villar del Fresno AM: Antioxidant activity of different fractions of Spirulina platensis protean extract. Farmaco 2001, 56(5–7):497-500.
  • [45]Schramm A, Matusik P, Osmenda G, Guzik TJ: Targeting NADPH oxidases in vascular pharmacology. Vasc Pharmacol 2012, 56(5–6):216-231.
  • [46]Rosanna DP, Salvatore C: Reactive oxygen species, inflammation, and lung diseases. Curr Pharm Des 2012, 18(26):3889-3900.
  • [47]Kim YJ, Kim EH, Hahm KB: Oxidative stress in inflammation-based gastrointestinal tract diseases: challenges and opportunities. J Gastroenterol Hepatol 2012, 27(6):1004-1010.
  • [48]Hulsmans M, Van Dooren E, Holvoet P: Mitochondrial reactive oxygen species and risk of atherosclerosis. Curr Atheroscler Rep 2012, 14(3):264-276.
  • [49]Abad MJ, Bedoya LM, Bermejo P: Natural marine anti-inflammatory products. Mini Rev Med Chem 2008, 8(8):740-754.
  • [50]Wang W, Wang SX, Guan HS: The antiviral activities and mechanisms of marine polysaccharides: an overview. Mar Drugs 2012, 10(12):2795-2816.
  • [51]D’Orazio N, Gammone MA, Gemello E, De Girolamo M, Cusenza S, Riccioni G: Marine bioactives: pharmacological properties and potential applications against inflammatory diseases. Mar Drugs 2012, 10(4):812-833.
  • [52]de Almeida CL, Falcao Hde S, Lima GR, Montenegro Cde A, Lira NS, de Athayde-Filho PF, Rodrigues LC, de Souza MF, Barbosa-Filho JM, Batista LM: Bioactivities from marine algae of the genus gracilaria. Int J Mol Sci 2011, 12(7):4550-4573.
  • [53]Chen KJ, Tseng CK, Chang FR, Yang JI, Yeh CC, Chen WC, Wu SF, Chang HW, Lee JC: Aqueous extract of the edible Gracilaria tenuistipitata inhibits hepatitis C viral replication via cyclooxygenase-2 suppression and reduces virus-induced inflammation. PLoS One 2013, 8(2):e57704.
  • [54]Talyshinsky MM, Souprun YY, Huleihel MM: Anti-viral activity of red microalgal polysaccharides against retroviruses. Cancer Cell Int 2002, 2(1):8. BioMed Central Full Text
  • [55]Lee DS, Park WS, Heo SJ, Cha SH, Kim D, Jeon YJ, Park SG, Seo SK, Choi JS, Park SJ, et al.: Polyopes affinis alleviates airway inflammation in a murine model of allergic asthma. J Biosci 2011, 36(5):869-877.
  • [56]Lim CS, Jin DQ, Sung JY, Lee JH, Choi HG, Ha I, Han JS: Antioxidant and anti-inflammatory activities of the methanolic extract of Neorhodomela aculeate in hippocampal and microglial cells. Biol Pharm Bull 2006, 29(6):1212-1216.
  • [57]Chatter R, Ben Othman R, Rabhi S, Kladi M, Tarhouni S, Vagias C, Roussis V, Guizani-Tabbane L, Kharrat R: In vivo and in vitro anti-inflammatory activity of neorogioltriol, a new diterpene extracted from the red algae Laurencia glandulifera. Mar Drugs 2011, 9(7):1293-1306.
  • [58]Ayyad SE, Al-Footy KO, Alarif WM, Sobahi TR, Bassaif SA, Makki MS, Asiri AM, Al Halwani AY, Badria AF, Badria FA: Bioactive C15 acetogenins from the red alga Laurencia obtusa. Chem Pharm Bull(Tokyo) 2011, 59(10):1294-1298.
  • [59]Shin ES, Hwang HJ, Kim IH, Nam TJ: A glycoprotein from Porphyra yezoensis produces anti-inflammatory effects in liposaccharide-stimulated macrophages via the TLR4 signaling pathway. Int J Mol Med 2011, 28(5):809-815.
  • [60]Lee HJ, Dang HT, Kang GJ, Yang EJ, Park SS, Yoon WJ, Jung JH, Kang HK, Yoo ES: Two enone fatty acids isolated from Gracilaria verrucosa suppress the production of inflammatory mediators by down-regulating NF-kappaB and STAT1 activity in lipopolysaccharide-stimulated RAW 264.7 cells. Arch Pharm Res 2009, 32(3):453-462.
  • [61]Ryan S, O’Gorman DM, Nolan YM: Evidence that the marine-derived multi-mineral Aquamin has anti-inflammatory effects on cortical glial-enriched cultures. Phytother Res 2011, 25(5):765-767.
  • [62]Cavalcante-Silva LH, da Matta CB, de Araujo MV, Barbosa-Filho JM, de Lira DP, de Oliveira Santos BV, de Miranda GE, Alexandre-Moreira MS: Antinociceptive and anti-inflammatory activities of crude methanolic extract of red alga Bryothamnion triquetrum. Mar Drugs 2012, 10(9):1977-1992.
  • [63]Chaves Lde S, Nicolau LA, Silva RO, Barros FC, Freitas AL, Aragao KS, Ribeiro Rde A, Souza MH, Barbosa AL, Medeiros JV: Antiinflammatory and antinociceptive effects in mice of a sulfated polysaccharide fraction extracted from the marine red algae Gracilaria caudata. Immunopharmacol Immunotoxicol 2013, 35(1):93-100.
  • [64]de Sousa AA, Benevides NM, de Freitas Pires A, Fiuza FP, Queiroz MG, Morais TM, Pereira MG, Assreuy AM: A report of a galactan from marine alga Gelidium crinale with in vivo anti-inflammatory and antinociceptive effects. Fundam Clin Pharmacol 2013, 27(2):173-180.
  • [65]Bitencourt Fda S, Figueiredo JG, Mota MR, Bezerra CC, Silvestre PP, Vale MR, Nascimento KS, Sampaio AH, Nagano CS, Saker-Sampaio S, et al.: Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis. Naunyn Schmiedebergs Arch Pharmacol 2008, 377(2):139-148.
  • [66]Silva LM, Lima V, Holanda ML, Pinheiro PG, Rodrigues JA, Lima ME, Benevides NM: Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea. Biol Pharm Bull 2010, 33(5):830-835.
  • [67]Lavy A, Naveh Y, Coleman R, Mokady S, Werman MJ: Dietary Dunaliella bardawil, a beta-carotene-rich alga, protects against acetic acid-induced small bowel inflammation in rats. Inflamm Bowel Dis 2003, 9(6):372-379.
  • [68]Jin DQ, Lim CS, Sung JY, Choi HG, Ha I, Han JS: Ulva conglobata, a marine algae, has neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells. Neurosci Lett 2006, 402(1–2):154-158.
  • [69]Margret RJ, Kumaresan S, Ravikumar S: A preliminary study on the anti-inflammatory activity of methanol extract of Ulva lactuca in rat. J Environ Biol 2009, 30(5 Suppl):899-902.
  • [70]Renju GL, Muraleedhara Kurup G, Saritha Kumari CH: Anti-inflammatory activity of lycopene isolated from Chlorella marina on Type II Collagen induced arthritis in Sprague Dawley rats. Immunopharmacol Immunotoxicol 2013, 35(2):282-291.
  • [71]Caroprese M, Albenzio M, Ciliberti MG, Francavilla M, Sevi A: A mixture of phytosterols from Dunaliella tertiolecta affects proliferation of peripheral blood mononuclear cells and cytokine production in sheep. Vet Immunol Immunopathol 2012, 150(1–2):27-35.
  • [72]Bitencourt MA, Dantas GR, Lira DP, Barbosa-Filho JM, de Miranda GE, Santos BV, Souto JT: Aqueous and methanolic extracts of Caulerpa mexicana suppress cell migration and ear edema induced by inflammatory agents. Mar Drugs 2011, 9(8):1332-1345.
  • [73]Vanderlei ES, Patoilo KK, Lima NA, Lima AP, Rodrigues JA, Silva LM, Lima ME, Lima V, Benevides NM: Antinociceptive and anti-inflammatory activities of lectin from the marine green alga Caulerpa cupressoides. Int Immunopharmacol 2010, 10(9):1113-1118.
  • [74]Rodrigues JA, Vanderlei ES, Silva LM, Araujo IW, Queiroz IN, Paula GA, Abreu TM, Ribeiro NA, Bezerra MM, Chaves HV, et al.: Antinociceptive and anti-inflammatory activities of a sulfated polysaccharide isolated from the green seaweed Caulerpa cupressoides. Pharmacol Rep 2012, 64(2):282-292.
  • [75]Kim SK, Lee DY, Jung WK, Kim JH, Choi I, Park SG, Seo SK, Lee SW, Lee CM, Yea SS, et al.: Effects of Ecklonia cava ethanolic extracts on airway hyperresponsiveness and inflammation in a murine asthma model: role of suppressor of cytokine signaling. Biomed Pharmacother 2008, 62(5):289-296.
  • [76]Kim TH, Bae JS: Ecklonia cava extracts inhibit lipopolysaccharide induced inflammatory responses in human endothelial cells. Food Chem Toxicol 2010, 48(6):1682-1687.
  • [77]Kim MM, Rajapakse N, Kim SK: Anti-inflammatory effect of Ishige okamurae ethanolic extract via inhibition of NF-kappaB transcription factor in RAW 264.7 cells. Phytother Res 2009, 23(5):628-634.
  • [78]Medeiros VP, Queiroz KC, Cardoso ML, Monteiro GR, Oliveira FW, Chavante SF, Guimaraes LA, Rocha HA, Leite EL: Sulfated galactofucan from Lobophora variegata: anticoagulant and anti-inflammatory properties. Biochemistry (Mosc) 2008, 73(9):1018-1024.
  • [79]Paiva AA, Castro AJ, Nascimento MS, Will LS, Santos ND, Araujo RM, Xavier CA, Rocha FA, Leite EL: Antioxidant and anti-inflammatory effect of polysaccharides from Lobophora variegata on zymosan-induced arthritis in rats. Int Immunopharmacol 2011, 11(9):1241-1250.
  • [80]Sarithakumari CH, Renju GL, Kurup GM: Anti-inflammatory and antioxidant potential of alginic acid isolated from the marine algae, Sargassum wightii on adjuvant-induced arthritic rats. Inflammopharmacology 2012. http://www.ncbi.nlm.nih.gov/pubmed/23179138 webcite
  • [81]Kawashima T, Murakami K, Nishimura I, Nakano T, Obata A: A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria. Int J Mol Med 2012, 29(3):447-453.
  • [82]Siqueira RC, da Silva MS, de Alencar DB, Pires Ade F, de Alencar NM, Pereira MG, Cavada BS, Sampaio AH, Farias WR, Assreuy AM: In vivo anti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algae Lobophora variegata. Pharm Biol 2011, 49(2):167-174.
  • [83]Dore CM, Faustino Alves MG, Will LS, Costa TG, Sabry DA, de Souza Rego LA, Accardo CM, Rocha HA, Filgueira LG, Leite EL: A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects. Carbohydr Polym 2013, 91(1):467-475.
  • [84]Farias WR, Lima PC, Rodrigues NV, Siqueira RC, Amorim RM, Pereira MG, Assreuy AM: A novel antinociceptive sulphated polysaccharide of the brown marine alga Spatoglossum schroederi. Nat Prod Commun 2011, 6(6):863-866.
  • [85]Heo SJ, Yoon WJ, Kim KN, Ahn GN, Kang SM, Kang DH, Affan A, Oh C, Jung WK, Jeon YJ: Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages. Food Chem Toxicol 2010, 48(8–9):2045-2051.
  • [86]Kim SK, Himaya SW: Medicinal effects of phlorotannins from marine brown algae. Adv Food Nutr Res 2011, 64:97-109.
  • [87]Yoon WJ, Heo SJ, Han SC, Lee HJ, Kang GJ, Kang HK, Hyun JW, Koh YS, Yoo ES: Anti-inflammatory effect of sargachromanol G isolated from Sargassum siliquastrum in RAW 264.7 cells. Arch Pharm Res 2012, 35(8):1421-1430.
  • [88]Kim MM, Kim SK: Effect of phloroglucinol on oxidative stress and inflammation. Food Chem Toxicol 2010, 48(10):2925-2933.
  • [89]Shih CM, Cheng SN, Wong CS, Kuo YL, Chou TC: Antiinflammatory and antihyperalgesic activity of C-phycocyanin. Anesth Analg 2009, 108(4):1303-1310.
  • [90]Lee JC, Son YO, Pratheeshkumar P, Shi X: Oxidative stress and metal carcinogenesis. Free Radic Biol Med 2012, 53(4):742-757.
  • [91]Kongara S, Karantza V: The interplay between autophagy and ROS in tumorigenesis. Frontiers in oncology 2012, 2:171.
  • [92]Park SH, Ozden O, Jiang H, Cha YI, Pennington JD, Aykin-Burns N, Spitz DR, Gius D, Kim HS: Sirt3, mitochondrial ROS, ageing, and carcinogenesis. Int J Mol Sci 2011, 12(9):6226-6239.
  • [93]Okoh V, Deoraj A, Roy D: Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer. Biochim Biophys Acta 2011, 1815(1):115-133.
  • [94]Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR: Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J 2009, 418(1):29-37.
  • [95]Fayyaz S, Farooqi AA: miRNA and TMPRSS2-ERG do not mind their own business in prostate cancer cells. Immunogenetics 2013, 65(5):315-332.
  • [96]Farooqi AA, Fayyaz S, Rashid S: Upon the tightrope in prostate cancer: two acrobats on the same tightrope to cross the finishline. Mol Cell Biochem 2012, 364(1–2):53-57.
  • [97]Dutta KK, Zhong Y, Liu YT, Yamada T, Akatsuka S, Hu Q, Yoshihara M, Ohara H, Takehashi M, Shinohara T, et al.: Association of microRNA-34a overexpression with proliferation is cell type-dependent. Cancer Sci 2007, 98(12):1845-1852.
  • [98]Vendramini-Costa DB, Carvalho JE: Molecular link mechanisms between inflammation and cancer. Curr Pharm Des 2012, 18(26):3831-3852.
  • [99]Poehlmann A, Kuester D, Malfertheiner P, Guenther T, Roessner A: Inflammation and Barrett’s carcinogenesis. Pathol Res Pract 2012, 208(5):269-280.
  • [100]Martin-Cordero C, Leon-Gonzalez AJ, Calderon-Montano JM, Burgos-Moron E, Lopez-Lazaro M: Pro-oxidant natural products as anticancer agents. Curr Drug Targets 2012, 13(8):1006-1028.
  • [101]Farooqi AA, Butt G, Razzaq Z: Algae extracts and methyl jasmonate anti-cancer activities in prostate cancer: choreographers of ‘the dance macabre’. Cancer Cell Int 2012, 12(1):50. BioMed Central Full Text
  • [102]Yen CY, Chiu CC, Haung RW, Yeh CC, Huang KJ, Chang KF, Hseu YC, Chang FR, Chang HW, Wu YC: Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis; DNA damage and ROS induction. Mutat Res 2012, 747(2):253-258.
  • [103]Zandi K, Tajbakhsh S, Nabipour I, Rastian Z, Yousefi F, Sharafian S, Sartavi K: In vitro antitumor activity of Gracilaria corticata (a red alga) against Jurkat and molt-4 human cancer cell lines. Afr J Biotechnol 2010, 9(40):6787-6790.
  • [104]Zandi K, Ahmadzadeh S, Tajbakhsh S, Rastian Z, Yousefi F, Farshadpour F, Sartavi K: Anticancer activity of Sargassum oligocystum water extract against human cancer cell lines. Eur Rev Med Pharmacol Sci 2010, 14(8):669-673.
  • [105]Yeh CC, Yang JI, Lee JC, Tseng CN, Chan YC, Hseu YC, Tang JY, Chuang LY, Huang HW, Chang FR, et al.: Anti-proliferative effect of methanolic extract of Gracilaria tenuistipitata on oral cancer cells involves apoptosis, DNA damage, and oxidative stress. BMC Complement Altern Med 2012, 12(1):142. BioMed Central Full Text
  • [106]Kim JY, Yoon MY, Cha MR, Hwang JH, Park E, Choi SU, Park HR, Hwang YI: Methanolic extracts of Plocamium telfairiae induce cytotoxicity and caspase-dependent apoptosis in HT-29 human colon carcinoma cells. J Med Food 2007, 10(4):587-593.
  • [107]Park HY, Lim CW, Kim YK, Yoon HD, Lee KJ: Immunostimulating and anticancer activities of hot water extract from Capsosiphon fulvescens. J Korean Soc Appl Biol Chem 2006, 49:343-348.
  • [108]Kwon MJ, Nam TJ: A polysaccharide of the marine alga Capsosiphon fulvescens induces apoptosis in AGS gastric cancer cells via an IGF-IR-mediated PI3K/Akt pathway. Cell Biol Int 2007, 31(8):768-775.
  • [109]Kim YM, Kim IH, Nam TJ: Induction of apoptosis signaling by glycoprotein of Capsosiphon fulvescens in human gastric cancer (AGS) cells. Nutr Cancer 2012, 64(5):761-769.
  • [110]Nakajima K, Yokoyama A, Nakajima Y: Anticancer effects of a tertiary sulfonium compound, dimethylsulfoniopropionate, in green sea algae on Ehrlich ascites carcinoma-bearing mice. J Nutr Sci Vitaminol 2009, 55(5):434-438.
  • [111]Go H, Hwang HJ, Nam TJ: A glycoprotein from Laminaria japonica induces apoptosis in HT-29 colon cancer cells. Toxicol In Vitro 2010, 24(6):1546-1553.
  • [112]Ermakova S, Sokolova R, Kim SM, Um BH, Isakov V, Zvyagintseva T: Fucoidans from brown seaweeds Sargassum hornery, Eclonia cava, Costaria costata: structural characteristics and anticancer activity. Appl Biochem Biotechnol 2011, 164(6):841-850.
  • [113]Costa LS, Fidelis GP, Telles CB, Dantas-Santos N, Camara RB, Cordeiro SL, Costa MS, Almeida-Lima J, Melo-Silveira RF, Oliveira RM, et al.: Antioxidant and antiproliferative activities of heterofucans from the seaweed Sargassum filipendula. Mar Drugs 2011, 9(6):952-966.
  • [114]Satomi Y: Fucoxanthin induces GADD45A expression and G1 arrest with SAPK/JNK activation in LNCap human prostate cancer cells. Anticancer Res 2012, 32(3):807-813.
  • [115]Khan Z, Bhadouria P, Bisen PS: Nutritional and therapeutic potential of Spirulina. Curr Pharm Biotechnol 2005, 6(5):373-379.
  • [116]Shih C, Teicher BA: Cryptophycins: a novel class of potent antimitotic antitumor depsipeptides. Curr Pharm Des 2001, 7(13):1259-1276.
  • [117]Corbett TH, Valeriote FA, Demchik L, Polin L, Panchapor C, Pugh S, White K, Knight J, Jones J, Jones L, et al.: Preclinical anticancer activity of cryptophycin-8. J Exp Ther Oncol 1996, 1(2):95-108.
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