Self-reported adverse reactions and IgE sensitization to common foods in adults with asthma

Clinical and Translational Allergy

L. Ekerljung¹  E. Telemo³  S. Sjölander²  L. Johanson¹  G. Rentzos⁴ 

[1] Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg, Sweden;R&D, ImmunoDiagnostics, Thermofischer Scientific, Uppsala, Sweden;Department for Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;Section of Allergology, University Hospital of Sahlgrenska, Gothenburg, 413 45, Sweden

关键词: Epidemiology;    Food allergy;    Asthma;   

Others  :  1219567
DOI  :  10.1186/s13601-015-0067-6

 received in 2015-03-21, accepted in 2015-05-25,  发布年份 2015

【 摘 要 】

Background

There is very few data available on the prevalence of food hypersensitivity among adults with asthma. The aim of this study was to explore the prevalence of self-reported adverse reactions and IgE sensitization to the different foods and to determine the spectrum and the prevalence of food-related gastrointestinal symptoms in adults with and with no asthma.

Methods

A cross sectional study based on interviews and questionnaire responses from 1527 subjects, aged 18–75 years of age, from Västra Götaland in Sweden, as part of the larger West Sweden Asthma Study. IgE analyses were performed in sera from all subjects.

Results

Fifty three percent of adults with asthma reported adverse reactions to foods compared to 30 % of non-asthmatics. Most asthmatics reported symptoms from eating hazelnut, followed by other nuts, birch-related foods, milk, peanut and shellfish. Furthermore, adults with asthma experienced significantly more often gastrointestinal symptoms from hazelnut, apple and milk and were found to significantly more often be sensitized to the most common foods compared to the non-asthmatic subjects. The asthmatics showed a significant correlation between IgE to both hazelnut and birch and self-reported symptoms after ingestion of hazelnut and to a lesser extent to almonds.

Conclusions

The prevalence of self-reported adverse reactions and sensitization to the most common foods was much higher among the asthmatic subjects. Hazelnut was the food that asthmatics most frequently experienced adverse reactions from, and the strong correlation between IgE to hazelnut and birch indicate that the observed adverse reactions are partly due to sensitization to allergens from the PR-10 family.

【 授权许可】

   
2015 Rentzos et al.

【 图 表 】

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【 参考文献 】

• [1]Chafen JJ, Newberry SJ, Riedl MA, Bravata DM, Maglione M, Suttorp MJ, Sundaram V, Paige NM, Towfigh A, Hulley BJ, Shekelle PG: Diagnosing and managing common food allergies: a systematic review. JAMA 2010, 303(18):1848-1856.
• [2]Nwaru BI, Hickstein L, Panesar SS, Muraro A, Werfel T, Cardona V, Dubois AE, Halken S, Hoffmann-Sommergruber K, Poulsen LK, Roberts G, Van Ree R, Vlieg-Boerstra BJ, Sheikh A: The epidemiology of food allergy in Europe: a systematic review and meta-analysis. Allergy 2014, 69(1):62-75.
• [3]Sicherer SH, Sampson HA: Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol 2014, 133(2):291-307.
• [4]Berns SH, Halm EA, Sampson HA, Sicherer SH, Busse PJ, Wisnivesky JP: Food allergy as a risk factor for asthma morbidity in adults. J Asthma 2007, 44(5):377-381.
• [5]Roberts G, Patel N, Levi-Schaffer F, Habibi P, Lack G: Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study. J Allergy Clin Immunol 2003, 112(1):168-174.
• [6]Bock SA, Munoz-Furlong A, Sampson HA: Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001, 107(1):191-193.
• [7]Oehling A, Baena Cagnani CE: Food allergy and child asthma. Allergol Immunopathol (Madr) 1980, 8(1):7-14.
• [8]Roberts G, Lack G: Food allergy and asthma–what is the link? Paediatr Respir Rev 2003, 4(3):205-212.
• [9]Woods RK, Thien F, Raven J, Walters EH, Abramson M: Prevalence of food allergies in young adults and their relationship to asthma, nasal allergies, and eczema. Ann Allergy Asthma Immunol 2002, 88(2):183-189.
• [10]Blanco Carmona JG, Juste Picon S, Garces Sotillos M, Rodriguez GP: Occupational asthma in the confectionary industry caused by sensitivity to egg. Allergy 1992, 47(2 Pt 2):190-191.
• [11]Boulet LP, Laberge F: Occupational asthma to fish. Occup Environ Med 2014, 71(11):804.
• [12]James JM, Crespo JF: Allergic reactions to foods by inhalation. Curr Allergy Asthma Rep 2007, 7(3):167-174.
• [13]Caffarelli C, Deriu FM, Terzi V, Perrone F, De Angelis G, Atherton DJ: Gastrointestinal symptoms in patients with asthma. Arch Dis Child 2000, 82(2):131-135.
• [14]Kivity S, Fireman E, Sade K: Bronchial hyperactivity, sputum analysis and skin prick test to inhalant allergens in patients with symptomatic food hypersensitivity. Isr Med Assoc J 2005, 7(12):781-784.
• [15]Powell N, Huntley B, Beech T, Knight W, Knight H, Corrigan CJ: Increased prevalence of gastrointestinal symptoms in patients with allergic disease. Postgrad Med J 2007, 83(977):182-186.
• [16]Tielemans MM, Jaspers Focks J, van Rossum LG, Eikendal T, Jansen JB, Laheij RJ, van Oijen MG: Gastrointestinal symptoms are still prevalent and negatively impact health-related quality of life: a large cross-sectional population based study in The Netherlands. PLoS One 2013, 8(7):e69876.
• [17]Louis E, Louis R, Drion V, Bonnet V, Lamproye A, Radermecker M, Belaiche J: Increased frequency of bronchial hyperresponsiveness in patients with inflammatory bowel disease. Allergy 1995, 50(9):729-733.
• [18]White AM, Stevens WH, Upton AR, O’Byrne PM, Collins SM: Airway responsiveness to inhaled methacholine in patients with irritable bowel syndrome. Gastroenterology 1991, 100(1):68-74.
• [19]Wallaert B, Desreumaux P, Copin MC, Tillie I, Benard A, Colombel JF, Gosselin B, Tonnel AB, Janin A: Immunoreactivity for interleukin 3 and 5 and granulocyte/macrophage colony-stimulating factor of intestinal mucosa in bronchial asthma. J Exp Med 1995, 182(6):1897-1904.
• [20]Ronmark EP, Ekerljung L, Lotvall J, Toren K, Ronmark E, Lundback B: Large scale questionnaire survey on respiratory health in Sweden: effects of late- and non-response. Respir Med 2009, 103(12):1807-1815.
• [21]Landis JR, Koch GG: The measurement of observer agreement for categorical data. Biometrics 1977, 33(1):159-174.
• [22]Woods RK, Stoney RM, Raven J, Walters EH, Abramson M, Thien FC: Reported adverse food reactions overestimate true food allergy in the community. Eur J Clin Nutr 2002, 56(1):31-36.
• [23]Liu AH, Jaramillo R, Sicherer SH, Wood RA, Bock SA, Burks AW, Massing M, Cohn RD, Zeldin DC: National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005–2006. J Allergy Clin Immunol 2010, 126(4):798-806.
• [24]Patelis A, Gunnbjornsdottir M, Malinovschi A, Matsson P, Onell A, Hogman M, Alving K, Janson C: Population-based study of multiplexed IgE sensitization in relation to asthma, exhaled nitric oxide, and bronchial responsiveness. J Allergy Clin Immunol 2012, 130(2):397-402.
• [25]Vieths S, Scheurer S, Ballmer-Weber B: Current understanding of cross-reactivity of food allergens and pollen. Ann N Y Acad Sci 2002, 964:47-68.
• [26]Eriksson NE, Holmen A: Skin prick tests with standardized extracts of inhalant allergens in 7099 adult patients with asthma or rhinitis: cross-sensitizations and relationships to age, sex, month of birth and year of testing. J Investig Allergol Clin Immunol 1996, 6(1):36-46.
• [27]Eriksson NE, Moller C, Werner S, Magnusson J, Bengtsson U, Zolubas M: Self-reported food hypersensitivity in Sweden, Denmark, Estonia, Lithuania, and Russia. J Investig Allergol Clin Immunol 2004, 14(1):70-79.
• [28]Lieberoth S, Backer V, Kyvik KO, Skadhauge LR, Tolstrup JS, Gronbaek M, Linneberg A, Thomsen SF: Intake of alcohol and risk of adult-onset asthma. Respir Med 2012, 106(2):184-188.
• [29]Linneberg A, Berg ND, Gonzalez-Quintela A, Vidal C, Elberling J: Prevalence of self-reported hypersensitivity symptoms following intake of alcoholic drinks. Clin Exp Allergy 2008, 38(1):145-151.
• [30]Vally H, Thompson PJ: Allergic and asthmatic reactions to alcoholic drinks. Addict Biol 2003, 8(1):3-11.
• [31]Ronmark E, Bjerg A, Perzanowski M, Platts-Mills T, Lundback B: Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden. J Allergy Clin Immunol 2009, 124(2):357-363.
• [32]Ekerljung L, Bossios A, Lotvall J, Olin AC, Ronmark E, Wennergren G, et al.: Multi-symptom asthma as an indication of disease severity in epidemiology. Eur Respir J 2011, 38(4):825-832.
• [33]Kamdar TA, Peterson S, Lau CH, Saltoun CA, Gupta RS, Bryce PJ: Prevalence and characteristics of adult-onset food allergy. J Allergy Clin Immunol Pract 2015, 3(1):114.
• [34]Pallasaho P, Juusela M, Lindqvist A, Sovijarvi A, Lundback B, Ronmark E: Allergic rhinoconjunctivitis doubles the risk for incident asthma–results from a population study in Helsinki. Finland Respir Med 2011, 105(10):1449-1456.
• [35]Warm K, Backman H, Lindberg A, Lundback B, Ronmark E: Low incidence and high remission of allergic sensitization among adults. J Allergy Clin Immunol 2012, 129(1):136-142.
• [36]Strinnholm A, Winberg A, West C, Hedman L, Ronmark E: Food hypersensitivity is common in Swedish schoolchildren, especially oral reactions to fruit and gastrointestinal reactions to milk. Acta Paediatr 2014, 103(12):1290-1296.
• [37]Winberg A, Strinnholm A, Hedman L, West C, Perzanowski M, Ronmark E: High incidence and remission of reported food hypersensitivity in Swedish children followed from 8 to 12years of age - a population based cohort study. Clin Trans Allergy 2014, 4(1):32. BioMed Central Full Text
• [38]Patelis A, Gunnbjornsdottir M, Borres MP, Burney P, Gislason T, Toren K, Forsberg B, Alving K, Malinovschi A, Janson C: Natural history of perceived food hypersensitivity and IgE sensitisation to food allergens in a cohort of adults. PLoS One 2014, 9(1):e85333.
• [39]Benard A, Desreumeaux P, Huglo D, Hoorelbeke A, Tonnel AB, Wallaert B: Increased intestinal permeability in bronchial asthma. J Allergy Clin Immunol 1996, 97(6):1173-1178.
• [40]Lillestol K, Helgeland L, Arslan Lied G, Florvaag E, Valeur J, Lind R, Berstad, A. Indications of ‘atopic bowel’ in patients with self-reported food hypersensitivity. Aliment Pharmacol Ther. 2010;31(10):1112–22.
• [41]Magnusson J, Lin XP, Dahlman-Hoglund A, Hanson LL, Telemo E, Magnusson O, et al.: Seasonal intestinal inflammation in patients with birch pollen allergy. J Allergy Clin Immunol 2003, 112(1):45-50.
• [42]Rentzos G, Lundberg V, Stotzer PO, Pullerits T, Telemo E: Intestinal allergic inflammation in birch pollen allergic patients in relation to pollen season, IgE sensitization profile and gastrointestinal symptoms. Clin Trans Allergy 2014, 4:19. BioMed Central Full Text
• [43]Bohn L, Storsrud S, Tornblom H, Bengtsson U, Simren M: Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life. Am J Gastroenterol 2013, 108(5):634-641.
• [44]Simren M, Mansson A, Langkilde AM, Svedlund J, Abrahamsson H, Bengtsson U, et al.: Food-related gastrointestinal symptoms in the irritable bowel syndrome. Digestion 2001, 63(2):108-115.
• [45]O’Keefe AW, De Schryver S, Mill J, Mill C, Dery A, Ben-Shoshan M: Diagnosis and management of food allergies: new and emerging options: a systematic review. J Asthma Allergy 2014, 7:141-164.