The use of oral recombinant feline interferon omega in two cats with type II diabetes mellitus and concurrent feline chronic gingivostomatitis syndrome

Irish Veterinary Journal

Luís Tavares¹  Maria MRE Niza¹  David McGahie²  Maria TV Brito¹  Solange Gil¹  Rodolfo O Leal¹ 

[1] Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA), Faculdade de Medicina Veterinária, Technical University of Lisbon (TULisbon), Av. Universidade Técnica, 1300-477 Lisbon, Portugal;Virbac, 13e rue LID – BP 27 F, 06511 Carros cedex, France

关键词: Gingivostomatitis;    Diabetes;    Feline;    Interferon-Omega;   

Others  :  805819
DOI  :  10.1186/2046-0481-66-19

 received in 2013-05-14, accepted in 2013-10-02,  发布年份 2013

【 摘 要 】

Feline Chronic Gingivostomatitis Syndrome (FCGS) is a common disease in clinical practice. Among the therapeutic options available, long-acting corticosteroids are frequently used due to their anti-inflammatory and immunosuppressive properties. Although they may improve the clinical symptoms, they can lead to a progressive form of the disease that becomes refractory to treatment. Furthermore, their direct relationship with type II diabetes mellitus (DM) is well known. Consequently, these drugs are controversial and not recommended for routine management of FCGS. Recombinant feline interferon-omega (rFeIFN-ω) is an immunomodulatory compound. Recently, its daily oral administration has been shown to be successful in treating refractory cases of FCGS. This case study describes two clinical cases of type II DM complicated by FCGS. Both animals were calicivirus positive and they had been previously treated with long-acting corticosteroids, which may have been the major cause of DM. The two cats were treated with glargine insulin (Lantus, starting dose 1 IU/cat twice daily (BID)), achieving remission 10 and 18 weeks later respectively. Considering the difficulty with control of FCGS in these animals, an oral daily dose of rFeIFN-ω was started as an alternative to long-acting corticosteroids. In both cats oral clinical signs gradually improved and 60 days after the start of therapy the owners reported a significant relief of pain during mastication. According to the authors’ knowledge, this is the first case report that describes the successful use of rFeIFN-ω in the management of FCGS in type II diabetic cats, in which long-acting corticosteroids are contraindicated.

【 授权许可】

   
2013 Leal et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Pedersen NC: Inflammatory oral cavity diseases of the cat. Vet Clin North Am Small Anim Pract 1992, 22:1323-1345.
• [2]DeBowes L: Feline Caudal Stomatitis. In Kirk's Current Veterinary Therapy XIV. Volume XIV. Edited by Bonagura J, Twedt D. Missouri: Saunders Elsevier; 2009:476-479.
• [3]Tanney K, Smith M: Oral and Salivary Gland Disorders. In Textbook of Veterinary Internal Medicine: Diseases of the dog and cat. Volume 2. Seventh edition. Edited by Ettinger S, Feldman E. Missouri: Saunders Elsevier; 2010.
• [4]Tenorio AP, Franti CE, Madewell BR, Pedersen NC: Chronic oral infections of cats and their relationship to persistent oral carriage of feline calici-, immunodeficiency, or leukemia viruses. Vet Immunol Immunopathol 1991, 29:1-14.
• [5]Hartmann K: Feline Leukemia Virus. In Infectious Diseases of the Dog and Cat. Fourth edition. Edited by Greene C. Missouri: Saunders Elsevier; 2012:108-136.
• [6]Sellon R, Hartmann K: Feline Immunodeficiency Virus Infection. In Infectious diseases of the dog and cat. 4th edition. Edited by Greene C. Missouri: Saunders Elsevier; 2012:136-149.
• [7]Gaskell R, Dawson S, Radford A: Feline Respiratory Disease. In Infectious Diseases of the Dog and Cat. Fourth edition. Edited by Greene C. Missouri: Saunders Elsevier; 2012:151-162.
• [8]Lommer MJ, Verstraete FJ: Concurrent oral shedding of feline calicivirus and feline herpesvirus 1 in cats with chronic gingivostomatitis. Oral Microbiol Immunol 2003, 18:131-134.
• [9]Sykes J: Feline Calicivirus Infection. In Kirk's Current Veterinary Therapy Volume XIV. Edited by Bonagura J, Twedt D. Missouri: Saunders Elsevier; 2009:1284-1288.
• [10]Rand J: Feline diabetes mellitus. In BSAVA Manual of Canine and Feline Endocrinology. Fourth edition. Edited by Mooney C, Peterson M. Gloucester: BSAVA; 2012:133-147.
• [11]Rand JS, Marshall RD: Diabetes mellitus in cats. Vet Clin North Am Small Anim Pract 2005, 35:211-224.
• [12]Hennet PR, Camy GA, McGahie DM, Albouy MV: Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: a randomised, multi-centre, controlled, double-blind study in 39 cats. J Feline Med Surg 2011, 13:577-587.
• [13]de Mari K, Maynard L, Sanquer A, Lebreux B, Eun HM: Therapeutic effects of recombinant feline interferon-omega on feline leukemia virus (FeLV)-infected and FeLV/feline immunodeficiency virus (FIV)-coinfected symptomatic cats. J Vet Intern Med 2004, 18:477-482.
• [14]Domenech A, Miro G, Collado VM, Ballesteros N, Sanjose L, Escolar E, Martin S, Gomez-Lucia E: Use of recombinant interferon omega in feline retrovirosis: from theory to practice. Vet Immunol Immunopathol 2011, 143:301-306.
• [15]Gil S, Leal RO, Duarte A, McGahie D, Sepulveda N, Siborro I, Cravo J, Cartaxeiro C, Tavares LM: Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter. Res Vet Sci 2013, 94:753-763.
• [16]Ritz S, Egberink H, Hartmann K: Effect of feline interferon-omega on the survival time and quality of life of cats with feline infectious peritonitis. J Vet Intern Med 2007, 21:1193-1197.
• [17]Haid C, Kaps S, Gonczi E, Hassig M, Metzler A, Spiess BM, Richter M: Pretreatment with feline interferon omega and the course of subsequent infection with feline herpesvirus in cats. Vet Ophthalmol 2007, 10:278-284.
• [18]Mihaljevic S: First clinical experiences with omega-interferon in the treatment of chronic gingivitis-stomatitis-oropharyngitis of cats. Der Prakt Tierarzt 2003, 84:350-361.
• [19]Addie D: Feline Coronavirus Infections. In Infectious Diseases of the Dog and Cat. Elsevier edition. Edited by Green C. Missouri: Elsevier; 2012:92-108.
• [20]Bennett N, Greco DS, Peterson ME, Kirk C, Mathes M, Fettman MJ: Comparison of a low carbohydrate-low fiber diet and a moderate carbohydrate-high fiber diet in the management of feline diabetes mellitus. J Feline Med Surg 2006, 8:73-84.
• [21]Marshall RD, Rand JS, Morton JM: Treatment of newly diagnosed diabetic cats with glargine insulin improves glycaemic control and results in higher probability of remission than protamine zinc and lente insulins. J Feline Med Surg 2009, 11:683-691.
• [22]Roomp K, Rand J: Intensive blood glucose control is safe and effective in diabetic cats using home monitoring and treatment with glargine. J Feline Med Surg 2009, 11:668-682.
• [23]Tompkins WA: Immunomodulation and therapeutic effects of the oral use of interferon-alpha: mechanism of action. J Interferon Cytokine Res 1999, 19:817-828.