期刊论文详细信息
European Journal of Medical Research
Raltegravir, tenofovir, and emtricitabine in an HIV-Infected patient with HCV chronic hepatitis, NNRTI intolerance and protease inhibitors-induced severe liver toxicity
PE Manconi2  M Floridia1  LE Weimer1  F Ortu2 
[1] Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome, Italy;Clinic of Infectious Diseases, Department of Medicine and Immunology, University of Cagliari, Italy
关键词: chronic active hepatitis;    emtricitabine;    tenofovir;    raltegravir;    antiretroviral treatment;    HIV/HCV;   
Others  :  1093331
DOI  :  10.1186/2047-783X-15-2-81
 received in 2009-11-26, accepted in 2010-01-21,  发布年份 2010
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【 摘 要 】

Background

in HIV-infected patients with HCV-related chronic hepatitis, liver impairment and drug toxicity may substantially reduce the number of possible therapeutic options.

Case Description

we here describe the case of an HCV-HIV coinfected woman who had repeated severe episodes of drug-related liver toxicity with indinavir, saquinavir, fosamprenavir, and darunavir, with minimal further therapeutic options left in this class. Previous treatment-limiting side effects with efavirenz and nevirapine also precluded use of non-nucleoside reverse transcriptase inhibitors. Introduction of an integrase-inhibitor regimen based on raltegravir, tenofovir, and emtricitabine allowed a prompt achievement of undetectable viral load and a substantial rise of CD4 count to high levels, with no subsequent episodes of hepatic toxicity, and no other side effects.

Conclusions

given the relatively common prevalence of HCV-related chronic hepatitis among people with HIV, raltegravir might represent an important alternative option for a substantial number of patients who cannot be treated with protease inhibitors or NNRTI because of drug-related hepatic toxicity.

【 授权许可】

   
2010 I. Holzapfel Publishers

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