Risk factors for cervical HPV infection and genotypes distribution in HIV-infected South Brazilian women

Infectious Agents and Cancer

Sandra M Pelloso⁴  Marcia E L Consolaro³  Maria D de B Carvalho¹  Angela A F Gravena⁴  Rosangela G Santana²  Raquel P Souza³  Mary M T Irie³  André L P de Abreu³  Fabrícia Gimenes³  Sheila C Rocha-Brischiliari⁴ 

[1] Department of Medicine, State University of Maringá, Paraná, Brazil;Department of Statistics, State University of Maringá, Paraná, Brazil;Department of Clinical Analysis and Biomedicine, State University of Maringá, Paraná, Brazil;Department of Nursing, State University of Maringá, Paraná, Brazil

关键词: Cervical cancer;    Cervical lesions;    Risk factors;    Genotypes;    HPV;    HIV;   

Others  :  801136
DOI  :  10.1186/1750-9378-9-6

 received in 2013-07-16, accepted in 2014-02-03,  发布年份 2014

【 摘 要 】

Background

Human Papillomavirus (HPV) infection is particularly burdensome for women infected with human immunodeficiency virus (HIV), which increases their risk of developing cervical lesions and cancer (CC). We conducted a molecular study of the distribution of cervical HPV genotypes and the risk factors for this infection in HIV-infected Brazilian women.

Findings

Cervical and endocervical samples for Papanicolaou screening and HPV detection were collected from 178 HIV-infected women using highly active antiretroviral therapy (HAART) of Maringá city/Brazil. Risk factors were assessed using a standardized questionnaire, and the data regarding to HIV infection from medical records. HPV was detected by polymerase chain reaction (PCR), and genotyping using PCR-restriction fragment length polymorphism analysis. HIV infection was well controlled, but women with a current CD4+ T lymphocyte count between 200–350 cells/mm³ (37.6%) had a two-fold greater risk of HPV infection than those with > 350 cells/mm³ (26.4%). HPV was associated with parity ≥3, hormonal contraceptive use and current smoker. HPV infection occurred with high frequency (46.6%) but a low frequency of cervical abnormalities was detected (7.30%), mainly low-grade squamous intraephitelial cervical lesions (LSIL) (84.6%). A high frequency of multiple HPV infections was detected (23.0%), and the most frequent HPV genotype was HPV-72 (6.7%), followed by −16, -31 and -51 (6.14% each).

Conclusions

We showed that HAART use does not protect HIV-infected women from HPV, but appear to exert some protection against cervical lesions development. This study provides other important information about risk factors and cervical HPV in HIV-infected women, which can contribute to planning protocols.

【 授权许可】

   
2014 Rocha-Brischiliari et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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