Determination of antibiotic consumption index for animal originated foods produced in animal husbandry in Iran, 2010

Journal of Environmental Health Science Engineering

Mohammd Jalali¹  Maryam Mirlohi¹  Fathollah Aalipour¹ 

[1] Food Security Research Center, Department of Food Technology, School of Nutrition and Food Science, Isfahan University of Medical Science, Hezargrib Street, Isfahan, Iran

关键词: Iran;    Exposure;    Food;    Animal farm;    Antibiotic;   

Others  :  805708
DOI  :  10.1186/2052-336X-12-42

 received in 2013-02-24, accepted in 2013-12-22,  发布年份 2014

【 摘 要 】

The public health concerns over the long-term exposure to antibiotics have risen in different parts of the world. The purpose of this study was to investigate the antibiotic consumption pattern in livestock and poultry and to estimate the quantity of antibiotic active ingredient (mg) consumed per unit weight (Kg) of red meat, milk and egg production in Iran in 2010. A cross-sectional study was designed in charmahal - bakhtiary province-Iran. A questioner has been developed by naming 110 types of antibiotics. Twenty two veterinary clinicians and three livestock pharmaceutical distributor companies were included in the survey to determine the antibiotic prescription and distribution pattern in the farms. Veterinary organization of Iran supplied the information of the total antibiotic consumption in different dosage forms. National and international data on the livestock and poultry production were obtained from the relevant official web sites. Tetracycline class of antibiotics was the most common types of antibacterial prescribed and sold to both livestock and poultry farms. Amino glycoside, penicillin and macrolide in the cattle farms and furofenocole in broiler farms were the second most used groups of antibiotics. The quantity of antibiotic active ingredients consumed per unit weight of animal-originated food products was counted as 107.4 mg/kg for both milk and red meat and 249.5 mg/kg for broiler meat and egg. Totally, it was estimated that 133 mg antibiotic substances was used per kg of milk, meat and egg produced in 2010. In comparison to available data for other countries, consumption of antibiotics in livestock and poultry in Iran is higher than developed countries with an exception of South Korea. The findings of the present study could be alarming for the legislative authorities in food security and safety. More clear evaluation should be carried out as well as implementation of national monitoring and inspective programs in order to reach an added safety regarding animal-originated foods.

【 授权许可】

   
2014 Aalipour et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Kümmerer K: Significance of antibiotics in the environment. J Antimicrob Chemother 2003, 52(1):5-7.
• [2]Wise R: Antimicrobial resistance: priorities for action. J Antimicrob Chemother 2002, 49:585-586.
• [3]World Health Organization (WHO): Use of antimicrobials outside human medicine and resultant antimicrobial resistance in humans. Geneva: World Health Organization; 2002.
• [4]Nisha AR: Antibiotic residues - a global health hazard. Vet World 2012, 1:375-377.
• [5]Botsoglou NA, Fletuvris DJ: Drug residue in food: pharmacology, food safety, and analysis. Chapter 3 edition. New York: Basel: Marcel Dekker, Inc; 2001:112.
• [6]Aarestrup FM, Wegener HC, Collignon P: Resistance in bacteria of the food chain: epidemiology and control strategies. Expert Rev Anti Infect Ther 2008, 6(5):733-750.
• [7]Khaskheli M, Malik RS, Arain MA, Soomro AH, Arain HH: Detection of ß-lactam antibiotic residues in market milk. Pak J Nutr 2008, 7(5):682-685.
• [8]Oliveria RP, Jonas AR, Reyes FGR: Streptomycin and dehydrostreptomycin residues in bovine milk from the Brazillian retail market. Food Addit Contam 2010, B(3):156-162.
• [9]Maia PS, Ernani C, Rath S, Reyes FG: Residue content of oxytetracycline applied on tomatoes grown in open field and greenhouse. Food Control 2009, 20:11-16.
• [10]Sahoo KC, Tamhankar AJ, Johansson E, Lundborg CS: Antibiotic use, resistance development and environmental factors: a qualitative study among healthcare professionals in Orissa, India. BMC Public Health 2010, 10:629. BioMed Central Full Text
• [11]Aarestrup FM: Veterinary drug usage and antimicrobial resistance in bacteria of animal origin. Basic Clin Pharmacol Toxicol 2005, 96(4):271-281.
• [12]Kools SAE, Moltmann JF, Knacker T: Estimating the use of veterinary medicines in the European union. Regul Toxicol Pharmacol 2008, 50(1):59-65.
• [13]Movassagh MH: Detection of antibiotics residues in cow raw milk in Bostanabad Region, Iran. Res Opin Anim Vet Sci 2012, 2(1):1-3.
• [14]Movassagh MH: Study of antibiotics residues in Cow Raw milk by Copan milk test in parsabad region, Ardabil province, Iran. Annals Biol Res 2011, 2(4):355-359.
• [15]Tajik H, Malekinejad H, Razavi-Rouhani SM, Pajouhi MR, Mahmoudi R, Haghnazari A: Chloramphenicol residues in chicken liver, kidney and muscle: a comparison among the antibacterial residues monitoring methods of four plate test, ELISA and HPLC. Food Chem Toxicol 2010, 48(8–9):2464-2468.
• [16]Aalipour F, Mirlohi M, Jalali M: Prevalence of contamination with antibiotic residues in commercial milk as affected by the season and different thermal processing. Int J Env Health Eng 2013, 2(1):41.
• [17]Najafzadeh VH: Antibiotics and antimicrobial drugs: (basic concepts and veterinary clinical indications. chapter 4 edition. Iran, Ahvaz: Tarava publication; 2007:51-59.
• [18]Ghamarian AR: Compendium of data sheets for veterinary products. Iran, Tehran: Ghamarian publication; 2008.
• [19]Ministry Agriculture Jahad (MAJ): Food consumption capital. Tehran-Iran: Ministry Agricalture Jahad; 2010. http://dla.agri-jahad.ir/portal/File/ShowFile.aspx?ID=b6197830-8391-42c8-9d61-4c32b911e281 webcite
• [20]Food and Agriculture Organization (FAO): The state food and agriculture in world. Rome: Food and Agriculture Organization; 2009. http://www.fao.org/docrep/012/i0680e/i0680e00.htm webcite
• [21]Moulin G, Cavalie P, Pellanne I, Chevance A, Laval A, Millemann Y, Colin P, Chauvin C: A comparison of antimicrobial usage in human and veterinary medicine in France from 1999 to 2005. J Antimicrob Chemother 2008, 62(3):617-625.
• [22]Beechinor JG: Report on consumption of veterinary antimicrobial drugs in Ireland in 2009. Ir Med J 2011, 104(4):1-3.
• [23]Sarmah AK, Meyer MT, Boxall A: A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere 2006, 65(5):725-759.
• [24]Kim KR, Owens G, Kwon SI, So KH, Lee DB, Ok YS: Occurrence and environmental fate of veterinary antibiotics in the terrestrial environment. Water Air Soil Pollut 2011, 214(1–4):163-174.
• [25]Ungemach FR, Müller-Bahrdt D, Abraham G: Guidelines for prudent use of antimicrobials and their implications on antibiotic usage in veterinary medicine. Int J Med Microbiol 2006, 296:33-38.
• [26]Mohamadi SA, Nikpooyan H, Moshiri R: Aflatoxin M1 contamination and antibiotic residue in milk in Khorasan province, Iran. FoodChem Toxicol 2010, 48(8–9):2130-2132.
• [27]Ehsani EA: Measurement of tetracycline residue in consumed broiler meats in Ahvaz City by HPLC. Research 2010, 2(2):119-130.
• [28]Hosseini M-J, Bakhtiarian A, Khavar RK, Pirali-Hamedani M, Ghazi-Khansari M, Amini M: Monitoring of oxytetracycline in bovine milk by high-performance liquid chromatography with UV-detector. Toxicol Lett 2006, 164(Supplement(0)):S279.
• [29]Aalipour F: Risk Assessment of Tetracycline residues in the marketed pasteurized and sterilized milk in Iran. : Isfahan University of Medical Science, School of Nutrition and Food Science, Departmet of Food Technology; 2013. [MSc thesis]
• [30]Shea KM: Antibiotic resistance: what is the impact of agricultural uses of antibiotics on children’s health. Pediatrics 2003, 112(1):253-258.
• [31]Sung Y, Lee JK, Lee KH, Lee KT, Kang CI: The clinical epidemiology and outcomes of bacteremic biliary tract infections caused by antimicrobial-resistant pathogens. Am J Gastroenterol 2012, 107(3):473-483.
• [32]Taremi M, Mehdi SDM, Gachkar L, MoezArdalan S, Zolfagharian K, Reza ZM: Prevalence and antimicrobial resistance of campylobacter isolated from retail raw chicken and beef meat Tehran, Iran. Int J Food Microbiol 2006, 108(3):401-403.
• [33]Ebrahimi A, Kheirabadi KH, Nikookhah F: Antimicrobial susceptibility of environmental bovine mastitis pathogens in west central Iran. Pak J Biol Sci 2007, 1(10(17)):3014-3016.
• [34]Firoozeh F, Shahcheraghi F, Salehi TZ, Karimi V, Aslani MM: Antimicrobial resistance profile and presence of class I integrongs among salmonella enterica serovars isolated from human clinical specimens in Tehran, Iran. Iran J Microbiol 2011, 3(3):112-117.
• [35]Ghorashi Z, Ghorashi S, Soltani-Ahari H, Nezami N: Demographic features and antibiotic resistance among children hospitalized for urinary tract infection in northwest Iran. Infect Drug Resist 2011, 4:171-176.