Viral infections in prostate carcinomas in Chilean patients

Infectious Agents and Cancer

Francisco Aguayo²  Massimo Tommasino⁶  Iván Gallegos⁴  Jorge Castillo⁵  Omar Espinoza-Navarro³  Tarik Gheit⁶  Oscar León²  Aldo Gaggero²  Mónica L. Acevedo²  Diego Carrillo²  Juan P. Muñoz²  Jorge Levican²  Hector Rodríguez¹ 

[1] Anatomy and Development Biology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago, Chile;Virology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago, Chile;Biology Department, Universidad de Tarapacá, Tarapacá, Chile;Pathological Anatomy Service, Clinical Hospital, Universidad de Chile, Santiago, Chile;Pathological Anatomy Department, Barros Luco-Trudeau Hospital, Universidad de Chile, Santiago, Chile;Infections and Cancer Biology Group, International Agency for Research on Cancer (IARC), Lyon, France

关键词: Virus;    Cancer;    Prostate;   

Others  :  1223377
DOI  :  10.1186/s13027-015-0024-y

 received in 2015-07-02, accepted in 2015-08-17,  发布年份 2015

【 摘 要 】

Background

A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patients.

Methods

Sixty-nine primary prostate carcinomas were analyzed for the presence of HPV, BKPyV and JCPyV using standard polymerase chain reaction protocols. In addition, when samples were positive for HPyV, large T antigen (TAg) transcripts were analyzed using reverse transcriptase PCR.

Results

HPV and JCPyV were not detected in any specimens (0/69, 0 %); whereas, BKPyV was detected in 6/69 PCas (8.7 %). We did not find a statistically significant association between the presence of BKPyV and age (p = 0.198) or Gleason score (p = 0.268). In addition, 2/6 (33 %) BKPyV positive specimens showed detectable levels of TAg transcripts.

Conclusions

There was no association between HPV or JCPyV presence and prostate cancer development. The presence of BKPyV in a small subset of prostate carcinomas in Chilean patients could indicate that this virus plays a potential role in prostate cancer development and requires further investigation.

【 授权许可】

   
2015 Rodríguez et al.

【 图 表 】

Fig. 1.

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