Enhancing myogenic differentiation of pluripotent stem cells with small molecule inducers

Cell & Bioscience

Qiao Li¹  Jihong Chen¹ 

[1] Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada

关键词: Nuclear receptor;    Gene regulation;    Histone acetylation;    Myogenic differentiation;    Stem cells;   

Others  :  791495
DOI  :  10.1186/2045-3701-3-40

 received in 2013-06-12, accepted in 2013-08-16,  发布年份 2013

【 摘 要 】

Pluripotent stem cells are able to differentiate into many types of cell lineages in response to differentiation cues. However, a pure population of lineage-specific cells is desirable for any potential clinical application. Therefore, induction of the pluripotent stem cells with lineage-specific regulatory signals, or small molecule inducers, is a prerequisite for effectively directing lineage specification for cell-based therapeutics. In this article, we provide in-depth analysis of recent research findings on small molecule inducers of the skeletal muscle lineage. We also provide perspectives on how different signaling pathways and chromatin dynamics converge to direct the differentiation of skeletal myocytes.

【 授权许可】

   
2013 Chen and Li; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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