Acute interstitial nephritis with acetaminophen and alcohol intoxication

Italian Journal of Pediatrics

Keith K Lau¹  Iakovina Alexopoulou³  Lauren L Fruchter² 

[1] Department of Pediatrics, McMaster University, Ontario, Canada;Faculty of Health Sciences, McMaster University, Ontario, Canada;Department of Pathology, McMaster University, Ontario, Canada

关键词: alcohol;    acute interstitial nephritis;    renal injury;    acetaminophen;    drug induced hypersensitivity;   

Others  :  829453
DOI  :  10.1186/1824-7288-37-17

 received in 2011-02-08, accepted in 2011-04-15,  发布年份 2011

【 摘 要 】

Drug-induced acute interstitial nephritis (AIN) represents a growing cause of renal failure in current medical practice. While antimicrobials and non-steroidal anti-inflammatory drugs are typically associated with drug-induced AIN, few reports have been made on the involvement of other analgesics. We report our experience in managing a 17-year-old female with AIN and subsequent renal injury following an acetaminophen overdose in conjunction with acute alcohol intoxication. It is well established that acetaminophen metabolism, particularly at high doses, produces reactive metabolites that may induce renal and hepatic toxicity. It is also plausible however, that such reactive species could instead alter renal peptide immunogenicity, thereby inducing AIN. In the following report, we review a possible mechanism for the acetaminophen-induced AIN observed in our patient and also discuss the potential involvement of acute alcohol ingestion in disease onset. The objective of our report is to increase awareness of healthcare professionals to the potential involvement of these commonly used agents in AIN pathogenesis.

【 授权许可】

   
2011 Fruchter et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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