High expression of DDR1 is associated with the poor prognosis in Chinese patients with pancreatic ductal adenocarcinoma

Journal of Experimental & Clinical Cancer Research

Yongwei Sun¹  Rong Hua¹  Junfeng Zhang¹  Jiao Li¹  Dejun Liu¹  Xueliang Fu¹  Jianyu Yang¹  Wei Liu¹  Minwei Yang¹  Yanmiao Huo¹ 

[1] Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai 200127, P.R. China

关键词: Prognosis;    Pancreatic ductal adenocarcinoma;    DDR1;   

Others  :  1226280
DOI  :  10.1186/s13046-015-0202-1

 received in 2015-05-18, accepted in 2015-08-06,  发布年份 2015

【 摘 要 】

Background

Discoidin domain receptors 1 (DDR1), a subtype of DDRs, has been reported as a critical modulator of cellular morphogenesis, differentiation, migration and invasion.

Methods and results

In this study, we investigated the expression of DDR1 and its clinical association in Chinese patients with pancreatic ductal adenocarcinoma (PDAC). Across a cohort of 30 patients, we examined DDR1 expression in paired PDAC and corresponding adjacent non-tumor tissues by real-time quantitative PCR (RT-qPCR), or western blotting. DDR1 expression is significantly higher in PDAC, as compared to normal adjacent tissue, confirming results from the Oncomine databases. We validated DDR1 expression by immunohistochemistry across a non-overlapping cohort of 205 PDAC specimens. Kaplan-Meier survival curves indicate that increased expression of DDR1 is associated with a poor prognosis in PDAC patients (P = 0.013). Multivariate Cox regression analysis identified DDR1 expression, age, N classification and liver metastasis as independent prognostic factors in PDAC.

Conclusions

This study demonstrated that DDR1 can well serve as a novel prognostic biomarker in PDAC.

【 授权许可】

   
2015 Huo et al.

【 图 表 】

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