Inappropriate antidiuretic hormone syndrome presenting as ectopic antidiuretic hormone-secreting gastric adenocarcinoma: a case report

Journal of Medical Case Reports

Dong Jun Park¹  Se-Ho Chang¹  Hyun Seop Cho²  Jong Sil Lee³  Eun Jin Bae²  Ha Nee Jang²  Dae-Hong Jeon²  Kyungo Hwang² 

[1] Institute of Health Science, Gyeongsang National University, College of Medicine, 816 Beongil 15 Jinju-daero, Jinju, South Korea;Department of Internal Medicine, Gyeongsang National University, College of Medicine, 816 Beongil 15 Jinju-daero, Jinju, South Korea;Department of Pathology, Gyeongsang National University, College of Medicine, 816 Beongil 15 Jinju-daero, Jinju, South Korea

关键词: Hyponatremia;    Gastric adenocarcinoma;    ADH;   

Others  :  814379
DOI  :  10.1186/1752-1947-8-185

 received in 2013-10-11, accepted in 2014-03-26,  发布年份 2014

【 摘 要 】

Introduction

Although the syndrome of inappropriate antidiuretic hormone has connection with various malignant tumors, there are few reports associated with advanced gastric cancer.

Case presentation

We describe the case of a 63-year-old Korean male with inappropriate antidiuretic hormone syndrome due to an ectopic antidiuretic hormone-producing advanced gastric adenocarcinoma manifested with overt serum hypo-osmolar hyponatremia and high urinary sodium concentrations. His adrenal, thyroidal, and renal functioning were normal, and the hyponatremia improved following removal of the tumor. The cancer cells were immunostained and found to be positive for the antidiuretic hormone. To our knowledge, this is the first report of an antidiuretic hormone-secreting advanced gastric adenocarcinoma associated with the syndrome of inappropriate antidiuretic hormone, showing cancer cells immunostained for the antidiuretic hormone.

Conclusions

Although a strong relationship between gastric cancer and the syndrome of inappropriate antidiuretic hormone remains to be established, we suggest that gastric cancer could be included as a differential diagnosis of cancer that is associated with the syndrome of antidiuretic hormone.

【 授权许可】

   
2014 Hwang et al.; licensee BioMed Central Ltd.

【 图 表 】

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