Working hard for recovery: mitotic kinases in the DNA damage checkpoint

Cell & Bioscience

Aimin Peng¹ 

[1] Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA

关键词: Gwl;    Aurora;    Plk1;    Cdk;    Mitotic kinases;    Recovery;    DNA damage checkpoint;   

Others  :  791721
DOI  :  10.1186/2045-3701-3-20

 received in 2013-02-04, accepted in 2013-03-28,  发布年份 2013

【 摘 要 】

Cell division in mitosis is tightly regulated via a group of protein kinases. Activation of these mitotic kinases is inhibited by the DNA damage checkpoint that arrests the cell cycle in interphase and prevents mitotic entry. Interestingly, it has been shown that the DNA damage checkpoint is feedback regulated by several mitotic kinases. These kinases are reactivated from checkpoint arrest to deactivate the checkpoint and restart cell cycle progression, thereby allowing the cell to recover from the DNA damage checkpoint. The emerging role of mitotic kinases in the DNA damage pathway provides important insights into cancer progression and treatment.

【 授权许可】

   
2013 Peng; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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